Results 61 to 70 of about 12,744 (238)

Molecular basis of domain‐specific angiotensin I‐converting enzyme inhibition by the antihypertensive drugs enalaprilat, ramiprilat, trandolaprilat, quinaprilat and perindoprilat

The FEBS Journal, EarlyView.
Inhibition of angiotensin I‐converting enzyme is an effective strategy for the treatment of hypertension. However, the clinically available ACE inhibitors cause side effects due to nonselective inhibition of the two catalytic domains of ACE (nACE and cACE).
Kyle S. Gregory, Vinasha Ramasamy, Edward D. Sturrock, K. Ravi Acharya   +3 more
wiley   +1 more source

Methionine-enkephalin and leucine-enkephalin in human sympathoadrenal system and pheochromocytoma. [PDF]

Journal of Clinical Investigation, 1982
To elucidate the physiological and pathophysiological significance of methionine- and leucine-enkephalin (Met-and Leu-enkephalin, respectively) in human sympathoadrenal system, the contents of these peptides in normal human sympathetic nervous system, adrenal medulla, and pheochromocytomas were determined by specific radioimmunoassays combined with ...
Hiroo Imura, Shozo Li, Kazuwa Nakao, Hitoshi Ohtsuki, Takaaki Yoshimasa   +4 more
openaire   +2 more sources

The pharmacotherapeutic potential of neuropeptide Y for chronic pain

Journal of Internal Medicine, EarlyView.
Abstract Chronic pain is a major medical problem that requires new therapeutic options. Discovered by Victor Mutt in 1982, neuropeptide Y (NPY) is rapidly emerging as a master regulator of pain relief. Genetic knockdown of NPY or pharmacological inhibition of its receptors demonstrates that NPY signaling tonically inhibits indices of chronic ...
Al A. Nie, Bradley K. Taylor
wiley   +1 more source

Clinical significance of exercise‐induced hypoalgesia in individuals with temporomandibular disorders and neck pain: A clinical trial protocol

Experimental Physiology, EarlyView.
Abstract Evidence reports positive effects of neck motor control and aerobic exercises (AEs) to improve pain in individuals with temporomandibular disorders (TMD) and neck pain. A single bout of exercise typically leads to an increase in pain thresholds up to 30 min post‐exercise, known as exercise‐induced hypoalgesia (EIH).
Luiz Felipe Tavares, Ana Izabela Sobral de Oliveira‐Souza, Vladimir Aron, Ana Beatriz Oliveira, Henrik Bjarke Vaegter, Susan Armijo‐Olivo   +5 more
wiley   +1 more source

The effectiveness of aerobic exercise on pain and disability in individuals with neck pain: A systematic review and meta‐analysis

Experimental Physiology, EarlyView.
Abstract The present review aimed to investigate the effectiveness of aerobic exercise (AE) compared to other interventions in decreasing pain intensity and reducing disability in individuals with neck pain. A systematic review (SR) of randomized controlled trials was conducted. This SR was registered in PROSPERO (CRD42021231231).
Ana lzabela Sobral de Oliveira‐Souza, Marie Kempe, Sofia Grimmelsmann, Luiz Felipe Tavares, Ester Moreira De Castro‐Carletti, Angela Viegas Andrade, Liz Dennett, Harry Von Piekartz, Jorge Fuentes Contreras, Susan Armijo‐Olivo   +9 more
wiley   +1 more source

Stable Nitrogen Isotope Analysis of Amino Acids by Orbitrap Mass Spectrometry: Application for Extraterrestrial Samples

Rapid Communications in Mass Spectrometry, Volume 39, Issue 23, 15 December 2025.
ABSTRACT Background Obtaining isotopic data on soluble organic compounds, such as amino acids, in extraterrestrial samples is crucial for understanding their origins, prebiotic chemistry, and potential contamination. Conventional GC‐IRMS requires grams of material to measure isotopic compositions, limiting the analysis of low‐concentration organics in ...
O. M. McIntosh, A. A. Baczynski, M. Matney, H. L. McLain, K. K. Farnsworth, J. P. Dworkin, D. P. Glavin, J. E. Elsila, H. Xie, K. H. Freeman   +9 more
wiley   +1 more source

