Results 61 to 70 of about 12,769 (228)

Simultaneous mass spectrometry imaging of multiple neuropeptides in the brain and alterations induced by experimental parkinsonism and L-DOPA therapy

Neurobiology of Disease, 2020
Neuropeptides are important signalling molecules in the brain and alterations in their expression levels have been linked to neurological disorders such as Parkinson's disease. It is challenging to map neuropeptide changes across and within brain regions
Heather Hulme, Elva Fridjonsdottir, Halla Gunnarsdottir, Theodosia Vallianatou, Xiaoqun Zhang, Henrik Wadensten, Reza Shariatgorji, Anna Nilsson, Erwan Bezard, Per Svenningsson, Per E. Andrén   +10 more
doaj   +1 more source

Electroacupuncture as a treatment for suspected trigeminal nerve‐mediated head‐shaking in 42 horses

Equine Veterinary Education, EarlyView.
Summary Background Electroacupuncture (EA) has been used successfully as a treatment for trigeminal nerve‐mediated head‐shaking (TMHS) in a small case series, but results from a larger number of cases are lacking. Objectives To retrospectively investigate the effectiveness of EA as a treatment for horses with TMHS.
B. Dunkel, G. L. Hildon, K. M. Coumbe, E. Busuttil, D. von Schweinitz, S. Devereux   +5 more
wiley   +1 more source

Endogenous opioid systems alterations in pain and opioid use disorder

Frontiers in Systems Neuroscience, 2022
Decades of research advances have established a central role for endogenous opioid systems in regulating reward processing, mood, motivation, learning and memory, gastrointestinal function, and pain relief.
Jessica A. Higginbotham, Jessica A. Higginbotham, Jessica A. Higginbotham, Tamara Markovic, Nicolas Massaly, Nicolas Massaly, Nicolas Massaly, Jose A. Morón, Jose A. Morón, Jose A. Morón, Jose A. Morón, Jose A. Morón   +11 more
doaj   +1 more source

The distribution and functions of the enkephalins. [PDF]

Journal of Histochemistry & Cytochemistry, 1980
The enkephalins are two pentapeptides with pharmacological properties similar to narcotic drugs. These peptides are widely distributed in the central nervous system. The basal ganglia contain particularly high concentrations of enkaphalins. In the caudate nucleus ultrastructural studies show that enkephalin is contained within synaptic vesicles ...
Richard J. Miller, Virginia M. Pickel
openaire   +2 more sources

Molecular basis of domain‐specific angiotensin I‐converting enzyme inhibition by the antihypertensive drugs enalaprilat, ramiprilat, trandolaprilat, quinaprilat and perindoprilat

The FEBS Journal, EarlyView.
Inhibition of angiotensin I‐converting enzyme is an effective strategy for the treatment of hypertension. However, the clinically available ACE inhibitors cause side effects due to nonselective inhibition of the two catalytic domains of ACE (nACE and cACE).
Kyle S. Gregory, Vinasha Ramasamy, Edward D. Sturrock, K. Ravi Acharya   +3 more
wiley   +1 more source

Electroacupuncture attenuates retinal ischemia/reperfusion injury by protecting the outer blood-retina barrier via enkephalins activate delta opioid receptor

World Journal of Acupuncture - Moxibustion
Objectives: Retinal ischemia-reperfusion (RIR) injury results in irreversible visual impairments. The disruption of the outer blood-retinal barrier (OBRB) is a major ocular pathogenic process that RIR injury affects.
Ping CHEN, Xian-dan ZHU, Run-jie GUO, Yong XIA, Jing-ling JIN, Nan-ge JIN, Ying-min GU, Xue-song TIAN   +7 more
doaj   +1 more source

Clinical significance of exercise‐induced hypoalgesia in individuals with temporomandibular disorders and neck pain: A clinical trial protocol

Experimental Physiology, EarlyView.
Abstract Evidence reports positive effects of neck motor control and aerobic exercises (AEs) to improve pain in individuals with temporomandibular disorders (TMD) and neck pain. A single bout of exercise typically leads to an increase in pain thresholds up to 30 min post‐exercise, known as exercise‐induced hypoalgesia (EIH).
Luiz Felipe Tavares, Ana Izabela Sobral de Oliveira‐Souza, Vladimir Aron, Ana Beatriz Oliveira, Henrik Bjarke Vaegter, Susan Armijo‐Olivo   +5 more
wiley   +1 more source

Asthma induced by enkephalin. [PDF]

BMJ, 1980
A total of 291 diabetics were studied to see whether an asthmatic reaction was associated with facial flushing induced by chlorpropamide and alcohol. Of these patients, 191 reported facial flushing, of whom 12 reported breathlessness as well. Of these 12, five also described wheezing, and respiratory function tests showed them to have asthma.
David Pyke, Richard David Leslie, D Bellamy   +2 more
openaire   +3 more sources

The effectiveness of aerobic exercise on pain and disability in individuals with neck pain: A systematic review and meta‐analysis

Experimental Physiology, EarlyView.
Abstract The present review aimed to investigate the effectiveness of aerobic exercise (AE) compared to other interventions in decreasing pain intensity and reducing disability in individuals with neck pain. A systematic review (SR) of randomized controlled trials was conducted. This SR was registered in PROSPERO (CRD42021231231).
Ana lzabela Sobral de Oliveira‐Souza, Marie Kempe, Sofia Grimmelsmann, Luiz Felipe Tavares, Ester Moreira De Castro‐Carletti, Angela Viegas Andrade, Liz Dennett, Harry Von Piekartz, Jorge Fuentes Contreras, Susan Armijo‐Olivo   +9 more
wiley   +1 more source

Stable Nitrogen Isotope Analysis of Amino Acids by Orbitrap Mass Spectrometry: Application for Extraterrestrial Samples

Rapid Communications in Mass Spectrometry, Volume 39, Issue 23, 15 December 2025.
ABSTRACT Background Obtaining isotopic data on soluble organic compounds, such as amino acids, in extraterrestrial samples is crucial for understanding their origins, prebiotic chemistry, and potential contamination. Conventional GC‐IRMS requires grams of material to measure isotopic compositions, limiting the analysis of low‐concentration organics in ...
O. M. McIntosh, A. A. Baczynski, M. Matney, H. L. McLain, K. K. Farnsworth, J. P. Dworkin, D. P. Glavin, J. E. Elsila, H. Xie, K. H. Freeman   +9 more
wiley   +1 more source