Results 1 to 10 of about 7,124 (165)

Highly sensitive in vivo detection of dynamic changes in enkephalins following acute stress in mice [PDF]

eLife
Enkephalins are opioid peptides that modulate analgesia, reward, and stress. In vivo detection of enkephalins remains difficult due to transient and low endogenous concentrations and inherent sequence similarity.
Marwa O Mikati, Petra Erdmann-Gilmore, Rose Connors, Sineadh M Conway, Jim Malone, Justin Woods, Robert W Sprung, Reid R Townsend, Ream Al-Hasani   +8 more
doaj   +2 more sources

Methionine enkephalin(MENK) upregulated memory T cells in anti-influenza response [PDF]

BMC Immunology, 2023
Novel prophylactic drugs and vaccination strategies for protection against influenza virus should induce specific effector T-cell immune responses in pulmonary airways and peripheral lymphoid organs.
Jing Tian, Wenrui Fu, Zifeng Xie, Xiaonan Wang, Miao Miao, Fengping Shan, Xiaodong Yu   +6 more
doaj   +2 more sources

Methionine enkephalin upregulates the immune function of RAW264.7 cells to inhibit the infection of Nelson Bay orthoreoviruses [PDF]

Scientific Reports
Preliminary research has found that MENK can upregulate the antiviral state of macrophages to inhibit influenza virus infection. To further study the immunomodulatory mechanism of MENK in macrophages against reovirus, we used RNA-Seq technology to ...
Xiaoli Tao, Xiaomeng Wang, Zhuping Ma, Miaojuan Chen, Jing Tian   +4 more
doaj   +2 more sources

Neurotransmitter Imbalance in Tension-Type Headache: A Systematic Review of Mechanisms and Therapeutic Targets [PDF]

Pain and Therapy
Introduction Tension-type headache (TTH) is the most prevalent primary headache disorder worldwide, yet its neurobiological underpinnings remain partially understood.
Lanfranco Pellesi, Aidin Yangjeh, Ibrahim Hajjaj, Mousbah Lababidi, Fezan Sarwar, Wei Wang, Paolo Martelletti   +6 more
doaj   +2 more sources

Exposure to exogenous enkephalins disrupts reproductive development in the Eastern lubber grasshopper, Romalea microptera (Insecta: Orthoptera). [PDF]

PLoS ONE, 2012
Enkephalins play a major role in reproductive physiology in crustaceans; however their role in reproductive development in insects is largely unknown. We investigated the effect of exposure to exogenous leucine-enkephalin (Leu-Enk), methionine-enkephalin
Sandeep Kumar, Ganji Purnachandra Nagaraju, Hojun Song, Laurence von Kalm, David W Borst   +4 more
doaj   +1 more source

Synthesis of New Opioid Analgesic Peptide Analogues to Enkephalin (Leucine- and Methionine-Enkephalin)

Iraqi Journal of Pharmaceutical Sciences, 2017
A small number of researches were done in the design and synthesis of enkephalin analogues that are able to resist degradation effect of proteolytic enzymes with good bioavailability and half-lives.Through studying structure activity relationships we ...
Muthanna S. Al-Ttaee, Kawkab Y. Saour, Ahlam J. Qasir   +2 more
doaj   +3 more sources

THE DISTRIBUTION OF METHIONINE‐ENKEPHALIN AND LEUCINE‐ENKEPHALIN IN THE BRAIN AND PERIPHERAL TISSUES [PDF]

British Journal of Pharmacology, 1977
A method is described for the rapid extraction of opioid peptides from the brain and other tissues. The method is based on acid extraction of tissues followed by adsorption of the extract onto Amberlite XAD‐2 resin. Elution with methanol separates the enkephalins and α‐endorphin from β‐endorphin.Over 90% of the opioid peptide activity isolated from ...
Jeffery Hughes, T.W. Smith, H. W. Kosterlitz   +2 more
openaire   +5 more sources

Proteomics analysis of methionine enkephalin upregulated macrophages against infection by the influenza-A virus

Proteome Science, 2023
Macrophages have a vital role in phagocytosis and antiviral effect against invading influenza viruses. Previously, we found that methionine enkephalin (MENK) inhibited influenza virus infection by upregulating the “antiviral state” of macrophages.
Wenrui Fu, Zifeng Xie, Mei Bai, Zhen Zhang, Yuanlong Zhao, Jing Tian   +5 more
doaj   +1 more source

Computational Approach for Protein Structure Prediction [PDF]

Healthcare Informatics Research, 2013
ObjectivesTo predict the structure of protein, which dictates the function it performs, a newly designed algorithm is developed which blends the concept of self-organization and the genetic algorithm.MethodsAmong many other approaches, genetic algorithm ...
Amouda Venkatesan, Jeyakodi Gopal, Manimozhi Candavelou, Sowjanya Gollapalli, Kayathri Karthikeyan   +4 more
doaj   +1 more source

Functional Characterization and Molecular Marker Development of the Proenkephalin as Biomarker of Food Addiction in Food Habit Domestication of Mandarin Fish (Siniperca chuatsi)

Fishes, 2022
Proenkephalin (PENK), as the precursor of endogenous opioid enkephalin (ENK), is widely present in the nervous system and plays an important role in animal food addiction and rewarding behavior.
Yingcen Li, Yunliang Miao, Xufang Liang, Shan He   +3 more
doaj   +1 more source