Results 41 to 50 of about 4,762 (134)

O experimento investigativo e representações de alunos de ensino médio: obstáculos epistemológicos em questão

Educação: Teoria e Prática, 2012
Este trabalho teve por finalidade explorar o potencial teórico-metodológico de uma atividade investigativa como recurso didático para o processo de construção e validação de hipóteses.
Silvia Regina Quijadas Aro Zuliani, Carlos Henrique Bocanegra, Rodrigo José Cristiano Gazola, Daiane dos Santos Martins, Denise Fernandes de Mello   +4 more
doaj  

Blood DDIT4 and TRIM13 Transcript Levels Mark the Early Stages of Machado–Joseph Disease

Annals of Neurology, Volume 98, Issue 1, Page 107-119, July 2025.
Objective An abundance of select transcripts and proteins has been found to be dysregulated in blood samples of Machado–Joseph disease (MJD) carriers. Here, we aimed to: (1) identify blood transcriptional changes as potential biomarkers of MJD; (2) correlate levels of differentially expressed blood transcripts with MJD carriers features; and (3 ...
Ana F. Ferreira, Mafalda Raposo, Emily D. Shaw, Louisa Liu, João Vasconcelos, Teresa Kay, Conceição Bettencourt, Maria Luiza Saraiva‐Pereira, Laura Bannach Jardim, Maria do Carmo Costa, Manuela Lima   +10 more
wiley   +1 more source

Diagnostic reproducibility of the 2018 Classification of Gingival Recessions: Comparing photographic and in‐person diagnoses

Journal of Periodontology, Volume 96, Issue 5, Page 467-477, May 2025.
Abstract Background To assess how the diagnostic reproducibility of the 2018 Classification of Gingival Recession Defects (GRD) could be applied when comparing in‐person chairside measurements with photographic measurements. Methods Thirty‐four GRD were photographed and evaluated by 4 masked operators.
Riccardo Di Gianfilippo, GiovanPaolo Pini Prato, Debora Franceschi, Walter Castelluzzo, Luigi Barbato, Alessandra Bandel, Maria Di Martino, Claudio M. Pannuti, Leandro Chambrone, Francesco Cairo   +9 more
wiley   +1 more source

The Use of Video‐Based Learning to Elucidate the Biological Mechanisms Linking Oral Health With Specific Systemic Medical Conditions

Special Care in Dentistry, Volume 45, Issue 3, May/June 2025.
ABSTRACT Introduction Video‐based learning has emerged as a powerful tool to overcome the well‐documented limitations of traditional lectures. Hence, the aim of this study was to investigate the impact of the implementation of a video animation on academic performance and student's opinion.
Yago Leira, Pilar Batalla, Mariana Morgado, Vanessa Machado, José João Mendes, João Botelho, Juan Blanco   +6 more
wiley   +1 more source

UM ENSINO FUNDAMENTADO NA ESTRUTURA DA CONSTRUÇÃO DO CONHECIMENTO CIENTÍFICO

Schème: Revista Eletrônica de Psicologia e Epistemologia Genéticas, 2017
Neste texto iremos apresentar, muito sucintamente, os principais referenciais teóricos para um planejamento de atividades investigativas para o Ensino de Ciências.
Anna Maria Pessoa CARVALHO
doaj   +1 more source

Off‐The‐Shelf Multivalent Nanoconjugate Cancer Vaccine Rescues Host Immune Response against Melanoma

Advanced Materials, Volume 37, Issue 16, April 23, 2025.
A star‐shaped cross‐linked polyglutamate (StCl) nanocarrier delivers melanoma‐associated peptide antigens via redox‐responsive linkers, inducing lymph node‐targeted antigen presentation. The nanoconjugate activates dendritic cells, promotes effector T‐cell responses, and enables tumor regression even in humanized patient‐derived preclinical models ...
Liane IF Moura, Alessio Malfanti, Ana I Matos, Carina Peres, Ana Armiñán, Aroa Duro‐Castaño, Inmaculada Conejos‐Sánchez, María Medel, Snežana Đorđević, Paula Carrascosa, Bárbara Carreira, Rita C Acúrcio, Helena Xavier‐Ferreira, Alberto Hernández‐Barranco, Elena Castellano, Esther Roselló, José C. Machado, Héctor Peinado, María J. Vicent, Helena F. Florindo   +19 more
wiley   +1 more source

