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Therapeutic Options for Metallo-β-Lactamase-Producing Enterobacterales

Infection and Drug Resistance, 2021
The spread of metallo-β-lactamase (MBL)-producing Enterobacterales worldwide without the simultaneous increase in active antibiotics makes these organisms an urgent public health threat. This review summarizes recent advancements in diagnostic and treatment strategies for infections caused by MBL-producing Enterobacterales.
Kimberly Baugh, Yanqin Huang, Neeraja Kadiyala   +2 more
exaly   +6 more sources

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Characteristics of community-acquired carbapenem-resistant Enterobacterales

Journal of Antimicrobial Chemotherapy, 2022
AbstractBackgroundCommunity-acquired carbapenem-resistant Enterobacterales (CA-CRE) are an important threat.MethodsIn CRACKLE-2, we defined patients with CA-CRE as admitted from home, without pre-existing conditions, and a positive culture within 48 h of admission.
Rima Shrestha, Courtney L Luterbach, Weixiao Dai, Lauren Komarow, Michelle Earley, Gregory Weston, Erica Herc, Jesse T Jacob, Robert Salata, Darren Wong, Deverick Anderson, Kirsten B Rydell, Cesar A Arias, Liang Chen, David van Duin, Gregory Weston, Belinda Ostrowsky, Judith J Lok, Robert A Bonomo, T Nicholas Domitrovic, Kristine M Hujer, Andrea M Hujer, Susan D Rudin, Steven H Marshall, Robert A Salata, Federico Perez, Eric Cober, Sandra S Richter, Rebekka Arias, Carol Hill, Vance G Fowler, Deverick J Anderson, Jesse T Jacob, Minggui Wang, Liang Chen, Samit Desai, Barry N Kreiswirth, Claudia Manca, Jose R Mediavilla, Gopi Patel, W Charles Huskins, Robin Patel, Sara Revolinski, Glenn Wortmann, Robert C Kalayjian, Angela Kim, Julia Garcia-Diaz, Bettina C Fries, Brandon Eilertson, Jason C Gallagher, Michelle Earley, Scott Evans, Lauren Komarow, Omai B Garner, Henry F Chambers, John J Farrell, Lilian M Abbo, Keith S Kaye, Courtney Luterbach, David van Duin, Jennifer H Han, Yohei Doi, David L Paterson, Darren Wong, Cesar A Arias, Blake Hanson, An Dinh, Diana Panesso, William Shropshire, Truc T Tran, Ritu Banerjee, Sorabh Dhar, Michael J Satlin, Matthew Grant   +73 more
openaire   +2 more sources

Rapid detection of Enterobacterales that produce carbapenemases

Diagnostic Microbiology and Infectious Disease, 2020
The rapid detection of carbapenemases among Enterobacterales in clinical laboratories is critical for management of patients, and infection prevention and control efforts.A study was designed to evaluate the performances of the RAPIDEC CARBA NP®, β-CARBA®, NG-Test CARBA 5®, modified carbapenem-inactivation method, and EDTA version (eCIM) assays against
Wilson W, Chan, Lorraine, Campbell, Diana, Doyle, Johann Dd, Pitout   +3 more
openaire   +2 more sources

Rapid ResaCeftazidime-Avibactam Enterobacterales NP Test: Rapid Detection of Ceftazidime-Avibactam Susceptibility in Enterobacterales

Journal of Clinical Microbiology, 2022
Ceftazidime-avibactam (CZA), a novel β-lactam/β-lactamase inhibitor combination, has good antibacterial activity against carbapenem-resistant Enterobacterales (CRE) producing class A and C and some class D carbapenemases, but in recent years, the emergence of CZA-resistant Enterobacterales ...
Luozhu Feng, Yining Zhao, Zhuocheng Yao, Xiaodong Zhang, Shufang Zheng, Lijiang Chen, Ying Zhang, Lingbo Wang, Tieli Zhou, Jianming Cao   +9 more
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Comparing mortality in patients with carbapenemase-producing carbapenem resistant Enterobacterales and non-carbapenemase-producing carbapenem resistant Enterobacterales bacteremia

Diagnostic Microbiology and Infectious Disease, 2021
Carbapenem-resistant Enterobacterales (CRE) are classified as either carbapenemase-producing CRE (CP-CRE) or non-carbapenemase-producing CRE (non-CP-CRE) based on their mechanism of carbapenem resistance. Few studies have compared outcomes associated with each type of infection.
Michael R, Hovan, Navaneeth, Narayanan, Vanessa, Cedarbaum, Tanaya, Bhowmick, Thomas J, Kirn   +4 more
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Clinical outcomes in patients infected with ertapenem-only-resistant Enterobacterales versus multi-carbapenem-resistant Enterobacterales

Journal of Antimicrobial Chemotherapy
Abstract Background Use of anti-carbapenem-resistant Enterobacterales (anti-CRE) agents such as ceftazidime/avibactam has been associated with improved clinical outcome in cohorts that primarily include patients infected with CRE that are resistant to meropenem (MCRE).
Gregory Weston, Abhigya Giri, Lauren Komarow, Lizhao Ge, Keri R Baum, Erin Abbenante, Jason C Gallagher, Jesse T Jacob, Keith S Kaye, Angela C Kim, W Charles Huskins, Marcus Zervos, Erica Herc, Robin Patel, David Van Duin, Yohei Doi   +15 more
openaire   +2 more sources

Trends in Enterobacterales Bloodstream Infections in Children

Pediatrics
OBJECTIVES Enterobacterales bloodstream infections (E-BSI) cause a significant burden of disease in children and are associated with antimicrobial resistance. We assessed temporal changes in the population-based incidence of E-BSI in children in Queensland, Australia.
Gibbs, Anna A.M., Laupland, Kevin B., Edwards, Felicity, Ling, Weiping, Channon-Wells, Samuel, Harley, David, Falster, Kathleen, Paterson, David L., Harris, Patrick N.A., Irwin, Adam D.   +9 more
openaire   +3 more sources