Results 71 to 80 of about 308,220 (199)
Genetic determinants of co-accessible chromatin regions in activated T cells across humans. [PDF]
, 2018 Over 90% of genetic variants associated with complex human traits map to non-coding regions, but little is understood about how they modulate gene regulation in health and disease.
A Barrie +99 more
core +2 more sources
Enhancer RNAs in transcriptional regulation: recent insights
Frontiers in Cell and Developmental Biology, 2023 Enhancers are a class of cis-regulatory elements in the genome that instruct the spatiotemporal transcriptional program. Last decade has witnessed an exploration of non-coding transcripts pervasively transcribed from active enhancers in diverse contexts, referred to as enhancer RNAs (eRNAs).
Qi Chen +6 more
openaire +3 more sources
Stress-induced RNA–chromatin interactions promote endothelial dysfunction
Nature Communications, 2020 Global interaction of chromatin-associated RNAs and DNA can be identified in situ. Here the authors report the genome-wide increase of interchromosomal RNA-DNA interactions and demonstrate the importance of such RNA-DNA contacts exemplified by LINC00607 ...
Riccardo Calandrelli +12 more
doaj +1 more source
Cell Death Discovery, 2023 The transcription factor p63 is a renowned master regulator of gene expression of stratified epithelia. While multiple proteins have been identified as p63 bona fide targets, little is known about non-coding RNAs (ncRNAs) whose transcription is ...
Artem Smirnov +7 more
doaj +1 more source
PLoS ONE, 2021 Emerging evidence has shown that active enhancers are abundantly transcribed, generating long non-coding RNAs, called enhancer RNAs (eRNAs). While putative eRNAs are often observed from RNA sequencing, the roles of most eRNAs remain largely unknown ...
Joshua K Stone +2 more
doaj +1 more source
The pause-initiation limit restricts transcription activation in human cells.
, 2019 Eukaryotic gene transcription is often controlled at the level of RNA polymerase II (Pol II) pausing in the promoter-proximal region. Pausing Pol II limits the frequency of transcription initiation ('pause-initiation limit'), predicting that the pause ...
Cramer, P., Gressel, S., Schwalb, B.
core +1 more source
In vitro evolution of enhanced RNA replicons for immunotherapy [PDF]
Scientific Reports, 2019 AbstractSelf-replicating (replicon) RNA is a promising new platform for gene therapy, but applications are still limited by short persistence of expression in most cell types and low levels of transgene expression in vivo. To address these shortcomings, we developed an in vitro evolution strategy and identified six mutations in nonstructural proteins ...
Yingzhong Li +8 more
openaire +2 more sources
Genomic and epigenomic mapping of leptin-responsive neuronal populations involved in body weight regulation. [PDF]
, 2019 Genome wide association studies (GWAS) in obesity have identified a large number of noncoding loci located near genes expressed in the central nervous system.
Ahituv, Nadav +6 more
core +1 more source
Keratinocyte differentiation-dependent human papillomavirus gene regulation [PDF]
, 2017 Human papillomaviruses (HPVs) cause diseases ranging from benign warts to invasive cancers. HPVs infect epithelial cells and their replication cycle is tightly linked with the differentiation process of the infected keratinocyte.
Graham, Sheila V.
core +1 more source
Properties of a U1 RNA enhancer-like sequence [PDF]
Nucleic Acids Research, 1987 The properties of a X.laevis U1B snRNA gene enhancer have been studied by microinjection in Xenopus oocytes. The enhancer-like sequence, defined as a short DNA stretch that is able to activate transcription in an orientation independent manner, is interchangeable between different U snRNA genes.
G, Ciliberto +4 more
openaire +2 more sources