Results 1 to 10 of about 9,920,614 (176)

Identification of cell states using super-enhancer RNA [PDF]

BMC Genomics, 2021
Background A new class of regulatory elements called super-enhancers, comprised of multiple neighboring enhancers, have recently been reported to be the key transcriptional drivers of cellular, developmental, and disease states.
Yueh-Hua Tu, Hsueh-Fen Juan, Hsuan-Cheng Huang   +2 more
doaj   +3 more sources

Bivalent activity of super-enhancer RNA LINC02454 controls 3D chromatin structure and regulates glioma sensitivity to temozolomide [PDF]

Cell Death and Disease
Glioma cell sensitivity to temozolomide (TMZ) is critical for effective treatment and correlates with patient survival, although mechanisms underlying this activity are unclear.
Tengfei Shi, Dianhao Guo, Yaoqiang Zheng, Wenbin Wang, Jinfang Bi, Anshun He, Sibo Fan, Guangsong Su, Xueyuan Zhao, Zhenhao Zhao, Yingjie Song, Shupeng Sun, Peng Li, Zhongfang Zhao, Jiandang Shi, Wange Lu, Lei Zhang   +16 more
doaj   +3 more sources

Enhancer RNA promotes resistance to radiotherapy in bone-metastatic prostate cancer by m⁶A modification. [PDF]

Theranostics, 2023
Rationale: Prostate cancer metastasizes to the bone with the highest frequency and exhibits high resistance to 177Lu-prostate-specific membrane antigen (PSMA) radioligand therapy. Little is known about bone metastatic prostate cancer (mPCa) resistance to
Zhao Y, Wen S, Li H, Pan CW, Wei Y, Huang T, Li Z, Yang Y, Fan S, Zhang Y.   +9 more
europepmc   +2 more sources

Enhancer RNA (eRNA) in Human Diseases. [PDF]

Int J Mol Sci, 2022
Enhancer RNAs (eRNAs), a class of non-coding RNAs (ncRNAs) transcribed from enhancer regions, serve as a type of critical regulatory element in gene expression.
Wang Y, Zhang C, Wang Y, Liu X, Zhang Z.
europepmc   +2 more sources

The enhancer RNA ADCY10P1 is associated with the progression of ovarian cancer. [PDF]

J Ovarian Res, 2022
Background Emerging evidence identifies enhancer RNAs (eRNAs) as a class of regulatory ncRNAs that can contribute to the transcription of target genes. In this study, we used an integrated data analysis method to identify the important role of eRNAs in ...
Mo J, Zhang L, Li H, Duan H, Wang D, Zhao X, Xie Y.   +6 more
europepmc   +2 more sources

Enhancer RNA: What we know and what we can achieve. [PDF]

Cell Prolif, 2022
Enhancers are important cis‐acting elements that can regulate gene transcription and cell fate alongside promoters. In fact, many human cancers and diseases are associated with the malfunction of enhancers.
Han Z, Li W.
europepmc   +2 more sources

A common transcriptional mechanism involving R-loop and RNA abasic site regulates an enhancer RNA of APOE. [PDF]

Nucleic Acids Res, 2022
RNA is modified by hundreds of chemical reactions and folds into innumerable shapes. However, the regulatory role of RNA sequence and structure and how dysregulation leads to diseases remain largely unknown.
Watts JA, Grunseich C, Grunseich C, Rodriguez Y, Liu Y, Li D, Burdick JT, Bruzel A, Crouch RJ, Mahley RW, Wilson SH, Cheung VG.   +11 more
europepmc   +2 more sources

Enhancer transcription profiling reveals an enhancer RNA-driven ferroptosis and new therapeutic opportunities in prostate cancer. [PDF]

Signal Transduct Target Ther
Enhancer RNAs (eRNAs), a subclass of non-coding RNAs transcribed from enhancer regions, have emerged as critical regulators of gene expression; however, their functional roles in prostate cancer remain largely unexplored.
Ma S, Wang Z, Xiong Z, Ge Y, Xu MY, Zhang J, Peng Y, Zhang Q, Sun J, Xi Z, Peng H, Xu W, Wang Y, Li L, Zhang C, Chao Z, Wang B, Gao X, Zhang X, Wei GH, Wang Z.   +20 more
europepmc   +2 more sources

Identification of a SNAI1 enhancer RNA that drives cancer cell plasticity. [PDF]

Nat Commun
Enhancer RNAs (eRNAs) are a pivotal class of enhancer-derived non-coding RNAs that drive gene expression. Here we identify the SNAI1 enhancer RNA (SNAI1e; SCREEM2) as a key activator of SNAI1 expression and a potent enforcer of transforming growth factor-
Fan C, Wang Q, Krijger PHL, Cats D, Selle M, Khorosjutina O, Dhanjal S, Schmierer B, Mei H, de Laat W, Ten Dijke P.   +10 more
europepmc   +2 more sources

Animal-eRNAdb: a comprehensive animal enhancer RNA database. [PDF]

Nucleic Acids Res, 2022
Enhancer RNAs (eRNAs) are a class of non-coding RNAs transcribed from enhancers. As the markers of active enhancers, eRNAs play important roles in gene regulation and are associated with various complex traits and characteristics.
Jin W, Jiang G, Yang Y, Yang J, Yang W, Wang D, Niu X, Zhong R, Zhang Z, Gong J.   +9 more
europepmc   +2 more sources