Results 61 to 70 of about 9,174 (179)

Hyperpolarization Modulation of the T‐Type hCav3.2 Channel by Human Synenkephalin [1–53], a Shrew Neurotoxin Analogue without Paralytic Effects

Angewandte Chemie, Volume 137, Issue 27, July 1, 2025.
Human synenkephalin [1–53] (hSYN), an analogue peptide of shrew saliva neurotoxins, was synthesized and its structural characteristics studied. Synthetic hSYN potently activated the T‐type voltage‐gated Ca channel hCav3.2 but did not paralyze mealworms. These findings offer new insight into neurological disorder treatment and evolutionary mechanisms of
Ryo Fukuoka, Yusuke Yano, Nozomi Hara, Chihiro Sadamoto, Andres D. Maturana, Masaki Kita   +5 more
wiley   +1 more source

Studies on the small neuropeptide: RPCH and ENK, their function of reproductive regulation in the mud crab, Scylla paramamosain (Estampador, 1949) [PDF]

, 2013
拟穴青蟹（Scyllaparamamosain）是我国东南沿海重要的经济蟹类。本文以拟穴青蟹为研究对象，采用动物生理学、分子生物学、生物信息学等方法和手段，研究了3种小分子神经肽即红色素聚集激素（Redpigmentconcentratinghormone，RPCH）、亮氨酸-脑啡肽（Leucineenkephalin，Leu-ENK）和甲硫氨酸-脑啡肽（Methionineenkephalin，Met-ENK）的结构、特征和生殖调控功能。主要结果如下： （1 ...
曾慧
core  

Adoptive transfer of M2 macrophages reduces neuropathic pain via opioid peptides [PDF]

, 2016
Background During the inflammation which occurs following nerve damage, macrophages are recruited to the site of injury. Phenotypic diversity is a hallmark of the macrophage lineage and includes pro-inflammatory M1 and anti- inflammatory M2 populations ...
Batra, Arvind, Celik, Melih O., Keye, Jacqueline, Labuz, Dominika, Machelska, Halina, Pannell, Maria, Siegmund, Britta   +6 more
core   +2 more sources

Beef hydrolysis by Zyactinase™ enzymes : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy at Massey University, Auckland, New Zealand. [PDF]

, 2016
Protein hydrolysis is the term that applies to all possible ways of splitting proteins to produce products with lower molecular weight. There is a continuous search for novel products derived from waste materials.
Ahmad, Noriza Binti
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The Evolution of Fangs, Venom, and Mimicry Systems in Blenny Fishes [PDF]

, 2017
Venom systems have evolved on multiple occasions across the animal kingdom, and they can act as key adaptations to protect animals from predators. Consequently, venomous animals serve as models for a rich source of mimicry types, as non-venomous ...
Amanda Nouwens, Anthony Romilio, Bryan G. Fry, Gavan M. Cooke, Gregory C. Bird, Han Han, Irina Vetter, Ivan Koludarov, Ivo Que, James Dobson, Jeroen C. Visser, Jordan Debono, Karen L. Cheney, Karine Mardon, Kate Baumann, Louise van der Weerd, Michael K. Richardson, Michael Morgan, Nicholas R. Casewell, Sanjaya Kuruppu, Simon C. Wagstaff, Syed A. Ali, Vera Weisbecker, Wayne C. Hodgson   +23 more
core   +6 more sources

Multi‐Omics Analyses on Maya‐Land Tomatoes Shed Light on Plant Strategies to Thrive in High Temperatures

Physiologia Plantarum, Volume 177, Issue 4, July/August 2025.
ABSTRACT Heat stress limits tomato yield and quality. Deciphering the key genes and metabolites related to heat tolerance is essential for selecting tolerant varieties. In this study, we profiled the transcriptomes and metabolomes of roots and shoots in response to heat stress from a Maya‐land ecotype of heirloom tomato (Calkiní), which grows in ...
Luis F. Maceda‐López, Annie Espinal‐Centeno, Jose Juan Ordaz‐Ortiz, Alfredo Cruz‐Ramírez   +3 more
wiley   +1 more source

A novel non-Opioid binding site for endomorphin-1 [PDF]

, 2016
Endomorphins are natural amidated opioid tetrapeptides with the following structure: Tyr-Pro-Trp-Phe-NH2 (endomorphin-1),and Tyr-Pro-Phe-Phe-NH2 (endomorphin-2).
Benyhe, S., Biyashev, D., Borsodi, A., Lengyel, I., Monory, K., Szatmari, I., Tomboly, C., Toth, F., Toth, G.   +8 more
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Discovery, Herbicidal Activity and Biosynthesis of a Novel Natural Tetramic Acid from Alternaria Species

Advanced Science, Volume 12, Issue 21, June 5, 2025.
The biosynthetic mechanism of novel natural tetramic acid S‐TeA in Alternaria alternata is elucidated. Threonine acts as a precursor for 2‐amino‐3‐methylhexanoic acid (AMHA) synthesis via eight key enzymes from the branched‐chain amino acid biosynthetic pathway in the mitochondrion, wherein three unique enzymes (IPMS, IPMDH, and ISMD) play critical ...
He Wang, Yanjing Guo, Qing Liu, Jing Zhang, Qianlong Zhang, Mingying Yang, Qizhen Chen, Sheng Qiang, Bernal E. Valverde, Shiguo Chen   +9 more
wiley   +1 more source

Rational Design of Single‐Domain Antibodies Targeting the Central Nervous System Neurite Outgrowth Inhibitor Nogo‐A

Applied Research, Volume 4, Issue 3, June 2025.
The development of a nanobody for Nogo‐A, a potent neurite outgrowth inhibitor crucial in multiple sclerosis, is reported using a rational design approach. The nanobody targets the Nogo‐A ectodomain at the S1PR2 receptor‐binding region with submicromolar KD.
Vaidehi Roy Chowdhury, Alexander Röntgen, Matthew Greenig, Yanira Méndez Gómez, Sebastian P. Spiegel, Magdalena Nowinska, Aubin Ramon, Pietro Sormanni, Andrew Chan, Michele Vendruscolo   +9 more
wiley   +1 more source

Evidence of Involvement of the Calcitonin Gene‐Related Peptide in Restless Legs Syndrome

Movement Disorders, Volume 40, Issue 6, Page 1148-1159, June 2025.
Abstract Background Restless legs syndrome (RLS) is a common sensory‐motor disorder characterized by an urge to move the legs, often with unpleasant sensations, particularly during rest. Current treatments include iron supplementation, dopamine agonists, and opioids, but new therapeutic approaches are needed.
Maria P. Mogavero, Mojibola Fowowe, Akeem Sanni, Mona Goli, Giuseppe Lanza, Francesca L'Episcopo, Luigi Ferini‐Strambi, Yehia Mechref, Raffaele Ferri   +8 more
wiley   +1 more source