Results 41 to 50 of about 33,942 (331)
Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors.
Proceedings of the National Academy of Sciences of the United States of America, 1983 The conformationally restricted, cyclic, disulfide-containing, enkephalin analogs [2-D-penicillamine, 5-L-penicillamine]enkephalin [(D-Pen2,L-Pen5]enkephalin) and [2-D-penicillamine, 5-D-penicillamine]enkephalin [(D-Pen2,D-Pen5]enkephalin) were ...
H. Mosberg +6 more
semanticscholar +1 more source
RB101-mediated Protection of Endogenous Opioids: Potential Therapeutic Utility? [PDF]
, 2007 The endogenous opioids met- and leu-enkephalin are inactivated by peptidases preventing the activation of opioid receptors. Inhibition of enkephalin-degrading enzymes increases endogenous enkephalin levels and stimulates robust behavioral effects. RB101,
Jutkiewicz, Emily M.
core +1 more source
Downregulation of the endogenous opioid peptides in the dorsal striatum of human alcoholics
Frontiers in Cellular Neuroscience, 2015 The endogenous opioid peptides dynorphins and enkephalins may be involved in brain-area specific synaptic adaptations relevant for different stages of an addiction cycle.
Daniil eSarkisyan +11 more
doaj +1 more source
Racecadotril for acute diarrhoea in children: systematic review and meta-analyses [PDF]
, 2015 OBJECTIVE Racecadotril is an antisecretory agent that can prevent fluid/electrolyte depletion from the bowel as a result of acute diarrhoea, without affecting intestinal motility. An up-to-date systematic review is indicated to summarise the evidence on
Alam +31 more
core +1 more source
THE DISTRIBUTION OF METHIONINE‐ENKEPHALIN AND LEUCINE‐ENKEPHALIN IN THE BRAIN AND PERIPHERAL TISSUES [PDF]
British Journal of Pharmacology, 1977 A method is described for the rapid extraction of opioid peptides from the brain and other tissues. The method is based on acid extraction of tissues followed by adsorption of the extract onto Amberlite XAD‐2 resin. Elution with methanol separates the enkephalins and α‐endorphin from β‐endorphin.
Jeffery Hughes +2 more
openaire +5 more sources
Frontiers in Immunology, 2022 Aminopeptidase N, or CD13, is a cell membrane ectopeptidase highly expressed in myeloid cells. Through its enzymatic activity, CD13 regulates the activity of several bioactive peptides, such as endorphins and enkephalins, chemotactic peptides like MCP-1 ...
Erandi Pérez-Figueroa +2 more
doaj +1 more source
Neuropharmacological targets for drug action in vestibular sensory pathways [PDF]
, 2017 The use of pharmacological agents is often the preferred approach to the management of vestibular dysfunction. In the vestibular sensory pathways, the sensory neuroepithelia are thought to be influenced by a diverse number of neuroactive substances that ...
Jones, Timothy A, Lee, Choongheon
core +3 more sources
Metropolis Importance Sampling for Rugged Dynamical Variables [PDF]
Phys. Rev. Lett. 90, 180601 (2003), 2002 A funnel transformation is introduced, which acts recursively from higher towards lower temperatures. It biases the a-priori probabilities of a canonical or generalized ensemble Metropolis simulation, so that they zoom in on the global energy minimum, if a funnel exists indeed.
arxiv +1 more source
Neuropeptides and excitability of mammalian spinal neurons [PDF]
, 1981 The neuroactive peptides, substance P (SP), methionine-enkephalin (ME), somatostatin (SS) and neurotensin (NT), have been implicated recently in synaptic transmission processes at the level of spinal cord areas intimately involved in sensory integration.
Miletić, Vjekoslav
core +3 more sources
Biochemical Journal, 1984 Endopeptidase-24.11 (EC 3.4.24.11), purified to homogeneity from pig kidney, was shown to hydrolyse a wide range of neuropeptides, including enkephalins, tachykinins, bradykinin, neurotensin, luliberin and cholecystokinin.
R. Matsas, A. Kenny, A. Turner
semanticscholar +1 more source