Chemoenzymatic Synthesis of Cryptophycin Anticancer Agents by an Ester Bond-Forming Non-ribosomal Peptide Synthetase Module [PDF]
, 2011 Cryptophycins (Crp) are a group of cyanobacterial depsipeptides with activity against drug-resistant tumors. Although they have been shown to be promising, further efforts are required to return these highly potent compounds to the clinic through a new ...
Bolduc, Kyle L. +4 more
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Fungal Biology and Biotechnology, 2018 Background Fungal cyclodepsipeptides (CDPs) are non-ribosomally synthesized peptides produced by a variety of filamentous fungi and are of interest to the pharmaceutical industry due to their anticancer, antimicrobial and anthelmintic bioactivities ...
Simon Boecker +9 more
doaj +1 more source
In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues [PDF]
, 2012 Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence
Denisiuk, Alexander +8 more
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How a fungus shapes biotechnology: 100 years of Aspergillus niger research [PDF]
, 2018 In 1917, a food chemist named James Currie made a promising discovery: any strain of the filamentous mould Aspergillus niger would produce high concentrations of citric acid when grown in sugar medium.
Cairns, Timothy C. +2 more
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Fumonizin-termelő fuzáriumfajok meghatározása PCR-eljárással és uj fumonizin származékok azonosítása = Identification of fumonisin producing Fusarium species by PCR assay, and detection of new fumonisin analogons [PDF]
, 2013 A Fusarium verticillioides a kukorica egyik fontos kórokozója, ismert mikotoxin-termelő penészgomba. Az egészségügyi kockázatot okozó fumonizinek poliketidekből képződő hasonló szerkezetű mikotoxinok.
Bartók, Tibor +2 more
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ChemPlusChemEnniatins are mycotoxins with well-known antibacterial, antifungal, antihelmintic and antiviral activity, which have recently come to attention as potential mitochondriotoxic anticancer agents. The cytotoxicity of enniatins is traced back to their ionophoric properties, in which the cyclodepsipeptidic structure results in enniatin:cation-complexes of ...
Barbara Daiana Gonzalez +6 more
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Human skin kinetics of cyclic depsipeptide mycotoxins [PDF]
, 2014 Cyclic depsipeptides (CDPs) are an emerging group of naturally occurring bioactive peptides, some of which are already developed as pharmaceutical drugs, e.g. valinomycin. They are produced by bacteria, marine organisms and fungi [1].
De Spiegeleer, Bart +3 more
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Mouse tissue distribution and persistence of the food-born fusariotoxins Enniatin B and Beauvericin. [PDF]
Toxicol Lett, 2016 Rodríguez-Carrasco Y +8 more
europepmc +1 more source
The naturally born fusariotoxin enniatin B and sorafenib exert synergistic activity against cervical cancer in vitro and in vivo. [PDF]
Biochem Pharmacol, 2015 Dornetshuber-Fleiss R +9 more
europepmc +1 more source
Do cyclic depsipeptide mycotoxins beauvericin and enniatins cross the blood-brain barrier? [PDF]
, 2016 Bracke, Nathalie +4 more
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