Results 171 to 180 of about 46,429 (222)
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Biochemistry of the enkephalins and enkephalin-containing peptides
Archives of Biochemistry and Biophysics, 1983The enkephalins are present in many tissues not only as the free pentapeptides, but also as internal sequences in larger polypeptides of varying size. Fourteen enkephalin-containing peptides (EC peptides) from beef adrenal medulla were isolated and sequenced, and the presence of a protein that contained several [Met]enkephalin sequences and one of [Leu]
Sidney Udenfriend, Daniel L. Kilpatrick
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Enkephalins as immunomodulators
International Journal of Immunopharmacology, 1983The protective effects of methionine enkephalin as well as leucine enkephalin were studied in BDF1 mice inoculated with 1 X 10(4) and 1 X 10(2) cells of L1210 murine leukemia. Significant increases in number of survivors were observed in mice treated with enkephalins.
N. P. Plotnikoff, Gerald C. Miller
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Life Sciences, 1983
Methionine-enkephalin(met-enkephalin)-, leucine-enkephalin(leu-enkephalin)-, methionine-enkephalin-Arg6-Phe7(met-enkephalin-Arg-Phe)- and methionine-enkephalin-Arg6-Gly7-Leu8(met-enkephalin-Arg-Gly-Leu)-like immunoreactivities(-LI) were studied in 16 pheochromocytomas by radioimmunoassays (RIAs) for these four opioid peptides. Met-enkephalin-Arg-Phe-LI
Yoshio Ikeda +5 more
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Methionine-enkephalin(met-enkephalin)-, leucine-enkephalin(leu-enkephalin)-, methionine-enkephalin-Arg6-Phe7(met-enkephalin-Arg-Phe)- and methionine-enkephalin-Arg6-Gly7-Leu8(met-enkephalin-Arg-Gly-Leu)-like immunoreactivities(-LI) were studied in 16 pheochromocytomas by radioimmunoassays (RIAs) for these four opioid peptides. Met-enkephalin-Arg-Phe-LI
Yoshio Ikeda +5 more
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1979
Publisher Summary This chapter discusses the identification and distribution of enkephalins and endorphins. The two main methods of detecting and quantitating enkephalins and endorphins used so far are radioimmunoassay and bioassay. In addition, opioid receptor binding assays were originally utilized to detect general opioid activity.
Richard J. Miller, Pedro Cuatrecasas
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Publisher Summary This chapter discusses the identification and distribution of enkephalins and endorphins. The two main methods of detecting and quantitating enkephalins and endorphins used so far are radioimmunoassay and bioassay. In addition, opioid receptor binding assays were originally utilized to detect general opioid activity.
Richard J. Miller, Pedro Cuatrecasas
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The assay of Met-enkephalin aminopeptidase with [125I]Met-enkephalin
Journal of Biochemical and Biophysical Methods, 1982Presented here are procedural modifications which permit the utilization of 125I-labeled Met-enkephalin as substrate in the assay of rat brain enkephalin aminopeptidase. Th hydrolysis of enkephalin is monitored by the release of [125I]tyrosine separated on Porapak Q.
James L. Caffrey, Donald H. Hodges
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Enkephalin-containing polypeptides are potent inhibitors of enkephalin degradation
Peptides, 1983Enkephalin-containing polypeptides derived from pro-enkephalin A, pro-enkephalin B, or pro-opiomelanocortin were inhibitors of enkephalin degradation by aminoenkephalinases purified from cytosol or membranes. Of the peptides, Argo-Met-enkephalin was the most potent inhibitor for the aminoenkephalinases, with an IC50 of about 0.6 microM, it was more ...
Nicholas Ling +5 more
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Enkephalin Release and Enkephalin-Precursors in Chicken Retina [PDF]
, 1989 The demonstration of enkephalin-like immunoreactive neurons (Brecha, et al., 1979), opiate receptors (Osborne and Hertz, 1981; Slaughter, et al., 1985) and opiate-affected ganglion cell responses (Djamgoz, et al., 1981; Dick and Miller, 1981) favour the acceptance of an opiate-transmitter system in vertebrate retina.
Mark Dowton +2 more
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Enkephalins and nigrostriatal function
Neurology, 1978Unilateral lesions of the substantia nigra were made with 6-hydroxydopamine in rats. In this model, drugs such as naloxone, which block endogenous enkephalin receptors, potentiated agents with postsynaptic dopaminergic actions, while antagonizing agents with presynaptic dopaminergic actions.
Richard L. Borison, Bruce I. Diamond
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International Journal of Peptide and Protein Research, 1983
Two kinds of dehydropeptide analogs of enkephalin containing a ΔTyr unit at the N‐terminus have been synthesized by coupling Boc‐ΔTyr‐(Cl2Bzl)‐OH with amino acid amides and tetrapeptide esters using the water soluble carbodiimide‐HOBt method. Pentapeptides consisting of ΔTyr1, and ΔPhe4 or ΔLeu5 were also prepared.
Aldean J. Kolar +3 more
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Two kinds of dehydropeptide analogs of enkephalin containing a ΔTyr unit at the N‐terminus have been synthesized by coupling Boc‐ΔTyr‐(Cl2Bzl)‐OH with amino acid amides and tetrapeptide esters using the water soluble carbodiimide‐HOBt method. Pentapeptides consisting of ΔTyr1, and ΔPhe4 or ΔLeu5 were also prepared.
Aldean J. Kolar +3 more
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European Journal of Pharmacology, 1980
Morphine is known to produce mydriasis in mice. We have found that enkephalins caused a similar effect. Morphine was twice as active as D-Ala-D-Leu-enkephalin (BW-180C), 5 times as active as Met-enkephalin and 7 times as active as Leu-enkephalin. The time course of the effect was shortest for the enkephalins ( t 1/2 = 8-12 min), intermediate for BW ...
Yechiel Eshel +2 more
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Morphine is known to produce mydriasis in mice. We have found that enkephalins caused a similar effect. Morphine was twice as active as D-Ala-D-Leu-enkephalin (BW-180C), 5 times as active as Met-enkephalin and 7 times as active as Leu-enkephalin. The time course of the effect was shortest for the enkephalins ( t 1/2 = 8-12 min), intermediate for BW ...
Yechiel Eshel +2 more
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