Results 61 to 70 of about 112,574 (220)

Opioid Receptors in Immune and Glial Cells-Implications for Pain Control [PDF]

, 2020
Opioid receptors comprise μ (MOP), δ (DOP), κ (KOP), and nociceptin/orphanin FQ (NOP) receptors. Opioids are agonists of MOP, DOP, and KOP receptors, whereas nociceptin/orphanin FQ (N/OFQ) is an agonist of NOP receptors.
Celik, Melih Ö., Machelska, Halina
core   +1 more source

Evidence of Involvement of the Calcitonin Gene‐Related Peptide in Restless Legs Syndrome

Movement Disorders, Volume 40, Issue 6, Page 1148-1159, June 2025.
Abstract Background Restless legs syndrome (RLS) is a common sensory‐motor disorder characterized by an urge to move the legs, often with unpleasant sensations, particularly during rest. Current treatments include iron supplementation, dopamine agonists, and opioids, but new therapeutic approaches are needed.
Maria P. Mogavero, Mojibola Fowowe, Akeem Sanni, Mona Goli, Giuseppe Lanza, Francesca L'Episcopo, Luigi Ferini‐Strambi, Yehia Mechref, Raffaele Ferri   +8 more
wiley   +1 more source

N‐ to C‐Peptide Synthesis, Arguably the Future for Sustainable Production

Journal of Peptide Science, Volume 31, Issue 6, June 2025.
The advent of epimerization‐free methods for coupling in N‐ to C‐direction synthesis offers improved atom economy for sustainable peptide synthesis. ABSTRACT A revolution in peptide production arrived from the innovation of carboxylate to amine C‐ to N‐direction solid‐phase synthesis.
Kinshuk Ghosh, William D. Lubell
wiley   +1 more source

Studies on the small neuropeptide: RPCH and ENK, their function of reproductive regulation in the mud crab, Scylla paramamosain (Estampador, 1949) [PDF]

, 2013
拟穴青蟹（Scyllaparamamosain）是我国东南沿海重要的经济蟹类。本文以拟穴青蟹为研究对象，采用动物生理学、分子生物学、生物信息学等方法和手段，研究了3种小分子神经肽即红色素聚集激素（Redpigmentconcentratinghormone，RPCH）、亮氨酸-脑啡肽（Leucineenkephalin，Leu-ENK）和甲硫氨酸-脑啡肽（Methionineenkephalin，Met-ENK）的结构、特征和生殖调控功能。主要结果如下： （1 ...
曾慧
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Proteo‐metabolomic insights for early dual physical and cognitive impairments: A search for biomarkers of healthy aging based on muscle–brain crosstalk

Aging Cell, Volume 24, Issue 3, March 2025.
The study identified dysregulated fatty acid metabolism and inflammation as contributors to physio‐cognitive decline syndrome (PCDS). Sex‐specific metabolic disruptions were noted, with altered central carbon and tyrosine metabolism more pronounced in men and glutathione pathway perturbations more evident in women.
Yi‐Long Huang, Wei‐Ju Chang, Chen‐Hua Huang, Chao‐Hsiung Lin, Li‐Ning Peng, Chih‐Ping Chung, Liang‐Kung Chen, Wei‐Ju Lee   +7 more
wiley   +1 more source

The Evolution of Fangs, Venom, and Mimicry Systems in Blenny Fishes [PDF]

, 2017
Venom systems have evolved on multiple occasions across the animal kingdom, and they can act as key adaptations to protect animals from predators. Consequently, venomous animals serve as models for a rich source of mimicry types, as non-venomous ...
Amanda Nouwens, Anthony Romilio, Bryan G. Fry, Gavan M. Cooke, Gregory C. Bird, Han Han, Irina Vetter, Ivan Koludarov, Ivo Que, James Dobson, Jeroen C. Visser, Jordan Debono, Karen L. Cheney, Karine Mardon, Kate Baumann, Louise van der Weerd, Michael K. Richardson, Michael Morgan, Nicholas R. Casewell, Sanjaya Kuruppu, Simon C. Wagstaff, Syed A. Ali, Vera Weisbecker, Wayne C. Hodgson   +23 more
core   +5 more sources

Catalytic Serine Labeling in Nonaqueous, Acidic Media

Chemistry – A European Journal, Volume 31, Issue 12, February 25, 2025.
Serine‐targeting protein bioconjugation has been a formidable challenge because of the modest reactivity of the alkyl alcohol group in aqueous media. This work demonstrates a biomolecule‐compatible, nonaqueous approach to achieve alkyl alcohol‐selective labeling through acid‐catalyzed esterification reactions, which offers a unique advantage over the ...
Seiya Ishizawa, Chiamaka P. Uzoewulu, Yume Iwakura, Anuja Koirala, Shinichi Sato, Jun Ohata   +5 more
wiley   +1 more source

A novel non-Opioid binding site for endomorphin-1 [PDF]

, 2016
Endomorphins are natural amidated opioid tetrapeptides with the following structure: Tyr-Pro-Trp-Phe-NH2 (endomorphin-1),and Tyr-Pro-Phe-Phe-NH2 (endomorphin-2).
Benyhe, S., Biyashev, D., Borsodi, A., Lengyel, I., Monory, K., Szatmari, I., Tomboly, C., Toth, F., Toth, G.   +8 more
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Adoptive transfer of M2 macrophages reduces neuropathic pain via opioid peptides [PDF]

, 2016
Background During the inflammation which occurs following nerve damage, macrophages are recruited to the site of injury. Phenotypic diversity is a hallmark of the macrophage lineage and includes pro-inflammatory M1 and anti- inflammatory M2 populations ...
Batra, Arvind, Celik, Melih O., Keye, Jacqueline, Labuz, Dominika, Machelska, Halina, Pannell, Maria, Siegmund, Britta   +6 more
core   +2 more sources

Rh‐Catalyzed Hydroamination of Allenes: Asymmetric N‐Allylation of Amino Acids and Peptides

ChemistryEurope, Volume 2, Issue 5, September 9, 2024.
A rhodium‐catalyzed, atom‐economic method for the branched‐selective hydroamination of terminal allenes with α‐amino acid esters is reported. High levels of enantio‐ and diastereoselectivity were achieved by using commercially available ligands, with complete catalyst control demonstrated in several products.
Edward Damer, Bernhard Breit
wiley   +1 more source