Results 61 to 70 of about 308,220 (199)

Epigenetic regulation of IFITM1 expression in lipopolysaccharide-stimulated human mesenchymal stromal cells

Stem Cell Research & Therapy, 2020
Background Toll-like receptor 4 (TLR4) ligands such as lipopolysaccharide (LPS) activate immunomodulatory functions and the migration of human mesenchymal stromal cells (hMSCs). Here, we study the migration-related gene expression of LPS-stimulated hMSCs
Sun Hwa Kim, Hae In Choi, Mi Ran Choi, Ga Yeong An, Bert Binas, Kyoung Hwa Jung, Young Gyu Chai   +6 more
doaj   +1 more source

Identification of H3K4me1-associated proteins at mammalian enhancers. [PDF]

, 2017
Enhancers act to regulate cell-type-specific gene expression by facilitating the transcription of target genes. In mammalian cells, active or primed enhancers are commonly marked by monomethylation of histone H3 at lysine 4 (H3K4me1) in a cell-type ...
Albuquerque, Claudio P, Corbett, Kevin D, Ge, Kai, Hsia, Judy E, Huang, Hui, Lee, Ah Young, Local, Andrea, Ren, Bing, Shiau, Andrew K, Singh, Namit, Wang, Chaochen, Wang, Dong, Wang, Wei, Zhou, Huilin   +13 more
core   +2 more sources

Inhibition of aggressive glioblastoma cell line growth by enhancer rna silencing depends on the knockdown method

Медицинская иммунология
Glioblastoma is the most frequent and aggressive brain tumor, with a low survival rate. One of the challenges in treating glioblastoma is the resistance of cells to temozolomide, the main chemical agent used to treat the disease.
E. M. Statsevich, A. V. Simonova, A. V. Poteryakhina, U. R. Beri, E. A. Bogomolova, A. N. Uvarova, M. M. Murashko, E. A. Zheremyan, K. V. Korneev, D. V. Kuprash, D. E. Demin   +10 more
doaj   +1 more source

Genetically regulated eRNA expression predicts chromatin contact frequency and reveals genetic mechanisms at GWAS loci

Nature Communications
The biological functions of extragenic enhancer RNAs and their impact on disease risk remain relatively underexplored. In this work, we develop in silico models of genetically regulated expression of enhancer RNAs across 49 cell and tissue types ...
Michael J. Betti, Phillip Lin, Melinda C. Aldrich, Eric R. Gamazon   +3 more
doaj   +1 more source

Recruitment of Transcription Complexes to Enhancers and the Role of Enhancer Transcription

Biology, 2012
Enhancer elements regulate the tissue- and developmental-stage-specific expression of genes. Recent estimates suggest that there are more than 50,000 enhancers in mammalian cells. At least a subset of enhancers has been shown to recruit RNA polymerase II
Jörg Bungert, Fred Varn, John Strouboulis, Suming Huang, Jared S. Stees   +4 more
doaj   +1 more source

Enhancing Chemotherapy by RNA Interference

BIO Integration, 2020
Abstract Small interfering RNA (siRNA) has shown tremendous potential for treating human diseases in the past decades. siRNA can selectively silence a pathological pathway through the targeting and degradation of a specific mRNA, significantly reducing the off-target side effects of anticancer drugs.
Shuwen Cao, Chunhao Lin, Shunung Liang, Chee Hwee Tan, Phei Er Saw, Xiaoding Xu   +5 more
openaire   +2 more sources

Non-coding Transcripts from Enhancers: New Insights into Enhancer Activity and Gene Expression Regulation

Genomics, Proteomics & Bioinformatics, 2017
Long non-coding RNAs (lncRNAs) have gained widespread interest in the past decade owing to their enormous amount and surprising functions implicated in a variety of biological processes.
Hongjun Chen, Guangshi Du, Xu Song, Ling Li   +3 more
doaj   +1 more source

Splicing of enhancer-associated lincRNAs contributes to enhancer activity

Life Science Alliance, 2020
Analysis of enhancer-associated lincRNA transcripts shows their efficient and conserved splicing contributes to cognate enhancer activity and cis-regulation of target gene expression. Transcription is common at active mammalian enhancers sometimes giving
Jennifer Y Tan, Adriano Biasini, Robert S Young, Ana C Marques   +3 more
doaj   +1 more source

Selective Activation of Alternative MYC Core Promoters by Wnt-Responsive Enhancers. [PDF]

, 2018
In Metazoans, transcription of most genes is driven by the use of multiple alternative promoters. Although the precise regulation of alternative promoters is important for proper gene expression, the mechanisms that mediates their differential ...
Bardales, Jorge A, Darzacq, Xavier, Kawaji, Hideya, Murakawa, Yasuhiro, Wieser, Evin   +4 more
core   +3 more sources

Prediction of Enhancer RNAs in Chicken Genome

International Journal of Molecular Sciences
Enhancer RNAs (eRNAs) play an important role in transcriptional regulation and serve as key intermediates linking genomic enhancers to their target genes. Although ongoing efforts aim to annotate enhancers in the chicken genome, the current understanding of avian enhancers remains less developed compared to that of mammals.
Valentina A. Grushina, Valeria S. Gagarina, Danila E. Prasolov, Fedor A. Kolpakov, Oleg A. Gusev, Sergey S. Pintus   +5 more
openaire   +3 more sources