Results 161 to 170 of about 126,781 (219)

Crystal structure of leucine-enkephalin

Nature, 1983
The crystal structure of leucine-enkephalin has been determined in a crystal form that has four independent enkephalin molecules and much water and dimethylformamide solvent in the asymmetric unit. All four enkephalins have extended peptide backbones with the Tyr, Phe and Leu side chains above and below the plane of the backbone. There is evidence that
A, Camerman, D, Mastropaolo, I, Karle, J, Karle, N, Camerman   +4 more
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Monoclonal antibodies to leucine enkephalin

Biochemical and Biophysical Research Communications, 1983
Monoclonal antibodies to leucine enkephalin have been produced after fusion of mouse myeloma cells with spleen cells from hyper-immune mice. Hybrid clones 2D1 and SL1 were characterised using radioimmunoassay and an enzyme-linked immunosorbent assay. The antibody 2D1 was of low affinity and showed a maximum sensitivity of 0.1ng.
C A, Jones, D P, Lane, J, Hughes
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A heterocyclic analog of leucine‐enkephalin

Journal of Heterocyclic Chemistry, 1987
AbstractA series of di‐, tri‐, tetra‐ and pentapeptide analogs of leucine‐enkephalin have been prepared in which the initial tyrosinylglycine fragment has been replaced by the 5,6‐dihydro‐5,5‐dimethyl‐2‐oxo‐3‐phenyl‐1(2H)‐pyrazineacetic acid moiety.
Albert A. Carr, Mark W. Dudley, Edward W. Huber, John M. Kane, Francis P. Miller   +4 more
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Totalsynthese von Leucin‐ und Methonin‐Enkephalin

Justus Liebigs Annalen der Chemie, 1977
AbstractDie in ihren Strukturen aufgeklärten „endogenen Opiate”︁ wurden nach „klassischen Methoden”︁ der Peptidchemie synthetisiert. An das zunächst erhaltene geschützte Tripeptidderivat Boc‐Gly‐Gly‐L‐Phe‐OMe wurden geschütztes Tyrosin und Leucin oder Methionin mit DCC/HOBt gekuppelt.
Emanuel Pietrzik, Hubert Kalbacher, Wolfgang Voelter   +2 more
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The potentiation of spinal analgesia by leucine enkephalin

European Journal of Pharmacology, 1980
In two strains of rats, intrathecal administration of morphine and met-enkephalin was found to produce a dose-dependent analgesic effect as measured by the tail-flick assay. Prior administration of leu-enkelphalin at a dose which had no analgesic effect was found to reduce significantly the analgesic ED50 of both morphine and met-enkephalin.
A A, Larson, J L, Vaught, A E, Takemori
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Hydrolysis of Peripheral Leucine Enkephalin in Allergic Asthma

Clinical Immunology, 1999
Plasma hydrolysis of leucine enkephalin was studied in a group of patients affected by seasonal allergic asthma in acute and quiescent stage; data were compared with those obtained from a control group of healthy volunteers. Results obtained indicate a statistically significant reduction of leu-enkephalin hydrolysis in allergic subjects.
L, Fuso, M, Marini, M, Marzano, B, Nardecchia, L G, Roda, P, Rossi, A, Urbani   +6 more
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Synthesis of leucine enkephalin derivatives: Structure-function studies

Biochemical and Biophysical Research Communications, 1977
Abstract The solid phase synthesis of highly purified [Leu 5 ] enkephalin and of seven derivatives including [Ala 2 ,Leu 5 ]-, [Ser 2 ,Leu 5 ]-, [Ser 3 ,Leu 5 ]-, [Aba 2 ,Leu 5 ]-, and [des-Gly 2(3) ,Leu 5 ]enkephalins are reported, and their morphine-like activities in neuroblastoma x glioma cell homogenates were measured. Changes at the 2, 3, and 5
N S, Agarwal, V J, Hruby, R, Katz, W, Klee, M, Nirenberg   +4 more
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SYNTHESIS OF CHROMOPHORIC DEHYDRO ANALOG OF LEUCINE ENKEPHALIN

International Journal of Peptide and Protein Research, 1981
Dehydropeptides incorporating a highly colored group have been prepared by reacting peptide esters with 4‐(4′‐dimethyl‐amino‐3′‐nitro) benzylidene‐2‐phenyloxazolin‐5‐one. This method allows a rapid synthesis of colored analogs of physiologically important peptides, in this case, leucine enkephalin.
D J, Phelps, J R, Godin
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Leucine-enkephalin metabolism in brain microvessel endothelial cells

Peptides, 1994
The metabolism of leucine-enkephalin was investigated in primary cultures of bovine brain microvessel endothelial cell (BMEC) monolayers. Leucine-enkephalin was hydrolyzed slowly with less than 40% of the peptide metabolized following a 5-h incubation with intact BMEC monolayers at 37 degrees C.
S E, Thompson, K L, Audus
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Trauma Decreases Leucine Enkephalin Hydrolysis in Human Plasma

The Journal of Pharmacology and Experimental Therapeutics, 1999
Plasma hydrolysis of leucine enkephalin was evaluated, together with several cellular immune parameters, in a homogeneous group of human subjects who had undergone severe trauma (proximal femur fracture); data obtained were compared with those obtained in an age-matched control group.
R, Babst, L, Bongiorno, M, Marini, L G, Roda, G, Spagnoli, A, Urbani   +5 more
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