Results 71 to 80 of about 12,769 (228)

Interactions of the opioid and cannabinoid systems in reward: Insights from knockout studies

Frontiers in Pharmacology, 2015
The opioid system consists of three receptors, mu, delta, and kappa, which are activated by endogenous opioid peptides (enkephalins, endorphins and dynorphins). The endogenous cannabinoid system comprises lipid neuromodulators (endocannabinoids), enzymes
Katia eBefort
doaj   +1 more source

Methionine-enkephalin and leucine-enkephalin in human sympathoadrenal system and pheochromocytoma. [PDF]

Journal of Clinical Investigation, 1982
To elucidate the physiological and pathophysiological significance of methionine- and leucine-enkephalin (Met-and Leu-enkephalin, respectively) in human sympathoadrenal system, the contents of these peptides in normal human sympathetic nervous system, adrenal medulla, and pheochromocytomas were determined by specific radioimmunoassays combined with ...
Hiroo Imura, Shozo Li, Kazuwa Nakao, Hitoshi Ohtsuki, Takaaki Yoshimasa   +4 more
openaire   +2 more sources

Rapid‐Onset Therapeutic Effects of Delta Opioid Receptor Agonists on Depression‐Like Behaviors Induced by Chronic Social Defeat Stress

Neuropsychopharmacology Reports, Volume 45, Issue 4, December 2025.
Delta opioid receptor agonists improved social avoidance, depression, and anxiety‐like symptoms induced by chronic social defeat stress within 14 days of chronic administration. Furthermore, the therapeutic effects were observed earlier than with the existing antidepressant paroxetine (28 days).
Akihisa Tokuda, Yasuyuki Nagumo, Keita Kajino, Keita Iio, Katsuyasu Sakurai, Seiya Mizuno, Akiyoshi Saitoh, Tsuyoshi Saitoh, Hiroshi Nagase   +8 more
wiley   +1 more source

μ‐Opioid Receptor Dynamics in the Parameningeal Tissue During Migraine Attacks

Annals of Neurology, Volume 98, Issue 4, Page 777-787, October 2025.
Objective The possible impact of meningeal μ‐opioid receptor (μOR) binding in migraine remains unknown. This study investigated μOR availability in the cranial parameninges involved in migraine initiation via nociceptor activation. Methods We used positron emission tomography with [11C] carfentanil, and measured μOR availability in meninges and ...
Dajung J. Kim, Manyoel Lim, Thiago D. Nascimento, Frank Porreca, Robert A. Koeppe, Nouchine Hadjikhani, Alexandre F. DaSilva   +6 more
wiley   +1 more source

Piper auritum (Kunth) Fungal Endophytes: A Source of Metabolites to Inhibit the Formation of Advanced Glycation End Products

Chemistry &Biodiversity, Volume 22, Issue 10, October 2025.
Endophytic fungi of P. auritum were evaluated for their ability to produce inhibitors of formation of advanced glycation end products (AGEs). Neopestalotiopsis sp. H2 and Diaporthe sp. H5 extracts were the most active. So, we performed their chemical profiling by untargeted and phenolics‐targeted metabolomic approaches to identify the potential ...
Lory Sthephany Rochín‐Hernández, José Antonio Guerrero‐Analco, Juan Luis Monribot‐Villanueva, Luis Bernardo Flores‐Cotera   +3 more
wiley   +1 more source

Immunohistochemical Profile of a Conspicuously Organized Structure in the Dorsal Forebrain of the Peacock Gudgeon, Tateurndina ocellicauda

Journal of Comparative Neurology, Volume 533, Issue 10, October 2025.
In the dorsal telencephalon of gobiiform fishes, there is a conspicuously organized structure, consisting of readily identifiable subregions that are surrounded by layers of cell bodies. Using immunohistochemistry against several antigen targets in this structure, we demonstrate that each of these subregions is characterized by its own individual ...
Ruth Gutjahr, Maximilian S. Bothe, Boris P. Chagnaud   +2 more
wiley   +1 more source

Consolidation, Systematic Appraisal and Comparison of Guideline Recommendations Regarding Management of Chronic Pain: Protocol for a Digital Chronic Pain Recommendation Map

Clinical and Public Health Guidelines, Volume 2, Issue 4, October 2025.
ABSTRACT Introduction Chronic pain affects 1 in 5 adults and children globally; however, management remains highly variable and low value care is common. Inconsistent recommendations among clinical practice guidelines for management of chronic pain contribute to suboptimal patient management.
Andrea J. Darzi, Kian Torabiardakani, Gonzalo Bravo‐Soto, Daniela Montalva‐Romero, Rachel J. Couban, Lynn Cooper, Stacey Ritz, Jaris Swidrovich, Ivan D. Florez, Vivian Welch, Gordon H. Guyatt, Holger J. Schünemann, Jason W. Busse, on behalf of the Chronic Pain RecMap Collaborative, Ahmad Firas Khalid, Abhimanyu Sud, Alfonso Iorio, Anaïs Lacasse, Andrew Thomas, Artur Nowak, Bart Dietl, Behnam Sadeghirad, Cyd Courchesne, Dena Zeraatkar, Edoardo Aromataris, Elaine Harrow, Farid Foroutan, Fei Yutong, Gabriel Rada, Glen Hazlewood, Hugo Massé‐Alarie, Jennifer Petkovic, Justyna Litynska, Keven Phinney, Lawrence Mbuagbaw, Li Wang, Lisa Graves, Luc J. Hébert, Marc‐André Blanchette, Peter Tugwell, Rebecca Morgan, Jean‐Sebastien Roy, Thomas Piggott, Trevor Jenvenne, Yaolong Chen, Ying Zhang, Zachary Munn, Zoe Jordan, Rana Yamout   +48 more
wiley   +1 more source

Exploring the 3D Bioprinting Landscape in the Delivery of Active Pharmaceutical Compounds for Therapeutic and Regenerative Medicine Applications

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 113, Issue 10, October 2025.
Three‐dimensional (3D) bioprinting is revolutionizing drug delivery and regenerative medicine by enabling personalized, controlled‐release therapeutic systems. This review explores advancements in biocompatible bioinks, nanomedicines, and 3D‐printed drug delivery constructs, including scaffolds, implants, and bioactive hydrogels.
Khonzisizwe Somandi, Yahya E. Choonara
wiley   +1 more source

Evaluation of Analgesic Activity of Newly Synthesized Phthalyl- tyrosyl-glycin Sodium

Iraqi Journal of Pharmaceutical Sciences, 2017
Alteration in the backbone structure of the endogenously released opioid peptides Leu5/Met5 enkephalins may result in compounds having comparable profile of pharmacological activity but with different physicochemical properties and side effects. Phthalyl
Muthanna S. AL-Taee, Kawkab Y. Saour, Haider M. Mohammed   +2 more
doaj   +3 more sources

A novel and highly efficient purification procedure for native human dipeptidyl peptidase 3 from human blood cell lysate.

PLoS ONE, 2019
Dipeptidyl amino-peptidase 3 (DPP3) is an aminopeptidase involved in peptide degradation, including hormone peptides as angiotensin II and enkephalins. DPP3 plasma activity increases in septic patients and correlates with mortality risk.
Paul Kaufmann, Matthias Muenzner, Mandy Kästorf, Karine Santos, Tobias Hartmann, Anke Dienelt, Linda Rehfeld, Andreas Bergmann   +7 more
doaj   +1 more source