Results 161 to 170 of about 20,144 (188)
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Life Sciences, 1983
Methionine-enkephalin(met-enkephalin)-, leucine-enkephalin(leu-enkephalin)-, methionine-enkephalin-Arg6-Phe7(met-enkephalin-Arg-Phe)- and methionine-enkephalin-Arg6-Gly7-Leu8(met-enkephalin-Arg-Gly-Leu)-like immunoreactivities(-LI) were studied in 16 pheochromocytomas by radioimmunoassays (RIAs) for these four opioid peptides. Met-enkephalin-Arg-Phe-LI
T, Yoshimasa +5 more
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Methionine-enkephalin(met-enkephalin)-, leucine-enkephalin(leu-enkephalin)-, methionine-enkephalin-Arg6-Phe7(met-enkephalin-Arg-Phe)- and methionine-enkephalin-Arg6-Gly7-Leu8(met-enkephalin-Arg-Gly-Leu)-like immunoreactivities(-LI) were studied in 16 pheochromocytomas by radioimmunoassays (RIAs) for these four opioid peptides. Met-enkephalin-Arg-Phe-LI
T, Yoshimasa +5 more
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Secondary ion mass spectra of the neuropeptides leucine-enkephalin and methionine-enkephalin
Biological Mass Spectrometry, 1982Positive and negative secondary ion mass spectra obtained by bombardment of thin films of leucine-enkephalin and methionine-enkephalin with a pulsed beam of Cs+ ions of energy 5–15 keV were recorded using a time-of-flight mass spectrometer. Many of the secondary ions are metastable.
J. B. Westmore, W. Ens, K. G. Standing
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Synthesis and biological activity of chloromethyl ketones of leucine enkephalin
Biochemical and Biophysical Research Communications, 1980Summary The chloromethyl ketones of leucine enkephalin and D-Ala 2 -leucine enkephalin have been synthesized and tested for biological activity in the guinea pig ileum assay. The derivatives show an increased potency in morphine-like action in comparison to the corresponding enkephalins.
J T, Pelton +4 more
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The effects of methionine- and leucine-enkephalin on spinal neurones of the cat
Brain Research, 1979Extra- and intracellular recordings were obtained from physiologically identified, spinal neurones in the 6th and 7th lumbar segments of the pentobarbitone-anaesthetized cat. Microiontophoretically applied methionine- and leucine-enkephalin reversibly inhibited the spontaneous, synaptically induced, and L-glutamate-induced activity in the majority of ...
W, Zieglgänsberger, I F, Tulloch
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Leucine-enkephalin: Reversal of intrinsic cardiovascular stimulation by pentobarbital
European Journal of Pharmacology, 1982In the conscious, chronically instrumented dog, leucine-enkephalin ([Leu5]ENK), 35 micrograms/kg injected intravenously, increased heart rate, respiratory rate, systolic and diastolic systemic arterial pressures, mean pulmonary arterial pressure, and cardiac output. After pentobarbital-induced anesthesia, the same dose of [Leu5]ENK decreased heart rate,
G, Sander +4 more
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Intraventricular self-administration of leucine-enkephalin by laboratory rats
Life Sciences, 1982Naive laboratory rats, without pre-exposure to operant training procedures or to opioids, were shown to self-administer directly into their cerebral ventricles the endogenous opiate peptide, leucine-enkephalin. They were shown to self-administer the peptide consistently for six consecutive days with no indication of the development of tolerance.
B R, Smith, Z W, Brown, Z, Amit
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Nature, 1976
Two new peptides, methionine-enkephalin (met-enkephalin) and leucine–enkephalin (leu-enkephalin), have been isolated from brain, identified and synthesised1. The interest in these compounds lies in their morphine-like activity which was recognised and tested by their action on isolated preparations from the peripheral nervous system.
J P, Gent, J H, Wolstencroft
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Two new peptides, methionine-enkephalin (met-enkephalin) and leucine–enkephalin (leu-enkephalin), have been isolated from brain, identified and synthesised1. The interest in these compounds lies in their morphine-like activity which was recognised and tested by their action on isolated preparations from the peripheral nervous system.
J P, Gent, J H, Wolstencroft
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Brain methionine- and leucine-enkephalin receptors in patients with dementia
Neuroscience Letters, 1993Brain [3H]Met- and [3H]Leu-enkephalin binding was studied in patients with Alzheimer's disease (AD) and vascular dementia (VD), and in age-matched controls. Brain areas investigated were the internal and external globus pallidus, amygdala, hippocampus and temporal cortex.
J O, Rinne +5 more
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Determination of Methionine-Enkephalin and Leucine-Enkephalin in Human Cerebrospinal Fluid
1983Abstract Commercially available radio immunoassay kits were used to find out the concentrations of met-enkephalin and leu-enkephalin in the human concentrated CSF samples in the presence of seven proteinase inhibitors. Reference values were established for lumbar CSF. No correlation was found between total protein content and both enkephalins in CSF.
T.O. KLEINE, B. MERTEN, A. SINGH
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Leucine-enkephalin metabolism in brain microvessel endothelial cells
Peptides, 1994The metabolism of leucine-enkephalin was investigated in primary cultures of bovine brain microvessel endothelial cell (BMEC) monolayers. Leucine-enkephalin was hydrolyzed slowly with less than 40% of the peptide metabolized following a 5-h incubation with intact BMEC monolayers at 37 degrees C.
S E, Thompson, K L, Audus
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