Consolidation, Systematic Appraisal and Comparison of Guideline Recommendations Regarding Management of Chronic Pain: Protocol for a Digital Chronic Pain Recommendation Map

Clinical and Public Health Guidelines, Volume 2, Issue 4, October 2025.
ABSTRACT Introduction Chronic pain affects 1 in 5 adults and children globally; however, management remains highly variable and low value care is common. Inconsistent recommendations among clinical practice guidelines for management of chronic pain contribute to suboptimal patient management.
Andrea J. Darzi, Kian Torabiardakani, Gonzalo Bravo‐Soto, Daniela Montalva‐Romero, Rachel J. Couban, Lynn Cooper, Stacey Ritz, Jaris Swidrovich, Ivan D. Florez, Vivian Welch, Gordon H. Guyatt, Holger J. Schünemann, Jason W. Busse, on behalf of the Chronic Pain RecMap Collaborative, Ahmad Firas Khalid, Abhimanyu Sud, Alfonso Iorio, Anaïs Lacasse, Andrew Thomas, Artur Nowak, Bart Dietl, Behnam Sadeghirad, Cyd Courchesne, Dena Zeraatkar, Edoardo Aromataris, Elaine Harrow, Farid Foroutan, Fei Yutong, Gabriel Rada, Glen Hazlewood, Hugo Massé‐Alarie, Jennifer Petkovic, Justyna Litynska, Keven Phinney, Lawrence Mbuagbaw, Li Wang, Lisa Graves, Luc J. Hébert, Marc‐André Blanchette, Peter Tugwell, Rebecca Morgan, Jean‐Sebastien Roy, Thomas Piggott, Trevor Jenvenne, Yaolong Chen, Ying Zhang, Zachary Munn, Zoe Jordan, Rana Yamout   +48 more
wiley   +1 more source

Dendranthema oreastrum (Hance) Y.Ling Attenuates Oxidative Stress and Airway Inflammation in a Murine Model of Lipopolysaccharide‐Induced Acute Lung Injury

Environmental Toxicology, Volume 40, Issue 10, Page 1220-1232, October 2025.
ABSTRACT We examined the antioxidant and anti‐inflammatory effects of the methanolic extract of Dendranthema oreastrum (Hance) Y.Ling, commonly known as “Gu‐Jeol‐Cho” in Korea and widely found across East Asia, using an LPS‐induced acute lung injury (ALI) mouse model and TNF‐α‐stimulated NCI‐H292 cells.
Ji‐Hye Ha, Ba‐Wool Lee, Da‐Hye Yi, Seong‐Hun Jeong, Ju‐Hong Kim, Hyun‐Jae Jang, Ju Hwan Jeong, Ji‐Young Park, Hyung Jae Jeong, Hyung‐Jun Kwon, Young‐Bae Ryu, In‐Chul Lee   +11 more
wiley   +1 more source

Evaluation of Analgesic Activity of Newly Synthesized Phthalyl- tyrosyl-glycin Sodium

Iraqi Journal of Pharmaceutical Sciences, 2017
Alteration in the backbone structure of the endogenously released opioid peptides Leu5/Met5 enkephalins may result in compounds having comparable profile of pharmacological activity but with different physicochemical properties and side effects. Phthalyl
Muthanna S. AL-Taee, Kawkab Y. Saour, Haider M. Mohammed   +2 more
doaj   +3 more sources

UK Medical Cannabis Registry: A Clinical Outcomes Analysis for Complex Regional Pain Syndrome

Brain and Behavior, Volume 15, Issue 9, September 2025.
Complex regional pain syndrome is a rare neuropathic pain disorder. There is a paucity of effective analgesia available for this condition. This study aimed to assess the outcomes of 64 patients prescribe cannabis‐based medicinal products for this condition up to 6 months.
Lilia Evans, Simon Erridge, Madhur Varadpande, Arushika Aggarwal, Isaac Cowley, Evonne Clarke, Katy McLachlan, Ross Coomber, James J. Rucker, Michael Platt, Mikael H. Sodergren   +10 more
wiley   +1 more source