Results 101 to 110 of about 308,220 (199)

BACH1 recruits STAT3 to enhance leukemia inhibitory factor receptor activity and augments the self-renewal capacity of mouse embryonic stem cells

Stem Cell Research & Therapy
Background Genomic studies have linked single nucleotide variants in the enhancer region of the leukemia inhibitory factor receptor (Lifr) gene to chromatin accessibility and the regulation of self-renewal in mouse embryonic stem cells (mESCs).
Jinghua Ma, Siyu Ma, Cong Niu, Siqing Wang, Xiangxiang Wei, Dan Meng, Xiuling Zhi, Jieyu Guo   +7 more
doaj   +1 more source

Detailed Functional Characterization of a Waist-Hip Ratio Locus in 7p15.2 Defines an Enhancer Controlling Adipocyte Differentiation

iScience, 2019
Summary: We combined CAGE sequencing in human adipocytes during differentiation with data from genome-wide association studies to identify an enhancer in the SNX10 locus on chromosome 7, presumably involved in body fat distribution. Using reporter assays
Casimiro Castillejo-Lopez, Milos Pjanic, Anna Chiara Pirona, Susanne Hetty, Martin Wabitsch, Claes Wadelius, Thomas Quertermous, Erik Arner, Erik Ingelsson   +8 more
doaj   +1 more source

Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands [PDF]

, 1998
Sequence-specific DNA-binding small molecules that can permeate human cells potentially could regulate transcription of specific genes. Multiple cellular DNA-binding transcription factors are required by HIV type 1 for RNA synthesis.
Baird, Eldon E., Dervan, Peter B., Dickinson, Liliane A., Gottesfeld, Joel M., Gulizia, Richard J., Mosier, Donald E., Trauger, John W.   +6 more
core   +1 more source

Enhancing RNA base editing on mammalian transcripts with small nuclear RNAs [PDF]

Nature Chemical Biology
Abstract Endogenous uridine-rich small nuclear RNAs (U snRNAs) form RNA–protein complexes to process eukaryotic pre-mRNA into mRNA. Previous studies have demonstrated programmable U snRNA guide-targeted exon inclusion and exclusion.
Aaron A. Smargon, Deepak Pant, Trent A. Gomberg, Christian Fagre, Sofia Glynne, Johnathan Nguyen, Jack T. Naritomi, Wendy V. Gilbert, Gene W. Yeo   +8 more
openaire   +3 more sources

Bidirectional transcription initiation marks accessible chromatin and is not specific to enhancers

Genome Biology, 2017
Background Enhancers are modular regulatory elements that are central to the spatial and temporal regulation of gene expression. Bidirectional transcription initiating at enhancers has been proposed to mark active enhancers and as such has been utilized ...
Robert S. Young, Yatendra Kumar, Wendy A. Bickmore, Martin S. Taylor   +3 more
doaj   +1 more source

ERNIE-RNA: an RNA language model with structure-enhanced representations

Nature Communications
Existing RNA language models (RLMs) largely overlook structural information in RNA sequences, leading to incomplete feature extraction and suboptimal performance on downstream tasks. In this study, we present ERNIE-RNA (Enhanced Representations with Base-Pairing Restriction for RNA Modeling), an RNA pre-trained language model based on a modified BERT ...
Weijie Yin, Zhaoyu Zhang, Shuo Zhang, Liang He, Ruiyang Zhang, Rui Jiang, Gan Liu, Jingyi Wang, Xuegong Zhang, Tao Qin, Zhen Xie   +10 more
openaire   +2 more sources

High-Resolution Mapping of RNA Polymerases Identifies Mechanisms of Sensitivity and Resistance to BET Inhibitors in t(8;21) AML

Cell Reports, 2016
Bromodomain and extra-terminal domain (BET) family inhibitors offer an approach to treating hematological malignancies. We used precision nuclear run-on transcription sequencing (PRO-seq) to create high-resolution maps of active RNA polymerases across ...
Yue Zhao, Qi Liu, Pankaj Acharya, Kristy R. Stengel, Quanhu Sheng, Xiaofan Zhou, Hojoong Kwak, Melissa A. Fischer, James E. Bradner, Stephen A. Strickland, Sanjay R. Mohan, Michael R. Savona, Bryan J. Venters, Ming-Ming Zhou, John T. Lis, Scott W. Hiebert   +15 more
doaj   +1 more source

Meta-analysis of massively parallel reporter assays enables prediction of regulatory function across cell types. [PDF]

, 2019
Deciphering the potential of noncoding loci to influence gene regulation has been the subject of intense research, with important implications in understanding genetic underpinnings of human diseases.
Ahituv, Nadav, Kreimer, Anat, Yan, Zhongxia, Yosef, Nir   +3 more
core  

The how and why of lncRNA function: An innate immune perspective. [PDF]

, 2020
Next-generation sequencing has provided a more complete picture of the composition of the human transcriptome indicating that much of the "blueprint" is a vastness of poorly understood non-protein-coding transcripts.
Carpenter, Susan, Covarrubias, Sergio, Robinson, Elektra K   +2 more
core  

Histone Deacetylases Positively Regulate Transcription through the Elongation Machinery

Cell Reports, 2015
Transcription elongation regulates the expression of many genes, including oncogenes. Histone deacetylase (HDAC) inhibitors (HDACIs) block elongation, suggesting that HDACs are involved in gene activation.
Celeste B. Greer, Yoshiaki Tanaka, Yoon Jung Kim, Peng Xie, Michael Q. Zhang, In-Hyun Park, Tae Hoon Kim   +6 more
doaj   +1 more source