Results 51 to 60 of about 1,015,161 (283)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Assessment of extended-spectrum β-lactamases and integrons among Enterobacteriaceae in device-associated infections: multicenter study in north of Iran

Antimicrobial Resistance and Infection Control, 2016
Background Device-associated nosocomial infections (DA-NIs), due to MDR Enterobacteriaceae, are a major threat to patient safety in ICUs. We investigated on Extended-spectrum β-lactamases (ESBL) producing Enterobacteriaceae and incidence of integrons in ...
Masoumeh Bagheri-Nesami, Alireza Rafiei, Gohar Eslami, Fatemeh Ahangarkani, Mohammad Sadegh Rezai, Attieh Nikkhah, Azin Hajalibeig   +6 more
doaj   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Detection of OXA-48-Carbapenemase-Producing Enterobacteriaceae using ChromID OXA-48 in Critical Care Patients in Egypt

Journal of Pure and Applied Microbiology, 2017
Carbapenems are a class of beta-lactam antibiotics with broad spectrum of activity. They are often considered as a last resort in treatment of infections caused by multidrug resistant organisms.
Basma A. El Awady, Mera G. Anan, Hamida A. Gohar, Mohamed H. Saleh   +3 more
doaj   +1 more source

Healthcare-Associated Infections: Enterobacteriaceae Bloodstream Infections in the ICU Settings [PDF]

Infection Control & Hospital Epidemiology, 2020
Background: Bloodstream infections (BSIs) are one of the most frequently observed hospital-acquired infections (HAIs). Objectives: We aimed to describe the epidemiology and drug resistance of hospital-acquired Enterobacteriaceae BSIs and to check for any correlation with the type of hospital care.
Marta KŁOS, Monika Pomorska-Wesołowska, Dorota Romaniszyn, Agnieszka Chmielarczyk, Jadwiga Wojkowska-Mach   +4 more
openaire   +1 more source

Prevalence of Enterobacteriaceae co-infections in humans from villages in Southeastern Madagascar.

, 2014
Prevalence of Enterobacteriaceae co-infections in humans from villages in Southeastern Madagascar.
DeAnna C. Bublitz (591000), Patricia C. Wright (368557), Jonathan R. Bodager (591001), James B. Bliska (170551), Thomas R. Gillespie (326919), Fidisoa T. Rasambainarivo (591002)   +5 more
core   +1 more source

Critical Roles of O‐Acetylation Revealed by Synthetic Trisaccharide Antigens for a Broad‐Spectrum Anti‐Salmonella Vaccine

Advanced Science, EarlyView.
A synthetic glycoconjugate vaccine based on a diacetylated Salmonella trisaccharide elicits broadly protective antibodies against four major human pathogenic serovars. Mechanistic studies identify 2,3‐di‐O‐acetylation of rhamnose as a critical determinant of antigen recognition and breadth of protection, establishing a new strategy for broad‐spectrum ...
Xingling Pan, Soham Maity, Herbert Kavunja, Yuvarani Murali, Ting‐An Chen, Chang‐xin Huo, Scott M. Baliban, Xuefei Huang   +7 more
wiley   +1 more source

The Gut of Healthy Infants in the Community as a Reservoir of ESBL and Carbapenemase-Producing Bacteria

Antibiotics, 2020
The recent rapid rise of multi-drug resistant Enterobacteriaceae (MDR-E) is threatening the treatment of common infectious diseases. Infections with such strains lead to increased mortality and morbidity.
Ali F. Saleem, Ahreen Allana, Lauren Hale, Alondra Diaz, Raul Salinas, Cristina Salinas, Shahida M. Qureshi, Aneeta Hotwani, Najeeb Rahman, Asia Khan, Anita K. Zaidi, Patrick C. Seed, Mehreen Arshad   +12 more
doaj   +1 more source

Blood stream infections due to OXA-48-like carbapenemase-producing Enterobacteriaceae: treatment and survival

, 2021
Background: Blood stream infections (BSIs) due to carbapenem-resistant Enterobacteriaceae (CRE) are associated with high hospital mortality rates and present a tremendous challenge to clinicians. The optimal treatment remains undefined.
Mutcali, Sibel Islak, Tabak, Fehmi, Kuskucu, Mert, Ozturk, Recep, Kara, Zehra, Aras, Sukru, Aygun, Gokhan, Mete, Bilgul, Aydin, Selda, Ozaras, Resat, Balkan, Ilker Inanc, Midilli, Kenan, Semen, Vicdan, Saltoglu, Neşe, Yemisen, Mucahit   +14 more
core   +1 more source

Structural Variants in the Human Genome Associated With Gut Microbiome and Blood Metabolic Traits With Potential Causal Links

Advanced Science, EarlyView.
Based on a multi‐omics cohort of 2002 individuals comprising high‐depth whole‐genome and metagenomic sequencing data, blood metabolites, and detailed questionnaires, we identified 138 859 high‐confidence SVs, uncovering 36 significant SV–microbiome associations and 48 SV–blood metabolite associations.
Qun Zhou, Keqing Wang, Junhong Chen, Haoyu Wang, Xinjiang Tan, Xuanlin Huang, Zhiyin Lin, Xun Xu, Xin Jin, Shaoqiao Zhang, Liang Xiao, Yuanqiang Zou, Tao Zhang, Xiaomin Liu   +13 more
wiley   +1 more source