Results 61 to 70 of about 18,114 (279)

Simultaneous mass spectrometry imaging of multiple neuropeptides in the brain and alterations induced by experimental parkinsonism and L-DOPA therapy

open access: yesNeurobiology of Disease, 2020
Neuropeptides are important signalling molecules in the brain and alterations in their expression levels have been linked to neurological disorders such as Parkinson's disease. It is challenging to map neuropeptide changes across and within brain regions
Heather Hulme   +10 more
doaj   +1 more source

Expression of the Antimicrobial Peptide Piscidin 1 and Neuropeptides in Fish Gill and Skin: A Potential Participation in Neuro-Immune Interaction

open access: yesMarine Drugs, 2022
Antimicrobial peptides (AMPs) are found widespread in nature and possess antimicrobial and immunomodulatory activities. Due to their multifunctional properties, these peptides are a focus of growing body of interest and have been characterized in several
Giacomo Zaccone   +15 more
doaj   +1 more source

Recent Advancements in the Characterization of D‐Amino Acid and Isoaspartate Post‐Translational Modifications

open access: yesMass Spectrometry Reviews, EarlyView.
ABSTRACT One of the great triumphs of mass spectrometry‐based peptide and protein characterization is the characterization of their modifications as most modifications have a characteristic mass shift. What happens when the modification does not change the mass of the peptide?
Samuel Okyem, Jonathan V. Sweedler
wiley   +1 more source

Peptide ligand recognition by G protein-coupled receptors [PDF]

open access: yes, 2015
Introduction: This study was conducted to investigate the effects of thyme extract in drinking water on immune response of broiler chickens. Methods: A total of 245-day-old broiler chicks were purchased and 20 chicks were bled for determination maternal ...
Brian E. Krumm, Reinhard Grisshammer
core   +4 more sources

Thermometer Ions, Internal Energies, and In‐Source Fragmentation in Ambient Ionization

open access: yesMass Spectrometry Reviews, EarlyView.
ABSTRACT Ionization and fragmentation are at the core of mass spectrometry. But they are not necessarily separated in space, as in‐source fragmentation can also occur. Here, we survey the literature published since our 2005 review on the internal energy and fragmentation in electrospray ionization sources.
Emilie Bertrand, Valérie Gabelica
wiley   +1 more source

Endogenous opioid systems alterations in pain and opioid use disorder

open access: yesFrontiers in Systems Neuroscience, 2022
Decades of research advances have established a central role for endogenous opioid systems in regulating reward processing, mood, motivation, learning and memory, gastrointestinal function, and pain relief.
Jessica A. Higginbotham   +11 more
doaj   +1 more source

Growth Hormone (GH)-Releasing Peptide Stimulation of GH Release from Human Somatotroph Adenoma Cells: Interaction with GH-Releasing Hormone, Thyrotropin- Releasing Hormone, and Octreotide. [PDF]

open access: yes, 1994
The synthetic hexapeptide GH-releasing peptide (GHRP; His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) specifically stimulates GH secretion in humans in vivo and in animals in vitro and in vivo via a still unknown receptor and mechanism.
Brockmeier, S.   +7 more
core   +1 more source

Cerebrospinal Fluid Proenkephalin Predicts Striatal Atrophy Decades before Clinical Motor Diagnosis in Huntington's Disease

open access: yesMovement Disorders, EarlyView.
Abstract Background Huntington's disease (HD) is characterized by early, selective, progressive vulnerability of striatal medium spiny neurons (MSNs). Proenkephalin (PENK), a precursor of opioid peptides abundantly expressed in MSNs, is a promising biomarker of striatal integrity, but region‐specific associations and its potential for early‐stage ...
Mena Farag   +14 more
wiley   +1 more source

Electroacupuncture attenuates retinal ischemia/reperfusion injury by protecting the outer blood-retina barrier via enkephalins activate delta opioid receptor

open access: yesWorld Journal of Acupuncture - Moxibustion
Objectives: Retinal ischemia-reperfusion (RIR) injury results in irreversible visual impairments. The disruption of the outer blood-retinal barrier (OBRB) is a major ocular pathogenic process that RIR injury affects.
Ping CHEN   +7 more
doaj   +1 more source

Psychoneuroimmunology-Based Stress Management during Adjuvant Chemotherapy for Early Breast Cancer [PDF]

open access: yes, 2013
Objective. In a randomized trial of women with early stage breast cancer undergoing adjuvant chemotherapy, two stress management interventions, tai chi training and spiritual growth groups, were compared to a usual care control group, to evaluate ...
Elswick, R. K., Jr.   +5 more
core   +2 more sources

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