Evidence for additive and synergistic action of mammalian enhancers during cell fate determination
eLife, 2021 Enhancer activity drives cell differentiation and cell fate determination, but it remains unclear how enhancers cooperate during these processes.
Jinmi Choi +7 more
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Enhancement of RNA self‐cleavage by micellar catalysis [PDF]
FEBS Letters, 1999 It has been reported recently that naturally occurring catalytic RNAs like hammerhead and hairpin ribozyme do not require metal ions for efficient catalysis. It seems that the folded tertiary structure of the RNA contributes more to the catalytic function than was initially recognized.
Riepe, Andrea +2 more
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Affinity-enhanced RNA-binding domains as tools to understand RNA recognition
Cell Reports Methods, 2023 Understanding how the RNA-binding domains of a protein regulator are used to recognize its RNA targets is a key problem in RNA biology, but RNA-binding domains with very low affinity do not perform well in the methods currently available to characterize protein-RNA interactions.
Belén Chaves-Arquero +6 more
openaire +5 more sources
Alteration of Epigenetic Regulation by Long Noncoding RNAs in Cancer [PDF]
, 2018 Long noncoding RNAs (lncRNAs) are important regulators of the epigenetic status of the human genome. Besides their participation to normal physiology, lncRNA expression and function have been already associated to many diseases, including cancer.
Fatica, Alessandro, Morlando, Mariangela
core +2 more sources
The Yin and Yang of enhancer‐like RNAs [PDF]
The EMBO Journal, 2013 Long noncoding RNAs are emerging as a critical component of transcriptional activation. Over the past few years, there has been a number of examples where long noncoding RNAs expressed from distal sites exert their activating functions on neighbouring protein‐coding genes.
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In Vivo Characterization of Linc-p21 Reveals Functional cis-Regulatory DNA Elements
Cell Reports, 2016 The Linc-p21 locus, encoding a long non-coding RNA, plays an important role in p53 signaling, cell-cycle regulation, and tumor suppression. However, despite extensive study, confusion exists regarding its mechanism of action: is activity driven by the ...
Abigail F. Groff +11 more
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A novel element upstream of the Vgamma2 gene in the murine T cell receptor gamma locus cooperates with the 3 enhancer to act as a locus control region. [PDF]
, 1999 Transgenic expression constructs were employed to identify a cis-acting transcription element in the T cell receptor (TCR)-gamma locus, called HsA, between the Vgamma5 and Vgamma2 genes. In constructs lacking the previously defined enhancer (3E(Cgamma1)),
Baker, J +5 more
core
CCAAT/enhancer binding protein β expression is increased in the brain during HIV-1-infection and contributes to regulation of astrocyte tissue inhibitor of metalloproteinase-1 [PDF]
, 2011 Human immunodeficiency virus (HIV)-1-associated neurocognitive disorders (HAND) associated with infection and activation of mononuclear phagocytes (MP) in the brain, occur late in disease. Infected/activated MP initiate neuroinflammation activating glial
Abraham +54 more
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Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells. [PDF]
, 2016 Affinity and dose of T cell receptor (TCR) interaction with antigens govern the magnitude of CD4+ T cell responses, but questions remain regarding the quantitative translation of TCR engagement into downstream signals.
Allison, Karmel A +7 more
core +1 more source
The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity
Cell Reports, 2018 Summary: The RNA polymerase II-associated protein 1 (RPAP1) is conserved across metazoa and required for stem cell differentiation in plants; however, very little is known about its mechanism of action or its role in mammalian cells. Here, we report that
Cian J. Lynch +16 more
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