Results 81 to 90 of about 4,026 (142)

Antiviral effect of entecavir in chronic hepatitis B: Influence of prior exposure to nucleos(t)ide analogues

, 2010
Background & Aims: Entecavir is a potent inhibitor of viral replication in nucleos(t)ide analogue (NA)-naive chronic hepatitis B patients, but data on the efficacy in NA-experienced subjects are limited.
Janssen, HLA, Santantonio, T, Buti, M, Petersen, J, van Bommel, F, Hansen, Bettina, Deterding, K, Wedemeyer, H, Reijnders, Jurriën, Zoulim, F   +9 more
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Hepatitis B relapse after entecavir or tenofovir alafenamide cessation under anti-viral prophylaxis for cancer chemotherapy

Virology Journal
Background No study has comparing hepatitis B virus (HBV) relapse rates among patients with both cancer and hepatitis B e antigen (HBeAg)-negative chronic hepatitis B (CHB) who completed anti-viral prophylaxis for chemotherapy and then stopped taking ...
Hsin-Wei Fang, Po-Lin Tseng, Tsung-Hui Hu, Jing-Houng Wang, Chao-Hung Hung, Sheng-Nan Lu, Chien-Hung Chen   +6 more
doaj   +1 more source

Management of Antiviral Resistance in Chronic Hepatitis B

Gut and Liver, 2017
The primary goal of therapy for chronic hepatitis B (CHB) is to prevent liver disease progression. Hepatitis B surface antigen (HBsAg) seroclearance or seroconversion is regarded as an optimal endpoint to discontinue treatment.
Young-Suk Lim
doaj   +1 more source

Entecavir shows limited efficacy in HBeAg-positive hepatitis B patients with a partial virologic response to adefovir therapy

, 2009
Background/Aims: We investigated the efficacy of entecavir in lamivudine-experienced and -naive patients with persistently high HBV DNA during adefovir treatment.
Robert A. de Man, Suzan D. Pas, Pas, Suzan, Janssen, HLA, de Man, Rob, Jurriën G.P. Reijnders, Martin Schutten, Harry L.A. Janssen, Schutten, M (Martin), Reijnders, Jurriën   +9 more
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Comparison Between Entecavir and Lamivudine as Hepatitis B Reactivation Prophylaxis in Cancer Patient with Chemotherapy [PDF]

, 2015
Aim: to compare between entecavir and lamivudine as hepatitis B reactivation prophylaxis in cancer patient with chemotherapyMethod: a literature searching in PubMed was done. At the beginning, 8 articles were found. Chosen article in this EBCR were those
Hamonangan, Rachmat, Dharaniyadewi, Dana, Nia Novianti Siregar, Dharaniyadewi, D. (Dana), Siregar, N. N. (Nia), Hamonangan, R. (Rachmat), Dana Dharaniyadewi, Siregar, Nia Novianti, Rachmat Hamonangan   +8 more
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A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B

, 2006
Background: Entecavir is a potent and selective guanosine analogue with significant activity against hepatitis B virus (HBV). Methods: In this phase 3, double-blind trial, we randomly assigned 715 patients with hepatitis B e antigen (HBeAg)-positive ...
Colonno, R. (Richard), Lok, A.S. (Anna), Han, K., Wilber, R. (Richard), Cross, A. (Anne), Goodman, Z. (Zachary), Apelian, D. (David), DeHertogh, D. (Deborah), Gish, R.G., Chang, T., Zhu, J. (Jin), Man, R.A. (Robert) de, Gadano, A., Sollano, J. (José), Chao, Y-C. (You Chen), Cross, A, Ting-Ssung, C, Lok, ASF, Goodman, Z, Sollano, J, Wilber, R, Gadano, A, Jin, Z, You-Chen, C, Gish, RG, de Man, Rob, Colonno, R, Kwang-Hyub, H, Apelian, D, Dehertogh, D   +29 more
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Entecavir allows an unexpectedly high residual replication of HBV mutants resistant to lamivudine.

, 2015
Entecavir is an efficient inhibitor of HBV reverse transcriptase (RT) and widely used for therapy of chronic hepatitis B. Entecavir treatment of HBV patients with lamivudine-resistant viral strains, however, often fails, but the mechanism of cross ...
Geipel, Andreas;Seiz, Pia L;Niekamp, Hauke;Neumann-Fraune, Maria;Zhang, Ke;Kaiser, Rolf;Protzer, Ulrike;Gerlich, Wolfram H;Glebe, Dieter
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Entecavir induced the accumulation of γ-H2AX in nuclei of DT40 cells.

, 2016
(A) Immuno-staining of wild-type (WT) and mutant DT40 clones using anti-γ-H2AX antibody and DAPI. Cells were fixed 6 hours after treated with entecavir 100nM. ETV, entecavir. (B) Quantification of γ-H2AX foci in individual cells of the indicated genotype.
Yong Qing (213715), Xiaoqing Hu (423879), Fang He (43884), Xiaohua Wu (120920), Ying Liu (18461), Lei Jiang (73366), Shunichi Takeda (10500)   +6 more
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Model of entecavir-induced genotoxicity related to single-strand break (SSB) repair and postreplication repair (PRR) pathway.

, 2016
The triphosphate of entecavir is incorporated into DNA strand by host replication or repair polymerases, which blocking extension of the nascent strand and inducing DNA SSB and Parp1 dependent repair.
Yong Qing (213715), Xiaoqing Hu (423879), Fang He (43884), Xiaohua Wu (120920), Ying Liu (18461), Lei Jiang (73366), Shunichi Takeda (10500)   +6 more
core   +1 more source

Comparative analysis of tenofovir alafenamide and entecavir on renal function and serum lipids in liver transplant recipients: a controlled retrospective cohort study

BMC Gastroenterology
Background Antiviral treatments can impact serum lipids as well as kidney function. We conducted a retrospective observational study with a 48-month follow-up period, involving liver transplant recipients receiving either entecavir or tenofovir ...
Hüseyin Döngelli, Nilay Danış, Tarkan Ünek, Tufan Egeli, Cihan Ağalar, Mücahit Özbilgin, Hülya Ellidokuz, Mesut Akarsu   +7 more
doaj   +1 more source