Results 161 to 170 of about 9,189 (204)
Some of the next articles are maybe not open access.
The paradoxical role of methionine enkephalin in tumor responses
European Journal of Pharmacology, 2020Methionine enkephalin (MENK) is an opioid peptide composed of five amino acids with multiple biological activities. Since its discovery, MENK has become prominent in neuroregulation and immunoregulation. Tumors have increasingly been a spotlight because of their terrible trends and refractory characteristic.
Yali, Tuo +3 more
openaire +2 more sources
International journal of peptide and protein research, 1980
Biological activities are reported for two different types of analogues of methionine enkephalin. Cyclic analogues, bridged between the amino- and carboxy- terminals of the parent peptide, are inactive. In contrast, significant levels of activity are displayed by linear isosterically modified analogues in which the Tyr1-Gly2 peptide bond is replaced by
D, Hudson, R, Sharpe, M, Szelke
openaire +1 more source
Biological activities are reported for two different types of analogues of methionine enkephalin. Cyclic analogues, bridged between the amino- and carboxy- terminals of the parent peptide, are inactive. In contrast, significant levels of activity are displayed by linear isosterically modified analogues in which the Tyr1-Gly2 peptide bond is replaced by
D, Hudson, R, Sharpe, M, Szelke
openaire +1 more source
Methionine-enkephalin and vasopressin in SHR: effects of dehydration
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1986Enkephalins are found in the posterior pituitary, can alter vasopressin secretion, and have greater pressor effects in spontaneously hypertensive rats (SHR) than in Wistar-Kyoto (WKY) rats. Measurement of the plasma methionine-enkephalin concentration (PMet-Enk) has provided equivocal results in humans and has not been reported in rats.
K, Ota +3 more
openaire +2 more sources
Self-administration of methionine enkephalin into the nucleus accumbens
Pharmacology Biochemistry and Behavior, 1984Microinfusions of the endogenous opiate neurohumor, methionine enkephalin, into the nucleus accumbens initiated a reinforcing stimulus in a dose-related manner. The reinforcing nature of this intracranial self-administration was evaluated with intermittent schedules of reinforcement and a two-lever discrimination procedure.
N E, Goeders, J D, Lane, J E, Smith
openaire +2 more sources
Methionine Enkephalin: Clinical Pharmacology
1986Earlier studies indicated that methionine enkephalin infusions (1,000 micrograms) in normal volunteers induced facial flushing, general vasodilation and noisy stomach (borborgymi). Blood pressure and pulse rate were normal in all experiments. Plasma levels of pancreatic polypeptide, somatostatin, T3 and T4, TSH, FSH, PRL, ACTH, and GH were unchanged ...
N. P. Plotnikoff +8 more
openaire +1 more source
Immunoreactive Methionine-Enkephalin Secretion by Porcine Uterus*
Endocrinology, 1991The current study examined the presence of immunoreactive methionine-enkephalin (ir-MENK) in porcine uterine fluid and endometrial extracts, characterized ir-MENK biochemically, and investigated the effect of ovarian steroids on uterine secretion of ir-MENK. Porcine uterine fluid was collected by flushing the uterine lumen with saline.
W I, Li, L C, Sung, F W, Bazer
openaire +2 more sources
Influence of methionine-enkephalin on stress-induced parameters
International Journal of Immunopharmacology, 1998This study examines the influence of methionine-enkephalin (MENK) on stress-induced oxidative damage (lipid peroxidation; LPO) in mice liver homogenate, plasma corticosterone concentration (CS) and phagocytic activity of mouse splenocytes. The LPO value increased in the mice subjected to restraint stress and had no correlation to stress duration, while
Marotti, Tatjana +4 more
openaire +3 more sources
Methionine enkephalin regulates microglia polarization and function
International Immunopharmacology, 2016Methionine enkephalin (MENK), an opioid peptide, is known to function as a regulator in the immune system. As microglia are considered the most important immune cells in the central nervous system (CNS), we aimed to assess the function of MENK on microglia polarization and tumoricidal responses.
Xuxu, Xu +6 more
openaire +2 more sources
Amino-terminal extension analogs of methionine-enkephalin
Biochemical and Biophysical Research Communications, 1978Abstract Five NH 2 -terminal extension analogs of methionine-enkephalin have been synthesized by solid phase methodology and their morphinomimetic activity determined in the guinea pig ileum-myenteric plexus preparation. Relative to methionine-enkephalin which corresponds to β-LPH-(61–65) and arbitrarily assigned a potency value of 100, β-LPH-(60–65),
N, Ling, S, Minick, R, Guillemin
openaire +2 more sources
Immunocytochemical localization of methionine enkephalin: Preliminary observations
Life Sciences, 1977Abstract Antiserum directed against methionine enkephalin (metenkephalin) was used to determine its anatomical distribution in rat brain. Cross reactivity of that antiserum was not detectable against leucine enkephalin (leu-enkephalin), β-lipotropin (β-LPH), β-endorphin or assorted peptide fragments of met-enkephalin; alpha-endorphin was 370 times ...
S J, Watson +3 more
openaire +2 more sources