Results 31 to 40 of about 12,744 (238)
Substantia, 2018 Opium was known since the Neolithic era and in 5th century wild Papaver use was reported to induce sleep and relieving pain. First active component isolated from Opium was morphine, the paradigm of a natural product discovered 150 years before isolation ...
Anna Maria Papini
doaj +1 more source
Journal of Biological Chemistry, 1983 Enkephalin convertase, an enkephalin-synthesizing carboxypeptidase present in adrenal medulla chromaffin granules, has also been detected in brain and pituitary. To determine whether these three carboxypeptidase activities represent the same enzyme, we purified and characterized enkephalin convertase from adrenal medulla, whole brain, and whole ...
Lloyd D. Fricker, Solomon H. Snyder
openaire +3 more sources
RELEASE OF VASOPRESSIN BY ENKEPHALIN [PDF]
British Journal of Pharmacology, 1978 Leu‐enkephalin, its stable analogue [D‐Ala2‐D‐Leu5]‐enkephalin and the C‐fragment of lipotropin (β endorphin) injected intravenously in the rat produced anti‐diuretic responses which were inhibited reversibly by naloxone. It was shown for Leu‐enkephalin that injection into the cerebral ventricles was at least ten times more effective than intravenous ...
W. Feldberg, G. W. Bisset, H.S. Chowdrey
openaire +3 more sources
The Opioid System in Temporal Lobe Epilepsy: Functional Role and Therapeutic Potential
Frontiers in Molecular Neuroscience, 2017 Temporal lobe epilepsy is considered to be one of the most common and severe forms of focal epilepsies. Patients often develop cognitive deficits and emotional blunting along the progression of the disease.
Johannes Burtscher, Christoph Schwarzer
doaj +1 more source
Geroprotective properties of neuroprotective and neurotrophic peptides
Неврология, нейропсихиатрия, психосоматика, 2020 Objective: to elucidate whether cerebrolysin contains peptide fragments that promote geroprotection.Material and methods. The peptide composition of cerebrolysin underwent a comprehensive mass spectrometric analysis, followed by a systemic biological ...
O. A. Gromova +4 more
doaj +1 more source
μ‐Opioid Receptor Dynamics in the Parameningeal Tissue During Migraine Attacks
Annals of Neurology, EarlyView.Objective The possible impact of meningeal μ‐opioid receptor (μOR) binding in migraine remains unknown. This study investigated μOR availability in the cranial parameninges involved in migraine initiation via nociceptor activation. Methods We used positron emission tomography with [11C] carfentanil, and measured μOR availability in meninges and ...
Dajung J. Kim +6 more
wiley +1 more source
Journal of Biomedical Science, 2010 The present study used the preproenkephalin knockout (ppENK) mice to test whether the endogenous enkephalins deficit could facilitate the anxiety- and depressive-like symptoms of posttraumatic stress disorder (PTSD).
Shyu Bai-Chuang +4 more
doaj +1 more source
Selank effects on morphine-induced analgesia in vivo experiments
Фармакокинетика и Фармакодинамика, 2022 Background. The endogenous opioid system is involved in neuroadaptation produced by exogenous opioids. Synthesized on the basis of the regulatory peptide tuftsin, the anxiolytic selank inhibits the activity of enkephalin-degrading enzymes, increasing the
A. V. Nadorova +2 more
doaj +1 more source
Influence of Mutations of Conserved Arginines on Neuropeptide Binding in the DPP III Active Site
Molecules, 2023 Dipeptidyl peptidase III (DPP III), a zinc exopeptidase, is involved in the final steps of intercellular protein degradation and has a marked affinity for opioid peptides such as enkephalins and endomorphins.
Antonija Tomić +2 more
doaj +1 more source
Deciphering the skeletal interoceptive circuitry to control bone homeostasis
BMEMat, EarlyView.This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu +7 more
wiley +1 more source