Results 21 to 30 of about 9,145 (201)

Actions of D-Ala2-D-Leu5-enkephalin and dynorphin A (1–17) on neocortical neurons in vitro [PDF]

, 1984
Intracellular recordings were made from neocortical neurons in vitro. Application of D-Ala2-D-Leu5-enkephalin (DADL) by different methods produced a decrease in EPSP amplitude and in the amplitude of L-glutamate-induced depolarizations without changes in
B Sutor, Khachaturian, Lewis, Quirion, Satoh, W Zieglgänsberger, Weber, Williams, Williams, Yoshimura, Zieglgänsberger, Zieglgänsberger   +11 more
core   +1 more source

Cerebrospinal fluid levels of opioid peptides in fibromyalgia and chronic low back pain [PDF]

, 2004
Background The mechanism(s) of nociceptive dysfunction and potential roles of opioid neurotransmitters are unresolved in the chronic pain syndromes of fibromyalgia and chronic low back pain.
James N Baraniuk, Gail Whalen, Jill Cunningham, Daniel J Clauw, F Wolfe, F Wolfe, RC Coghill, RH Gracely, LA Bradley, K Fukuda, E Lapossy, T Yoshimasa, A Rosen, M Spetea, JN Baraniuk, JE Ware, S Lyrenaes, H Vaeroy, L Terenius, T Giesecke, MB Yunus, HA Smythe, Z Liu, DX Lui, H Brooks   +24 more
core   +2 more sources

Methionine Enkephalin Suppresses Osteocyte Apoptosis Induced by Compressive Force through Regulation of Nuclear Translocation of NFATc1

JBMR Plus, 2020
Mechanical stress stimulates bone remodeling, which occurs through bone formation and resorption, resulting in bone adaptation in response to the mechanical stress. Osteocytes perceive mechanical stress loaded to bones and promote bone remodeling through
Chisumi Sogi, Nobuo Takeshita, Wei Jiang, Siyoung Kim, Toshihiro Maeda, Michiko Yoshida, Toshihito Oyanagi, Arata Ito, Seiji Kimura, Daisuke Seki, Ikuko Takano, Yuichi Sakai, Ikuma Fujiwara, Shigeo Kure, Teruko Takano‐Yamamoto   +14 more
doaj   +1 more source

Targeted Cell Reprogramming Produces Analgesic Chromaffin-Like Cells from Human Mesenchymal Stem Cells

Cell Transplantation, 2013
Transplantation of allogeneic adrenal chromaffin cells demonstrated the promise of favorable outcomes for pain relief in patients. However, there is a very limited availability of suitable human adrenal gland tissues, genetically well-matched donors in ...
T. Qu M.D., Ph.D., G. Shi, K. Ma, H. N. Yang, W. M. Duan, G. D. Pappas   +5 more
doaj   +1 more source

Biased Metropolis Sampling for Rugged Free Energy Landscapes [PDF]

, 2003
Metropolis simulations of all-atom models of peptides (i.e. small proteins) are considered. Inspired by the funnel picture of Bryngelson and Wolyness, a transformation of the updating probabilities of the dihedral angles is defined, which uses ...
Berg, Bernd A.
core   +3 more sources

Methionine-Enkephalin in Bone and Joint Tissues [PDF]

Journal of Bone and Mineral Research, 1998
Abstract Methionine-enkephalin (met-enk), an endogenous opiate, mimics many of the effects of morphine by binding to opiate receptors, thereby eliciting similar cellular and behavioral effects. Using biochemical and immunohistochemical techniques, several peptides have been identified in bone and joint tissues.
A M, Elhassan, J U, Lindgren, K, Hultenby, J, Bergstrom, A, Adem   +4 more
openaire   +2 more sources

Opioid precursor protein isoform is targeted to the cell nuclei in the human brain [PDF]

, 2017
Background: Neuropeptide precursors are traditionally viewed as proteins giving rise to small neuropeptide molecules. Prodynorphin (PDYN) is the precursor protein to dynorphins, endogenous ligands for the kappa-opioid receptor.
Alkass, Kanar, Andersson, Malin, Bakalkin, Georgy, Bazov, Igor, Druid, Henrik, Dyachok, Oleg, Gerashchenko, Ganna, Kononenko, Olga, Krishtal, Oleg, Mulder, Jan, Rajkowska, Grazyna, Stockmeier, Craig A, Svenningsen, Asa Fex, Verbeek, Dineke S., Watanabe, Hiroyuki, Yakovleva, Tatiana   +15 more
core   +2 more sources

Genetically Engineered Human Mesenchymal Stem Cells Produce Met-Enkephalin at Augmented Higher Levels in Vitro

Cell Transplantation, 2006
We have reported that transplantation of adrenal medullary chromaffin cells that release endogenous opioid peptides into pain modulatory regions in the CNS produce significant antinociceptive effects in patients with terminal cancer pain.
Ikuko Sugaya, Tingyu Qu, Kiminobu Sugaya, George D. Pappas   +3 more
doaj   +1 more source

Hyperpolarization Modulation of the T-Type hCa_v3.2 Channel by Human Synenkephalin [1-53], a Shrew Neurotoxin Analogue without Paralytic Effects. [PDF]

Angew Chem Int Ed Engl
Human synenkephalin [1–53] (hSYN), an analogue peptide of shrew saliva neurotoxins, was synthesized and its structural characteristics studied. Synthetic hSYN potently activated the T‐type voltage‐gated Ca channel hCav3.2 but did not paralyze mealworms. These findings offer new insight into neurological disorder treatment and evolutionary mechanisms of
Fukuoka R, Yano Y, Hara N, Sadamoto C, Maturana AD, Kita M.   +5 more
europepmc   +2 more sources

p-Cresol and p-Cresyl Sulphate Boost Oxidative Stress: A Systematic Review of Recent Evidence. [PDF]

Basic Clin Pharmacol Toxicol
ABSTRACT Recent studies have emphasized the significant role of p‐cresol and its conjugated form, p‐cresyl sulphate (PCS), in enhancing oxidative stress, leading to potential detrimental effects on various biological systems. Both p‐cresol and PCS contribute to increased production of reactive oxygen species (ROS), which can result in tissue damage ...
Renaldi R, Wiguna T, Persico AM, Tanra AJ.   +3 more
europepmc   +2 more sources