Results 81 to 90 of about 12,744 (238)

Contributions of synaptic energetic dysfunction by microtubule dynamics and microtubule‐based mitochondrial transport disorder to morphine tolerance

British Journal of Pharmacology, Volume 182, Issue 17, Page 4058-4079, September 2025.
Abstract Background and Purpose Morphine is among the most powerful analgesic, but its long‐term use can cause tolerance. Synaptic ATP supply is critical for maintaining synaptic transmission. Microtubule‐based mitochondrial transport ensures synaptic energy supply.
Zheng Li, Jie Liu, Jie Ju, Xiaoling Peng, Wei Zhao, Jihao Ren, Xiaoqian Jia, Jihong Wang, Ye Tu, Feng Gao   +9 more
wiley   +1 more source

GPCR‐G protein signalling and its mutational landscape in cancer—Driver or passenger

British Journal of Pharmacology, Volume 182, Issue 17, Page 3975-3989, September 2025.
G protein‐coupled receptors (GPCRs) play a crucial role in cellular signalling, regulating various physiological processes. Abnormal expression and mutations of GPCRs have been implicated in several types of cancer, influencing tumour initiation, progression and immune response.
Chenlin Feng, Jasper F. Ooms, Erik H. J. Danen, Laura H. Heitman   +3 more
wiley   +1 more source

The Locus Coeruleus—Noradrenergic System in the Healthy and Diseased Brain: A Narrative Review

European Journal of Neurology, Volume 32, Issue 9, September 2025.
The locus coeruleus (LC) is a small brainstem nucleus that serves as the main source of noradrenaline for the central nervous system, influencing a wide range of cognitive and physiological processes. By integrating anatomical, neurochemical, and functional perspectives, this review provides a comprehensive understanding of the LC‐NA system's role in ...
Sielke Caestecker, Emma Lescrauwaet, Paul Boon, Evelien Carrette, Robrecht Raedt, Kristl Vonck   +5 more
wiley   +1 more source

Enkephalin analogs. Introduction of stereochemical constraints, metal binding sites and fluorescent groups [PDF]

, 1979
Ramakrishnan Nagaraj, T.S. Sudha, Shri Shivaji, P. Balaram   +3 more
openalex   +1 more source

Metabolic Profiling Reveals a Glycolytic Shift and an IRG1/Itaconate/NF2L2 Axis Regulating Neurotoxic Oxidative Stress in Inflammatory Microglia

Journal of Neurochemistry, Volume 169, Issue 9, September 2025.
Microglia, the brain's immune cells, change their metabolism depending on whether they are fighting infection or promoting healing. This study shows that during inflammation, microglia increase a molecule called itaconate, which helps reduce harmful stress in the brain while still allowing an immune response.
Pinelopi Engskog‐Vlachos, Mikael K. R. Engskog, Martin Skandik, Kathleen Grabert, Noah Moruzzi, Marie‐Kim St‐Pierre, Ahmed M. Osman, Theodora Sylaidi, Klas Blomgren, Per‐Olof Berggren, Bertrand Joseph   +10 more
wiley   +1 more source

Stimulation of growth hormone and prolactin release by a potent enkephalin analog [PDF]

, 1978
Eric L. Lien, Donald E. Clark, W. Herbert McGregor   +2 more
openalex   +1 more source

Asthma and enkephalin. [PDF]

BMJ, 1980
R J Butland, J. Pang, D Geddes
openaire   +3 more sources

Comprehensive review on neprilysin (NEP) inhibitors: design, structure-activity relationships, and clinical applications

Frontiers in Pharmacology
Neprilysin (NEP), a zinc-dependent membrane-bound metallopeptidase, regulates various bioactive peptides, particularly in kidneys, vascular endothelium, and the central nervous system.
Xinyue Zhang, Chun Hu, Erkang Tian, Yanxin Shen, Wei Liu, Juan Li   +5 more
doaj   +1 more source

Proposal for the biologically active conformation of opiates and enkephalin. [PDF]

, 1977
Fredric A. Gorin, Garland R. Marshall
openalex   +1 more source

Enkephalin- and somatostatin-like immunoreactivities in human adrenal medulla and pheochromocytoma. [PDF]

, 1979
Jan M. Lundberg, Bertil Hamberger, Marianne Schultzberg, T Hökfelt, P. O. Granberg, Suad Efendić, Lars Terenius, Menek Goldstein, Roger L. Luft   +8 more
openalex   +1 more source