Sequências de ensino investigativas: um desafio na formação inicial de professores de Ciências

Revista de Ensino de Ciências e Matemática, 2020
As Sequências de Ensino Investigativas (SEIs) são um conjunto de atividades-chave que compreendem um determinado item do cronograma escolar e tem por objetivo contribuir para a formação científica de estudantes. Na aplicação de um minicurso que discorria
Lília do Espírito Santo Azevedo, Valeria de Souza Marcelino, Cassiana Barreto Hygino Machado   +2 more
doaj   +1 more source

Citizen Science to Raise Antimicrobial Resistance Awareness in the Community: The MicroMundo Project in Spain and Portugal

Microbial Biotechnology, Volume 18, Issue 3, March 2025.
We review here the activity over the years of MicroMundo, a consolidated citizen science and service‐learning Project operating from over 30 Spanish and Portuguese universities, which involves students from different educational levels in the search for antibiotic activities in microorganisms isolated from soil samples.
Jessica Gil‐Serna, Patricia Antunes, Susana Campoy, Ángeles Cid, Antonio Cobo‐Molinos, Paulo Durão, Carmen Fajardo, Belén Fouz, Ana R. Freitas, Filipa Grosso, Piet W. J. de Groot, Trinidad de Miguel, Bruno González Zorn, Belén Hinojosa, Maria João Leão, Montserrat Llagostera, Rosa de Llanos, Ainhoa Lucía, Sergi Maicas, Irma Marín, Magdalena Martínez‐Cañamero, Carla Miranda, José Manuel Molina‐Guijarro, Diego A. Moreno, María de los Llanos Palop, María José Pérez‐Álvarez, Pedro M. Pereira, María Teresa Pérez‐Gracia, Sandra Quinteira, Carmen Rioboo, Beatriz Robredo, José María Rodríguez‐Calleja, Rafael R. de la Haba, Sandra Sánchez, Manuel Sánchez Angulo, Cristina Sánchez‐Porro, Félix J. Sangari, Beatriz Santos, Eduarda Silveira, Begonya Vicedo, Víctor J. Cid, on behalf of all members of MicroMundo Teams in Spain and Portugal   +41 more
wiley   +1 more source

Identification of novel candidate predisposing genes in familial nonmedullary thyroid carcinoma implicating DNA damage repair pathways

International Journal of Cancer, Volume 156, Issue 1, Page 130-144, 1 January 2025.
What's new? Susceptibility genes already associated with nonsyndromic familial nonmedullary thyroid carcinoma (FNMTC) account for only a small portion of the disease's genetic burden. Hence, other predisposing genetic alterations are suspected. Here, the authors applied next‐generation sequencing to analyze cancer‐predisposing genes in probands from ...
Carolina Pires, Inês J. Marques, Ana Saramago, Margarida M. Moura, Marta Pojo, Rafael Cabrera, Catarina Santos, Francisco Rosário, Diana Lousa, João B. Vicente, Tiago M. Bandeiras, Manuel R. Teixeira, Valeriano Leite, Branca M. Cavaco   +13 more
wiley   +1 more source

Mapa da pesquisa do ensino por investigação na formação de professores de ciências: um estudo a partir de dissertações e teses defendidas entre os anos de 2014 e 2023

Alexandria
O Ensino por Investigação tem se consolidado como uma abordagem que promove a participação ativa dos estudantes no processo investigativo da Ciência, superando a mera memorização de fatos. Esta pesquisa qualitativa mapeia o campo de estudo do Ensino por
Alex Antunes Mendes, Celiane Costa Machado, Maykon Gonçalves Müller   +2 more
doaj   +1 more source