Results 81 to 90 of about 308,220 (199)
Медицинская иммунологияThe transcription factor STAT3 serves as an immunoregulator by playing a crucial role in cytokine receptor signaling. However, in various cancer cell types, STAT3 is involved in the molecular mechanisms of oncogenesis.
E. M. Stasevich +6 more
doaj +1 more source
JCI Insight, 2021 The G/T transversion rs35705950, located approximately 3 kb upstream of the MUC5B start site, is the cardinal risk factor for idiopathic pulmonary fibrosis (IPF).
Fabienne Gally +16 more
doaj +1 more source
Watching gene expression in color. [PDF]
, 2019 A combination of two fluorescent proteins with different half-lives allows gene expression to be followed with improved time ...
Bates +10 more
core +2 more sources
Epigenomes in Cardiovascular Disease. [PDF]
, 2018 If unifying principles could be revealed for how the same genome encodes different eukaryotic cells and for how genetic variability and environmental input are integrated to impact cardiovascular health, grand challenges in basic cell biology and ...
McKinsey TA +4 more
core +1 more source
Novel cell adhesion/migration pathways are predictive markers of HDAC inhibitor resistance in cutaneous T cell lymphoma [PDF]
, 2019 BACKGROUND: Treatment for Cutaneous T Cell Lymphoma (CTCL) is generally not curative. Therefore, selecting therapy that is effective and tolerable is critical to clinical decision-making. Histone deacetylase inhibitors (HDACi), epigenetic modifier drugs,
Andrews, Jared M +5 more
core +2 more sources
The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation [PDF]
, 2018 The expression of the long noncoding RNA HOTAIR (HOX Transcript Antisense Intergenic RNA) is largely deregulated in epithelial cancers and positively correlates with poor prognosis and progression of hepatocellular carcinoma and gastrointestinal cancers.
A Busanello +51 more
core +1 more source
Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers. [PDF]
, 2017 ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, is frequently mutated in cancer. Deficiency in its homolog ARID1B is synthetically lethal with ARID1A mutation.
Amaral, Maria Luisa +5 more
core +1 more source
Enhancer of RNA polymerase III gene transcription [PDF]
Nucleic Acids Research, 1999 A protein responsible for enhanced transcription by RNA polymerase III was identified in extracts from Xenopus oocytes. This protein, called EP3, interacts with a specific DNA sequence adjacent to the 3'-end of a Xenopus somatic 5S RNA gene and forms a distinct band shift complex with a unique DNase I footprint. Enhanced transcription was observed from
Sturges, Michael R. +2 more
openaire +3 more sources
Characterization of a disease-associated mutation affecting a putative splicing regulatory element in intron 6b of the cystic fibrosis transmembrane conductance regulator (CFTR) gene [PDF]
, 2009 Cystic fibrosis (CF) is a common recessive disorder caused by >1600 mutations in the CF transmembrane conductance regulator (CFTR) gene. About 13% of CFTR mutations are classified as “splicing mutations,” but for almost 40% of these, their role in ...
BAFFICO AM +8 more
core +1 more source
Enhancer-like Properties of an RNA Element That Modulates Tombusvirus RNA Accumulation
Virology, 1999 Prototypical defective interfering (DI) RNAs of the plus-strand RNA virus tomato bushy stunt virus contain four noncontiguous segments (regions I-IV) derived from the viral genome. Region I corresponds to 5'-noncoding sequence, regions II and III are derived from internal positions, and region IV represents a 3'-terminal segment.
Ray, Debashish, White, K.Andrew
openaire +2 more sources