Results 11 to 20 of about 109,570 (240)

Computational Approach for Protein Structure Prediction [PDF]

Healthcare Informatics Research, 2013
ObjectivesTo predict the structure of protein, which dictates the function it performs, a newly designed algorithm is developed which blends the concept of self-organization and the genetic algorithm.MethodsAmong many other approaches, genetic algorithm ...
Amouda Venkatesan, Jeyakodi Gopal, Manimozhi Candavelou, Sowjanya Gollapalli, Kayathri Karthikeyan   +4 more
doaj   +1 more source

Functional Characterization and Molecular Marker Development of the Proenkephalin as Biomarker of Food Addiction in Food Habit Domestication of Mandarin Fish (Siniperca chuatsi)

Fishes, 2022
Proenkephalin (PENK), as the precursor of endogenous opioid enkephalin (ENK), is widely present in the nervous system and plays an important role in animal food addiction and rewarding behavior.
Yingcen Li, Yunliang Miao, Xufang Liang, Shan He   +3 more
doaj   +1 more source

Catalytic Serine Labeling in Nonaqueous, Acidic Media. [PDF]

Chemistry
Serine‐targeting protein bioconjugation has been a formidable challenge because of the modest reactivity of the alkyl alcohol group in aqueous media. This work demonstrates a biomolecule‐compatible, nonaqueous approach to achieve alkyl alcohol‐selective labeling through acid‐catalyzed esterification reactions, which offers a unique advantage over the ...
Ishizawa S, Uzoewulu CP, Iwakura Y, Koirala A, Sato S, Ohata J.   +5 more
europepmc   +2 more sources

‘Acetaldehyde‐enkephalins’: elucidation of the structure of the acetaldehyde adducts of methionine‐enkephalin and leucine‐enkephalin [PDF]

FEBS Letters, 1980
The two major endogenous opioid pentapeptides, methionine-enkephalin and leucine-enkephalin [ 1,2] rapidly react with acetaldehyde, under very mild conditions, to give an ‘acetaldehyde-enkephalin’ adduct, referred to as ‘acetaldehyde-enkephalin [Met’] and ‘acetaldehyde-enkephalin [Leu”], respectively 231.
Summers, Michael C., Gidley, Michael J., Sanders, Jeremy K.   +2 more
openaire   +4 more sources

Actions of D-Ala2-D-Leu5-enkephalin and dynorphin A (1–17) on neocortical neurons in vitro [PDF]

, 1984
Intracellular recordings were made from neocortical neurons in vitro. Application of D-Ala2-D-Leu5-enkephalin (DADL) by different methods produced a decrease in EPSP amplitude and in the amplitude of L-glutamate-induced depolarizations without changes in
B Sutor, Khachaturian, Lewis, Quirion, Satoh, W Zieglgänsberger, Weber, Williams, Williams, Yoshimura, Zieglgänsberger, Zieglgänsberger   +11 more
core   +1 more source

Methionine enkephalin: immunomodulator in normal volunteers, cancer and AIDS patients

Memorias do Instituto Oswaldo Cruz, 1987
Clinical studies of the immunological effects of methionine enkephalin in normal volunteers, cancer, and AIDS patients are summarized. The major immunology changes seen were increases in T cell subsets, natural killer activity, as well as mitogen ...
Nicholas P. Plotnikoff, Gerald C. Miller, Nadim F. Nimeh, Joseph Wybran   +3 more
doaj   +1 more source

Label-free metabolic imaging of non-alcoholic-fatty-liver-disease (NAFLD) liver by volumetric dynamic optical coherence tomography [PDF]

Biomed. Opt. Express 13 (2022) 4071-4086, 2022
Label-free metabolic imaging of non-alcoholic fatty liver disease (NAFLD) mouse liver is demonstrated ex vivo by dynamic optical coherence tomography (OCT). The NAFLD mouse is a methionine choline-deficient (MCD)-diet model, and two mice fed MCD diet for 1 and 2 weeks are involved in addition to a normal-diet mouse.
arxiv   +1 more source

Methionine-Enkephalin in Bone and Joint Tissues [PDF]

Journal of Bone and Mineral Research, 1998
Abstract Methionine-enkephalin (met-enk), an endogenous opiate, mimics many of the effects of morphine by binding to opiate receptors, thereby eliciting similar cellular and behavioral effects. Using biochemical and immunohistochemical techniques, several peptides have been identified in bone and joint tissues.
Kjell Hultenby, J. Bergstrom, J. U. Lindgren, Abdu Adem, Adlan M. Elhassan   +4 more
openaire   +3 more sources

Three protected tetrapeptides [PDF]

, 1996
The structures of three protected tetrapeptides, containing the Boc-Gly-Gly-Phe-X-OMe chain, tert-butoxycarbonyl-glycy-glycl-phenylalanine-leucine methyl ester dihydrate, Boc-Gly-Gly-L-Phe-D-Leu-OMe, C25H38N4O7·2H2O, tert-butoxycarbonyl-glycy-glycl ...
Casalone, Gianluigi, Fenude, Emma
core   +1 more source

Voxelwise principal component analysis of dynamic [S-methyl-11C]methionine PET data in glioma patients [PDF]

, 2020
Recent works have demonstrated the added value of dynamic amino acid positron emission tomography (PET) for glioma grading and genotyping, biopsy targeting, and recurrence diagnosis. However, most of these studies are exclusively based on hand-crafted qualitative or semi-quantitative dynamic features extracted from the mean time activity curve (TAC ...
arxiv   +1 more source