Results 61 to 70 of about 18,028 (272)

A drug delivery strategy: binding enkephalin to asialoglycoprotein receptor by enzymatic galactosylation. [PDF]

PLoS ONE, 2014
Glycosylation of biopharmaceuticals can mediate cell specific delivery by targeting carbohydrate receptors. Additionally, glycosylation can improve the physico-chemical (drug-like) properties of peptide based drug candidates.
Michelle P Christie, Pavla Simerská, Freda E-C Jen, Waleed M Hussein, Mohamad F M Rawi, Lauren E Hartley-Tassell, Christopher J Day, Michael P Jennings, Istvan Toth   +8 more
doaj   +1 more source

Molecular imprinting for neurology: Materials, applications, and limitations

Ibrain, EarlyView.
Molecularly imprinted materials: diagnostic, therapeutic and research applications in neurology. Molecularly imprinted materials offer high specificity and affinity for target molecules in neurological applications. This review highlights their synthesis, characterisation, and use in diagnostics, research and therapeutics.
Xiaohan Ma, Yingqi Ma, Claudia Marino, Alessandro Poma   +3 more
wiley   +1 more source

Whole‐brain cell‐cell interaction patterns explain tissue damage in several neurodegenerative conditions

Alzheimer's &Dementia, Volume 21, Issue S1, December 2025.
Abstract Background Disrupted interactions among neurons, glial and vascular cell types can lead to inflammation, vascular dysfunction, and neuronal death, highlighting the need to understand how functional interactions between these cells predispose the development of different neurodegenerative conditions.
Veronika Pak, Joon Hwan Hong, Gleb Bezgin, Mahsa Dadar, Yashar Zeighami, Yasser Iturria Medina   +5 more
wiley   +2 more sources

Simultaneous mass spectrometry imaging of multiple neuropeptides in the brain and alterations induced by experimental parkinsonism and L-DOPA therapy

Neurobiology of Disease, 2020
Neuropeptides are important signalling molecules in the brain and alterations in their expression levels have been linked to neurological disorders such as Parkinson's disease. It is challenging to map neuropeptide changes across and within brain regions
Heather Hulme, Elva Fridjonsdottir, Halla Gunnarsdottir, Theodosia Vallianatou, Xiaoqun Zhang, Henrik Wadensten, Reza Shariatgorji, Anna Nilsson, Erwan Bezard, Per Svenningsson, Per E. Andrén   +10 more
doaj   +1 more source

Expression of the Antimicrobial Peptide Piscidin 1 and Neuropeptides in Fish Gill and Skin: A Potential Participation in Neuro-Immune Interaction

Marine Drugs, 2022
Antimicrobial peptides (AMPs) are found widespread in nature and possess antimicrobial and immunomodulatory activities. Due to their multifunctional properties, these peptides are a focus of growing body of interest and have been characterized in several
Giacomo Zaccone, Gioele Capillo, Jorge Manuel Oliveira Fernandes, Viswanath Kiron, Eugenia Rita Lauriano, Alessio Alesci, Patrizia Lo Cascio, Maria Cristina Guerrera, Michal Kuciel, Krystyna Zuwala, Jose Manuel Icardo, Atsushi Ishimatsu, Ryosuke Murata, Takafumi Amagai, Antonino Germanà, Marialuisa Aragona   +15 more
doaj   +1 more source

Recent Advancements in the Characterization of D‐Amino Acid and Isoaspartate Post‐Translational Modifications

Mass Spectrometry Reviews, EarlyView.
ABSTRACT One of the great triumphs of mass spectrometry‐based peptide and protein characterization is the characterization of their modifications as most modifications have a characteristic mass shift. What happens when the modification does not change the mass of the peptide?
Samuel Okyem, Jonathan V. Sweedler
wiley   +1 more source

Thermometer Ions, Internal Energies, and In‐Source Fragmentation in Ambient Ionization

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Ionization and fragmentation are at the core of mass spectrometry. But they are not necessarily separated in space, as in‐source fragmentation can also occur. Here, we survey the literature published since our 2005 review on the internal energy and fragmentation in electrospray ionization sources.
Emilie Bertrand, Valérie Gabelica
wiley   +1 more source

Endogenous opioid systems alterations in pain and opioid use disorder

Frontiers in Systems Neuroscience, 2022
Decades of research advances have established a central role for endogenous opioid systems in regulating reward processing, mood, motivation, learning and memory, gastrointestinal function, and pain relief.
Jessica A. Higginbotham, Jessica A. Higginbotham, Jessica A. Higginbotham, Tamara Markovic, Nicolas Massaly, Nicolas Massaly, Nicolas Massaly, Jose A. Morón, Jose A. Morón, Jose A. Morón, Jose A. Morón, Jose A. Morón   +11 more
doaj   +1 more source

Psychoneuroimmunology-Based Stress Management during Adjuvant Chemotherapy for Early Breast Cancer [PDF]

, 2013
Objective. In a randomized trial of women with early stage breast cancer undergoing adjuvant chemotherapy, two stress management interventions, tai chi training and spiritual growth groups, were compared to a usual care control group, to evaluate ...
Elswick, R. K., Jr., Gray, D. Patricia, McCain, Nancy L., Robins, Jo Lynne W., Tuck, Inez, Walter, Jeanne M.   +5 more
core   +2 more sources

Blood-brain barrier transport kinetics of NOTA-modified proteins : the somatropin case [PDF]

, 2020
BACKGROUND: Chemical modifications such as PEG, polyamine and radiolabeling on proteins can alter their pharmacokinetic behaviour and their blood-brain barrier (BBB) transport characteristics. NOTA, i.e. 1,4,7-triazacyclononane-1,4,7-triacetic acid, is a
Bracke, Nathalie, De Spiegeleer, Bart, Janssens, Yorick, Maes, Alex, Sathekge, Mike, Tack, Liesa, Van De Wiele, Christophe, Wynendaele, Evelien   +7 more
core   +1 more source