Results 31 to 40 of about 12,769 (228)

Acetaldehyde‐enkephalins: pronounced changes in the opiate activity of methionine‐enkephalin and leucine‐enkephalin on reaction with acetaldehyde [PDF]

FEBS Letters, 1980
We have shown that the two major endogenous opioid peptides, methionine-enkephalin and leucineenkephalin [ 1,2] (enkephalin [Met’] and enkephalin[Leu’]) rapidly react with acetaldehyde in aqueous buffers to give a stable ‘acetaldehyde-enkephalin’ adduct, referred to as ‘acetaldehyde-enkephalin[Met’]’ and ‘acetaldehyde-enkephalin [Leu’]‘, respectively ...
Roger J. Hayes, Michael C. Summers
openaire   +3 more sources

Central administration of human opiorphin alleviates dextran sodium sulfate-induced colitis in mice through activation of the endogenous opioid system

Frontiers in Pharmacology, 2022
The opioid system plays a crucial role in maintaining gastrointestinal homeostasis. Endogenous opioid peptide enkephalins have anti-inflammatory effect and participate in the treatment of inflammatory bowel diseases (IBDs).
Pan Luo, Xuelin Li, Yuan Gao, Zhengjun Chen, Quanwei Zhang, Zhimin Wang, Xiaozhu Tian   +6 more
doaj   +1 more source

Enkephalinase activity is modified and correlates with fatty acids in frontal cortex depending on fish, olive or coconut oil used in the diet

Endocrine Regulations, 2019
Objective. Enkephalins are neuropeptides involved in functions such as pain modulation and/ or cognitive processes. It has been reported that dietary fat modifies enkephalins in the brain.
Segarra Ana B., Prieto Isabel, Martinez-Canamero Magdalena, Ruiz-Sanz Jose-Ignacio, Ruiz-Larrea M. Begona, De Gasparo Marc, Banegas Inmaculada, Zorad Stefan, Ramirez-Sanchez Manuel   +8 more
doaj   +1 more source

Challenges and new opportunities for detecting endogenous opioid peptides in reward

Addiction Neuroscience, 2022
The endogenous opioid peptide system, comprised of enkephalins, endorphins, dynorphins, and nociceptin, is a highly complex neurobiological system. Opioid peptides are derived from four precursor molecules and undergo several processing events yielding ...
Sineadh M. Conway, Marwa O. Mikati, Ream Al-Hasani   +2 more
doaj   +1 more source

A MATERIAL FULL OF PROMISES:Hg1−XCdXTe - MERCURY CADMIUM TELLURID

Journal of Engineering Science (Chişinău), 2023
In recent decades’ doctors and scientists have intensively researched the effect of infrared applications. The rays of infrared devices penetrate the body to a depth of about 5 cm and provide a pleasant warmth, stimulating blood circulation and
BĂJENESCU, Titu-Marius I.
doaj   +1 more source

Involvement of the Opioid Peptide Family in Cancer Progression

Biomedicines, 2023
Peptides mediate cancer progression favoring the mitogenesis, migration, and invasion of tumor cells, promoting metastasis and anti-apoptotic mechanisms, and facilitating angiogenesis/lymphangiogenesis.
Manuel Lisardo Sánchez, Francisco D. Rodríguez, Rafael Coveñas   +2 more
doaj   +1 more source

Downregulation of the endogenous opioid peptides in the dorsal striatum of human alcoholics

Frontiers in Cellular Neuroscience, 2015
The endogenous opioid peptides dynorphins and enkephalins may be involved in brain-area specific synaptic adaptations relevant for different stages of an addiction cycle.
Daniil eSarkisyan, Muhammad Z. Hussain, Hiroyuki eWatanabe, Olga eKononenko, Olga eKononenko, Igor eBazov, Xing Wu eZhou, Olga eYamskova, Oleg eKrishtal, Victor M. Karpyak, Tatiana eYakovleva, Georgy eBakalkin   +11 more
doaj   +1 more source

THE DISTRIBUTION OF METHIONINE‐ENKEPHALIN AND LEUCINE‐ENKEPHALIN IN THE BRAIN AND PERIPHERAL TISSUES [PDF]

British Journal of Pharmacology, 1977
A method is described for the rapid extraction of opioid peptides from the brain and other tissues. The method is based on acid extraction of tissues followed by adsorption of the extract onto Amberlite XAD‐2 resin. Elution with methanol separates the enkephalins and α‐endorphin from β‐endorphin.Over 90% of the opioid peptide activity isolated from ...
Jeffery Hughes, T.W. Smith, H. W. Kosterlitz   +2 more
openaire   +5 more sources

Crosslinking of membrane CD13 in human neutrophils mediates phagocytosis and production of reactive oxygen species, neutrophil extracellular traps and proinflammatory cytokines

Frontiers in Immunology, 2022
Aminopeptidase N, or CD13, is a cell membrane ectopeptidase highly expressed in myeloid cells. Through its enzymatic activity, CD13 regulates the activity of several bioactive peptides, such as endorphins and enkephalins, chemotactic peptides like MCP-1 ...
Erandi Pérez-Figueroa, Pablo Álvarez-Carrasco, Enrique Ortega   +2 more
doaj   +1 more source

From morphine to endogenous opioid peptides, e.g., endorphins: the endless quest for the perfect painkiller

Substantia, 2018
Opium was known since the Neolithic era and in 5th century wild Papaver use was reported to induce sleep and relieving pain. First active component isolated from Opium was morphine, the paradigm of a natural product discovered 150 years before isolation ...
Anna Maria Papini
doaj   +1 more source