Results 11 to 20 of about 5,741 (136)

The role of immune responses and microbiota in adipose tissue homeostasis. [PDF]

J Physiol
Abstract figure legend Gut microbiota regulate white and brown adipose tissue homeostasis via modulation of gut hormone secretion, activation of pathogen‐associated pattern receptors and production of bioactive molecules and metabolites such as short‐chain fatty acids, endocannabinoids, amino acid derivates and bile acids, all of which affect ...
Azar S, Rehermann B.
europepmc   +2 more sources

Hyperpolarization Modulation of the T-Type hCa_v3.2 Channel by Human Synenkephalin [1-53], a Shrew Neurotoxin Analogue without Paralytic Effects. [PDF]

Angew Chem Int Ed Engl
Human synenkephalin [1–53] (hSYN), an analogue peptide of shrew saliva neurotoxins, was synthesized and its structural characteristics studied. Synthetic hSYN potently activated the T‐type voltage‐gated Ca channel hCav3.2 but did not paralyze mealworms. These findings offer new insight into neurological disorder treatment and evolutionary mechanisms of
Fukuoka R, Yano Y, Hara N, Sadamoto C, Maturana AD, Kita M.   +5 more
europepmc   +2 more sources

Chronic Intermittent Ethanol and Withdrawal Suppress Evoked and Spontaneous GABA Release Onto Distinct Populations of Basolateral Amygdala Principal Neurons. [PDF]

Addict Biol
Rat basolateral amygdala principal neurons projecting to the nucleus accumbens (BLANAc) and bed nucleus of the stria terminalis (BLABNST) represent independent cell populations. In male BLANAc neurons only (left), CIE/WD decreases feedforward GABA release from lateral paracapsular interneurons.
Price ME, Egido-Betancourt HX, Sizer SE, Parrish BP, Alexander NJ, Raab-Graham KF, McCool BA.   +6 more
europepmc   +2 more sources

p-Cresol and p-Cresyl Sulphate Boost Oxidative Stress: A Systematic Review of Recent Evidence. [PDF]

Basic Clin Pharmacol Toxicol
ABSTRACT Recent studies have emphasized the significant role of p‐cresol and its conjugated form, p‐cresyl sulphate (PCS), in enhancing oxidative stress, leading to potential detrimental effects on various biological systems. Both p‐cresol and PCS contribute to increased production of reactive oxygen species (ROS), which can result in tissue damage ...
Renaldi R, Wiguna T, Persico AM, Tanra AJ.   +3 more
europepmc   +2 more sources

Computational Approach for Protein Structure Prediction [PDF]

Healthcare Informatics Research, 2013
ObjectivesTo predict the structure of protein, which dictates the function it performs, a newly designed algorithm is developed which blends the concept of self-organization and the genetic algorithm.MethodsAmong many other approaches, genetic algorithm ...
Amouda Venkatesan, Jeyakodi Gopal, Manimozhi Candavelou, Sowjanya Gollapalli, Kayathri Karthikeyan   +4 more
doaj   +1 more source

Human hepatic met-enkephalin and delta opioid receptor-1 immunoreactivities in viral and autoimmune hepatitis

Annals of Hepatology, 2008
Endogenous opioids participate in growth regulation. Liver regeneration relates to growth. Thus, we explored the expression of methionine enkephalin and of the delta opioid receptor 1 immunoreactivities with a polyclonal rabbit antibody in deparaffinized
Vijaya D. Boyella, Anthony D. Nicastri, Nora V. Bergasa   +2 more
doaj   +1 more source

Functional Characterization and Molecular Marker Development of the Proenkephalin as Biomarker of Food Addiction in Food Habit Domestication of Mandarin Fish (Siniperca chuatsi)

Fishes, 2022
Proenkephalin (PENK), as the precursor of endogenous opioid enkephalin (ENK), is widely present in the nervous system and plays an important role in animal food addiction and rewarding behavior.
Yingcen Li, Yunliang Miao, Xufang Liang, Shan He   +3 more
doaj   +1 more source

Methionine enkephalin: immunomodulator in normal volunteers, cancer and AIDS patients

Memorias do Instituto Oswaldo Cruz, 1987
Clinical studies of the immunological effects of methionine enkephalin in normal volunteers, cancer, and AIDS patients are summarized. The major immunology changes seen were increases in T cell subsets, natural killer activity, as well as mitogen ...
Nicholas P. Plotnikoff, Gerald C. Miller, Nadim F. Nimeh, Joseph Wybran   +3 more
doaj   +1 more source

Methionine-Enkephalin in Bone and Joint Tissues [PDF]

Journal of Bone and Mineral Research, 1998
Abstract Methionine-enkephalin (met-enk), an endogenous opiate, mimics many of the effects of morphine by binding to opiate receptors, thereby eliciting similar cellular and behavioral effects. Using biochemical and immunohistochemical techniques, several peptides have been identified in bone and joint tissues.
A M, Elhassan, J U, Lindgren, K, Hultenby, J, Bergstrom, A, Adem   +4 more
openaire   +2 more sources

A close neuroanatomical relationship between the enkephalinergic (methionine-enkephalin) and tachykininergic (substance P) systems in the alpaca diencephalon

Folia Histochemica et Cytobiologica, 2020
INTRODUCTION: In the alpaca diencephalon, the distribution of immunoreactive cell bodies and fibers containing methionine-enkephalin (MET) or substance P (SP) has been studied. MATERIAL AND METHODS: The immunohistochemical study was performed by standard
Pablo Sánchez, Manuel Lisardo Sánchez, Arturo Mangas, Luís Ángel Aguilar, Rafael Coveñas   +4 more
doaj   +1 more source