Results 31 to 40 of about 9,920,783 (328)

A Novel Prognostic Tool for Glioma Based on Enhancer RNA-Regulated Immune Genes

Frontiers in Cell and Developmental Biology, 2022
Background: Gliomas are the most malignant tumors of the nervous system. Even though their survival outcome is closely affected by immune-related genes (IRGs) in the tumor microenvironment (TME), the corresponding regulatory mechanism remains poorly ...
Wei Tian, Kegong Chen, Guangcan Yan, Xinhao Han, Yanlong Liu, Qiuju Zhang, Meina Liu   +6 more
doaj   +1 more source

Characterization of transcripts emanating from enhancer Eβ of the murine TCRβ locus

FEBS Open Bio, 2021
Enhancers are well established as critical regulators of gene expression, but the mechanisms underlying the molecular basis of their specificity and activity are only partly understood.
Faizan Uddin, Madhulika Srivastava
doaj   +1 more source

Cell-cycle arrest and senescence in TP53-wild type renal carcinoma by enhancer RNA-P53-bound enhancer regions 2 (p53BER2) in a p53-dependent pathway

Cell Death and Disease, 2020
TP53 is a classic tumor suppressor, but its role in kidney cancer remains unclear. In our study, we tried to explain the role of p53 in kidney cancer through the p53-related enhancer RNA pathway.
Haibiao Xie, K. Ma, Kenan Zhang, Jingcheng Zhou, Lei Li, Wuping Yang, Y. Gong, L. Cai, K. Gong   +8 more
semanticscholar   +1 more source

lncRNA KHPS1 Activates a Poised Enhancer by Triplex-Dependent Recruitment of Epigenomic Regulators

Cell Reports, 2019
Summary: Transcription of the proto-oncogene SPHK1 is regulated by KHPS1, an antisense RNA that activates SPHK1 expression by forming a triple-helical RNA-DNA-DNA structure at the SPHK1 enhancer.
Alena Blank-Giwojna, Anna Postepska-Igielska, Ingrid Grummt   +2 more
doaj   +1 more source

Selective Activation of Alternative MYC Core Promoters by Wnt-Responsive Enhancers. [PDF]

, 2018
In Metazoans, transcription of most genes is driven by the use of multiple alternative promoters. Although the precise regulation of alternative promoters is important for proper gene expression, the mechanisms that mediates their differential ...
Bardales, Jorge A, Darzacq, Xavier, Kawaji, Hideya, Murakawa, Yasuhiro, Wieser, Evin   +4 more
core   +3 more sources

Landscape of Enhancer-Enhancer Cooperative Regulation during Human Cardiac Commitment

Molecular Therapy: Nucleic Acids, 2019
Although accumulating evidence has demonstrated the key roles of enhancers in gene expression regulation, the contribution of genome-wide enhancer-enhancer interactions to developmental decisions remains unclear.
Hong Chen, Jun Xiao, Tingting Shao, Li Wang, Jing Bai, Xiaoyu Lin, Na Ding, Yinwei Qu, Yi Tian, Xiang Chen, Hui Liu, Hongyu Liu, Juan Xu, Xia Li   +13 more
doaj   +1 more source

Neuronal activity-induced BRG1 phosphorylation regulates enhancer activation

Cell Reports, 2021
Summary: Neuronal activity-induced enhancers drive gene activation. We demonstrate that BRG1, the core subunit of SWI/SNF-like BAF ATP-dependent chromatin remodeling complexes, regulates neuronal activity-induced enhancers.
BongWoo Kim, Yi Luo, Xiaoming Zhan, Zilai Zhang, Xuanming Shi, Jiaqing Yi, Zhenyu Xuan, Jiang Wu   +7 more
doaj   +1 more source

The strong enhancer element in the immediate early region of the human cytomegalovirus genome [PDF]

, 1985
The human cytomegalovirus (HCMV), a member of the herpesvirus group, was found to possess a strong transcription enhancer in the immediate early gene region. Co-transfection of enhancerless SV40 DNA with randomly fragmented HCMV DNA yielded two SV40-
Boshart, Michael, Calendar, R., Dorsch-Häsler, Karoline, Fleckenstein, Bernhard, Gold, L., Jahn, Gerhard, Rüger, Rüdiger, Schaffner, Walter, Stoerker, Jay, Weber, Frank   +9 more
core   +1 more source

FOXP4‐AS1 is a favorable prognostic-related enhancer RNA in ovarian cancer

Bioscience Reports, 2021
Ovarian cancer (OV) is the main cause of deaths worldwide in female reproductive system malignancies. Enhancer RNAs (eRNAs) are derived from the transcription of enhancers and has attracted increasing attention in cancers recently.
T. Hua, Yun-jie Tian, Rui-min Wang, Cailian Zhao, Y. Kong, Ruiyang Tian, W. Wang, Li-xia Ma   +7 more
semanticscholar   +1 more source

The bacterial enhancer-dependent RNA polymerase [PDF]

Biochemical Journal, 2016
Transcription initiation is highly regulated in bacterial cells, allowing adaptive gene regulation in response to environment cues. One class of promoter specificity factor called sigma54 enables such adaptive gene expression through its ability to lock the RNA polymerase down into a state unable to melt out promoter DNA for transcription initiation ...
Zhang, N, Darbari, VC, Glyde, R, Zhang, X, Buck, M   +4 more
openaire   +4 more sources