Results 31 to 40 of about 8,887,574 (403)
Activity-by-Contact model of enhancer-promoter regulation from thousands of CRISPR perturbations
Nature Genetics, 2019 Enhancer elements in the human genome control how genes are expressed in specific cell types and harbor thousands of genetic variants that influence risk for common diseases1–4. Yet, we still do not know how enhancers regulate specific genes, and we lack
C. Fulco +18 more
semanticscholar +1 more source
Establishment of regions of genomic activity during the Drosophila maternal to zygotic transition
eLife, 2014 We describe the genome-wide distributions and temporal dynamics of nucleosomes and post-translational histone modifications throughout the maternal-to-zygotic transition in embryos of Drosophila melanogaster.
Xiao-Yong Li +4 more
doaj +1 more source
Frontiers in Immunology, 2022 Immunoglobulin class switch recombination (CSR) plays an important role in humoral imm\une responses by changing the effector functions of antibodies. CSR occurs between highly repetitive switch (S) sequences located upstream of immunoglobulin constant ...
Chloé Oudinet +8 more
doaj +1 more source
eLife, 2017 Sequence variation within enhancers plays a major role in both evolution and disease, yet its functional impact on transcription factor (TF) occupancy and enhancer activity remains poorly understood.
Pierre Khoueiry +6 more
doaj +1 more source
Histone H3K27 acetylation is dispensable for enhancer activity in mouse embryonic stem cells
Genome Biology, 2020 H3K27ac is well recognized as a marker for active enhancers and a great indicator of enhancer activity. However, its functional impact on transcription has not been characterized.
Tiantian Zhang +4 more
semanticscholar +1 more source
WIREs Developmental Biology, 2012 AbstractTranscription of eukaryotic genes is an exceedingly sophisticated and complicated process, orchestrated by layers of control mechanisms involving a myriad of transcription factors and DNA control sequences, with both groups subject to multiple modifications.
openaire +2 more sources
Frontiers in Pediatrics, 2022 Preaxial polydactyly (PPD) is a common congenital abnormality with an incidence of 0.8–1.4% in Asians, characterized by the presence of extra digit(s) on the preaxial side of the hand or foot.
Lei Zeng +11 more
doaj +1 more source
Modulation of enhancer looping and differential gene targeting by Epstein-Barr virus transcription factors directs cellular reprogramming [PDF]
, 2013 Epstein-Barr virus (EBV) epigenetically reprogrammes B-lymphocytes to drive immortalization and facilitate viral persistence. Host-cell transcription is perturbed principally through the actions of EBV EBNA 2, 3A, 3B and 3C, with cellular genes ...
A Calender +117 more
core +3 more sources
Molecular Therapy: Nucleic Acids, 2021 Aberrant expression of long non-coding RNAs (lncRNA) is associated with altered DNA methylation and histone modifications during carcinogenesis. However, identifying epigenetically dysregulated lncRNAs and characterizing their functional mechanisms in ...
Hongying Zhao +12 more
doaj
Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing
Nature Communications, 2020 Tissue-specific gene expression requires coordinated control of gene-proximal and -distal cis-regulatory elements (CREs), yet functional analysis of gene-distal CREs such as enhancers remains challenging.
Kailong Li +10 more
semanticscholar +1 more source