Results 11 to 20 of about 112,574 (220)

The novel mechanism of anticancer effect on gastric cancer through inducing G0/G1 cell cycle arrest and caspase-dependent apoptosis in vitro and in vivo by methionine enkephalin

Cancer Management and Research, 2018
Xiaonan Wang,1 Jing Tian,1 Xue Jiao,2 Jin Geng,3 Reizhe Wang,4 Ning Liu,5 Xinghua Gao,6 Noreen Griffin,7 Yuan Gao,8 Fengping Shan1 1Department of Immunology, College of Basic Medical Science, China Medical University, Shenyang, China; 2Department of ...
Wang X, Tian J, Jiao X, Geng J, Wang R, Liu N, Gao X, Griffin N, Gao Y, Shan F   +9 more
doaj   +2 more sources

p-Cresol and p-Cresyl Sulphate Boost Oxidative Stress: A Systematic Review of Recent Evidence. [PDF]

Basic Clin Pharmacol Toxicol
ABSTRACT Recent studies have emphasized the significant role of p‐cresol and its conjugated form, p‐cresyl sulphate (PCS), in enhancing oxidative stress, leading to potential detrimental effects on various biological systems. Both p‐cresol and PCS contribute to increased production of reactive oxygen species (ROS), which can result in tissue damage ...
Renaldi R, Wiguna T, Persico AM, Tanra AJ.   +3 more
europepmc   +2 more sources

Hyperpolarization Modulation of the T-Type hCa_v3.2 Channel by Human Synenkephalin [1-53], a Shrew Neurotoxin Analogue without Paralytic Effects. [PDF]

Angew Chem Int Ed Engl
Human synenkephalin [1–53] (hSYN), an analogue peptide of shrew saliva neurotoxins, was synthesized and its structural characteristics studied. Synthetic hSYN potently activated the T‐type voltage‐gated Ca channel hCav3.2 but did not paralyze mealworms. These findings offer new insight into neurological disorder treatment and evolutionary mechanisms of
Fukuoka R, Yano Y, Hara N, Sadamoto C, Maturana AD, Kita M.   +5 more
europepmc   +2 more sources

Human hepatic met-enkephalin and delta opioid receptor-1 immunoreactivities in viral and autoimmune hepatitis

Annals of Hepatology, 2008
Endogenous opioids participate in growth regulation. Liver regeneration relates to growth. Thus, we explored the expression of methionine enkephalin and of the delta opioid receptor 1 immunoreactivities with a polyclonal rabbit antibody in deparaffinized
Vijaya D. Boyella, Anthony D. Nicastri, Nora V. Bergasa   +2 more
doaj   +1 more source

Three protected tetrapeptides [PDF]

, 1996
The structures of three protected tetrapeptides, containing the Boc-Gly-Gly-Phe-X-OMe chain, tert-butoxycarbonyl-glycy-glycl-phenylalanine-leucine methyl ester dihydrate, Boc-Gly-Gly-L-Phe-D-Leu-OMe, C25H38N4O7·2H2O, tert-butoxycarbonyl-glycy-glycl ...
Casalone, Gianluigi, Fenude, Emma
core   +1 more source

‘Acetaldehyde‐enkephalins’: elucidation of the structure of the acetaldehyde adducts of methionine‐enkephalin and leucine‐enkephalin [PDF]

FEBS Letters, 1980
The two major endogenous opioid pentapeptides, methionine-enkephalin and leucine-enkephalin [ 1,2] rapidly react with acetaldehyde, under very mild conditions, to give an ‘acetaldehyde-enkephalin’ adduct, referred to as ‘acetaldehyde-enkephalin [Met’] and ‘acetaldehyde-enkephalin [Leu”], respectively 231.
Summers, Michael C., Gidley, Michael J., Sanders, Jeremy K.   +2 more
openaire   +4 more sources

Methionine enkephalin: immunomodulator in normal volunteers, cancer and AIDS patients

Memorias do Instituto Oswaldo Cruz, 1987
Clinical studies of the immunological effects of methionine enkephalin in normal volunteers, cancer, and AIDS patients are summarized. The major immunology changes seen were increases in T cell subsets, natural killer activity, as well as mitogen ...
Nicholas P. Plotnikoff, Gerald C. Miller, Nadim F. Nimeh, Joseph Wybran   +3 more
doaj   +1 more source

Methionine-enkephalin-treatment suppresses the pituitary-ovary axis in the cichlid fish Oreochromis mossambicus

Aquaculture Reports, 2020
The involvement of endogenous opioid peptides in regulation of reproductive activity is implicated in a majority of vertebrates. Methionine-enkephalin (M-ENK) is an endogenous opioid peptide neurotransmitter produced in the central nervous system ...
C.B. Ganesh, Vijayalaxmi
doaj   +1 more source

Methionine-Enkephalin in Bone and Joint Tissues [PDF]

Journal of Bone and Mineral Research, 1998
Abstract Methionine-enkephalin (met-enk), an endogenous opiate, mimics many of the effects of morphine by binding to opiate receptors, thereby eliciting similar cellular and behavioral effects. Using biochemical and immunohistochemical techniques, several peptides have been identified in bone and joint tissues.
Kjell Hultenby, J. Bergstrom, J. U. Lindgren, Abdu Adem, Adlan M. Elhassan   +4 more
openaire   +3 more sources

New Aspects of Thromboangiitis obliterans (von Winiwarter-Buerger's Disease) [PDF]

, 1984
The existence of thromboangiitis obliterans as a clinical entity has been a matter of debate for many years. In contrast to other immunovasculitides there is no organ involvement while peripheral vessels are affected.
Berlit, Peter, Kessler, C., Krause, Klaus-Henning, Reuther, R.   +3 more
core   +1 more source