Results 21 to 30 of about 9,920,783 (328)
Enhancer RNA profiling predicts transcription factor activity [PDF]
Genome Research, 2018 Transcription factors (TFs) exert their regulatory influence through the binding of enhancers, resulting in coordination of gene expression programs. Active enhancers are often characterized by the presence of short, unstable transcripts termed enhancer ...
Joseph Azofeifa +5 more
semanticscholar +3 more sources
Frontiers in Oncology, 2022 Enhancer RNAs (eRNAs) are present specifically in tumors, where they affect the expression of eRNA-regulated genes (ERGs). Owing to this characteristic, ERGs were hypothesized to improve prognosis of overall survival in heterogeneous low-grade and ...
Wei Tian +10 more
doaj +1 more source
Enhancer RNAs step forward: new insights into enhancer function [PDF]
Development, 2022 ABSTRACT Enhancers confer precise spatiotemporal patterns of gene expression in response to developmental and environmental stimuli. Over the last decade, the transcription of enhancer RNAs (eRNAs) – nascent RNAs transcribed from active enhancers – has emerged as a key factor regulating enhancer activity. eRNAs are relatively short-lived
Laura J. Harrison, Daniel Bose
openaire +3 more sources
PLoS ONE, 2023 Non-polyadenylated RNA includes a large subset of crucial regulators of RNA expression and constitutes a substantial portion of the transcriptome, playing essential roles in gene regulation.
Jason D Limberis +3 more
doaj +1 more source
Transcriptional control by enhancers and enhancer RNAs [PDF]
Transcription, 2019 The regulation of gene expression is a fundamental cellular process and its misregulation is a key component of disease. Enhancers are one of the most salient regulatory elements in the genome and help orchestrate proper spatiotemporal gene expression during development, in homeostasis, and in response to signaling.
Michael W. Lewis +2 more
openaire +2 more sources
Functional roles of antisense enhancer RNA for promoting prostate cancer progression
Theranostics, 2021 Rationale: Enhancer RNA (eRNA) bi-directionally expresses from enhancer region and sense eRNA regulates adjacent mRNA in cis and in trans. However, it has remained unclear whether antisense eRNAs in different direction are functional or merely a ...
Chun-Wu Pan +5 more
semanticscholar +1 more source
LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development. [PDF]
, 2020 Developmental progression depends on temporally defined changes in gene expression mediated by transient exposure of lineage intermediates to signals in the progenitor niche.
Benner, Christopher W +14 more
core +2 more sources
Enhancer transcription detected in the nascent transcriptomic landscape of bread wheat
Genome Biology, 2022 The precise spatiotemporal gene expression is orchestrated by enhancers that lack general sequence features and thus are difficult to be computationally identified.
Yilin Xie +6 more
doaj +1 more source
Diversity and Emerging Roles of Enhancer RNA in Regulation of Gene Expression and Cell Fate
Frontiers in Cell and Developmental Biology, 2020 Enhancers are cis-regulatory elements in the genome that cooperate with promoters to control target gene transcription. Unlike promoters, enhancers are not necessarily adjacent to target genes and can exert their functions regardless of enhancer ...
Preston R. Arnold, A. Wells, X. Li
semanticscholar +1 more source