Enteroendocrine cell regulation of the gut-brain axis [PDF]
Frontiers in Neuroscience, 2023 Enteroendocrine cells (EECs) are an essential interface between the gut and brain that communicate signals about nutrients, pain, and even information from our microbiome.
Joshua R. Barton +6 more
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Enteroendocrine cell lineages that differentially control feeding and gut motility [PDF]
eLife, 2023 Enteroendocrine cells are specialized sensory cells of the gut-brain axis that are sparsely distributed along the intestinal epithelium. The functions of enteroendocrine cells have classically been inferred by the gut hormones they release.
Marito Hayashi +6 more
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Short-chain fatty acids, secondary bile acids and indoles: gut microbial metabolites with effects on enteroendocrine cell function and their potential as therapies for metabolic disease. [PDF]
Front Endocrinol (Lausanne), 2023 The gastrointestinal tract hosts the largest ecosystem of microorganisms in the body. The metabolism of ingested nutrients by gut bacteria produces novel chemical mediators that can influence chemosensory cells lining the gastrointestinal tract ...
Masse KE, Lu VB.
europepmc +4 more sources
Enteroendocrine cell differentiation and function in the intestine. [PDF]
Curr Opin Endocrinol Diabetes Obes, 2022 Purpose of review The intestinal enteroendocrine cells (EECs) are specialized hormone-secreting cells that respond to both circulating and luminal cues.
Sanchez JG, Enriquez JR, Wells JM.
europepmc +4 more sources
A hierarchical transcription factor cascade regulates enteroendocrine cell diversity and plasticity in Drosophila [PDF]
Nature Communications, 2022 Here the authors elucidate a simple transcription factor code that underlies the complex genetic specification of enteroendocrine cell (EE) subtypes, and reveal significant cellular plasticity amongst EE subtypes.
Xingting Guo +3 more
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Transcription Factor Antagonism Controls Enteroendocrine Cell Specification from Intestinal Stem Cells [PDF]
Scientific Reports, 2017 The balanced maintenance and differentiation of local stem cells is required for Homeostatic renewal of tissues. In the Drosophila midgut, the transcription factor Escargot (Esg) maintains undifferentiated states in intestinal stem cells, whereas the ...
Yumei Li +5 more
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An enteroendocrine cell-enteric glia connection revealed by 3D electron microscopy. [PDF]
PLoS ONE, 2014 The enteroendocrine cell is the cornerstone of gastrointestinal chemosensation. In the intestine and colon, this cell is stimulated by nutrients, tastants that elicit the perception of flavor, and bacterial by-products; and in response, the cell secretes
Diego V Bohórquez +5 more
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Deregulation of transcription factors controlling intestinal epithelial cell differentiation; a predisposing factor for reduced enteroendocrine cell number in morbidly obese individuals [PDF]
Scientific Reports, 2017 Morbidly obese patients exhibit impaired secretion of gut hormones that may contribute to the development of obesity. After bariatric surgery there is a dramatic increase in gut hormone release.
Beglinger, C +9 more
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Kisspeptin-10 Ameliorates Obesity-Diabetes with Diverse Effects on Ileal Enteroendocrine Cells and Pancreatic Islet Morphology in High-Fat Fed Female Mice [PDF]
BiomoleculesKisspeptin is a neuropeptide recognised for a pivotal role within the reproductive system, but potentially important endocrine metabolic effects are less well understood. We examined effects of twice-daily intraperitoneal administration of saline vehicle
Ananyaa Sridhar +6 more
doaj +4 more sources
Enteroendocrine cell types that drive food reward and aversion. [PDF]
Elife, 2022 Animals must learn through experience which foods are nutritious and should be consumed, and which are toxic and should be avoided. Enteroendocrine cells (EECs) are the principal chemosensors in the GI tract, but investigation of their role in behavior ...
Bai L +9 more
europepmc +2 more sources