Results 71 to 80 of about 12,744 (238)

A novel and highly efficient purification procedure for native human dipeptidyl peptidase 3 from human blood cell lysate.

PLoS ONE, 2019
Dipeptidyl amino-peptidase 3 (DPP3) is an aminopeptidase involved in peptide degradation, including hormone peptides as angiotensin II and enkephalins. DPP3 plasma activity increases in septic patients and correlates with mortality risk.
Paul Kaufmann, Matthias Muenzner, Mandy Kästorf, Karine Santos, Tobias Hartmann, Anke Dienelt, Linda Rehfeld, Andreas Bergmann   +7 more
doaj   +1 more source

A comprehensive review of the pharmacodynamics, pharmacokinetics and clinical effects of the neutral endopeptidase inhibitor racecadotril

Frontiers in Pharmacology, 2012
Racecadotril, via its active metabolite thiorphan, is an inhibitor of the enzyme neutral endopeptidase (NEP, EC 3.4.24.11), thereby increasing exposure to NEP including enkephalins and atrial natriuretic peptide.
Marion eEberlin, Thomas eMück, Martin C Michel   +2 more
doaj   +1 more source

Exosome‐Based Therapeutics: A Natural Solution to Overcoming the Blood–Brain Barrier in Neurodegenerative Diseases

MedComm, Volume 6, Issue 9, September 2025.
Therapies for neurodegenerative diseases (NDs) are constrained by the blood–brain barrier (BBB), which limits drug delivery. Exosomes, with their ability to cross BBB and deliver drugs efficiently, emerge as a promising platform for central nervous system‐targeted therapies. ABSTRACT Neurodegenerative diseases present significant therapeutic challenges,
Min Sun, Feng Qin, Qian Bu, Yue Zhao, Xiaofeng Yang, Dingwen Zhang, Xiaobo Cen   +6 more
wiley   +1 more source

Embracing Complexity: Peptides as Tunable Scaffolds in the Construction of Discrete Supramolecular Systems

Angewandte Chemie, Volume 137, Issue 34, August 18, 2025.
The inherent chirality, tunability, biocompatibility, and robustness of peptides provide an exciting opportunity for supramolecular chemistry. In this mini‐review, we explore uses of peptides in discrete supramolecular systems, how chemists can draw inspiration from larger biological assemblies, and discuss how embracing the complexity of peptide ...
Ben E. Barber, Ellen M. G. Jamieson, Leah E. M. White, Charlie T. McTernan   +3 more
wiley   +2 more sources

Silica‐Assisted Solid‐Phase Peptide Synthesis (SiPPS)

Journal of Peptide Science, Volume 31, Issue 9, September 2025.
The use of a non‐swelling resin for solid‐phase peptide synthesis allows the reduction of solvent consumption by up to 50%. ABSTRACT Non‐swelling silica‐based resin was used for peptide synthesis. The strategy used is similar to that of solid‐phase peptide synthesis (SPPS), referred to as silica‐assisted solid‐phase peptide synthesis (SiPPS).
Nonsikelelo Nkwanyana, Ashish Kumar, Amit Chakraborty, Steeves Potvin, Georges Thibaut‐Koumba, Brunello Nardone, Francois Beland, Anamika Sharma, Beatriz G. de la Torre, Fernando Albericio   +9 more
wiley   +1 more source

NEUROTROPHIC EFFECTS OF ETIFOXINE

Неврология, нейропсихиатрия, психосоматика, 2016
Higher anxiety results in the decreased levels of various neurotrophic factors and enkephalins and in impaired production of proinflammatory cytokines. The anxiolytic etifoxine is used to treat anxiety states and adjustment disorders. Etifoxine modulates
I. Yu. Torshin, O. A. Gromova, V. A. Semenov, O. A. Limanova, I. V. Gogoleva   +4 more
doaj   +1 more source

Lentil Flours as Sustainable Source of Proteins for the Food Industry

Sustainable Food Proteins, Volume 3, Issue 3, September 2025.
Lentils, due to their accessibility, sustainability, and high nutritional value, emerge as a promising option as protein flour for food development. This study evaluated different functional and nutritional properties of lentil flours. ABSTRACT The growing transition toward a plant‐based diet, coupled with the need for sustainable dietary protein ...
S. M. Pontoni, A.G. Garzón, G. D. Heinen, S.R. Drago   +3 more
wiley   +1 more source

The role of enkephalins in the perioperative period in patients with oropharyngeal cancer

Сибирский онкологический журнал
Postoperative metabolic disorder, namely the development of protein-energy deficiency is one of the challenges in cancer surgery, especially in head and neck surgeries, which are considered the most traumatic. The development of protein-energy deficiency
D. N. Vasiliev, D. E. Kulbakin, E. L. Choynzonov, S. V. Avdeev, A. A. Lee, I. P. Puteev, A. V. Pak, A. V. Kushner   +7 more
doaj   +1 more source

LC‐MS Analysis and Antimicrobial Activity of Different Extracts of Spondias purpurea L

ChemistrySelect, Volume 10, Issue 34, September 8, 2025.
The present research showed that the extracts tested alone do not present significant antibacterial or antifungal activities at low concentrations against the tested strains. However, they demonstrated potentiating effect of already standardized drugs. Abstract Spondias purpurea L.
Maria Elenilda Paulino da Silva, Joara Nályda Pereira Carneiro, Carlos Vinicius Barros Oliveira, Antonia Thassya Lucas dos Santos, Rafael Pereira da Cruz, Débora Lima Sales, José Weverton Almeida‐Bezerra, Viviane Bezerra da Silva, Adrielle Rodrigues Costa, Jacqueline Cosmo Andrade‐Pinheiro, Gyllyandeson de Araújo Delmondes, Paulo Riceli Vasconcelos Ribeiro, Edy Sousa de Brito, Catarina Martins Tahim, Henrique Douglas Melo Coutinho, Maria Flaviana Bezerra Morais‐Braga   +15 more
wiley   +1 more source

Nicotine Effects and the Endogenous Opioid System

Journal of Pharmacological Sciences, 2014
.: Nicotine (NIC) is an exogenous ligand of the nicotinic acetylcholine receptor (nAChR), and it influences various functions in the central nervous system. Systemic administration of NIC elicits the release of endogenous opioids (endorphins, enkephalins,
Shiroh Kishioka, Norikazu Kiguchi, Yuka Kobayashi, Fumihiro Saika   +3 more
doaj   +1 more source