Results 11 to 20 of about 10,640,678 (241)

Description and functional validation of human enteroendocrine cell sensors. [PDF]

Science
Enteroendocrine cells (EECs) are gut epithelial cells that respond to intestinal contents by secreting hormones, including the incretins glucagon-like peptide 1 (GLP-1) and gastric inhibitory protein (GIP), which regulate multiple physiological processes.
Beumer J, Geurts MH, Geurts V, Andersson-Rolf A, Akkerman N, Völlmy F, Krueger D, Busslinger GA, Martínez-Silgado A, Boot C, Yousef Yengej FA, Puschhof J, Van de Wetering WJ, Knoops K, López-Iglesias C, Peters PJ, Vivié JA, Mooijman D, van Es JH, Clevers H.   +19 more
europepmc   +7 more sources

Evolving Concepts and Translational Relevance of Enteroendocrine Cell Biology [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2015
Classical enteroenteroendocrine cell (EEC) biology evolved historically from identification of scattered hormone-producing endocrine cells within the epithelial mucosa of the stomach, small and large intestine. Purification of functional EEC hormones from intestinal extracts, coupled with molecular cloning of cDNAs and genes expressed within EECs has ...
Daniel J. Drucker
semanticscholar   +4 more sources

Regulation of Enteroendocrine Cell Networks by the Major Human Gut Symbiont <i>Bacteroides thetaiotaomicron</i>. [PDF]

Front Microbiol, 2020
Gut microbes have critical roles in maintaining host physiology, but their effects on epithelial chemosensory enteroendocrine cells (EEC) remain unclear.
Modasia A, Parker A, Jones E, Stentz R, Brion A, Goldson A, Defernez M, Wileman T, Ashley Blackshaw L, Carding SR.   +9 more
europepmc   +2 more sources

Glutamine-induced signaling pathways via amino acid receptors in enteroendocrine L cell lines [PDF]

Journal of Molecular Endocrinology, 2020
Glucagon-like peptide-1 (GLP-1), secreted by gastrointestinal enteroendocrine L cells, induces insulin secretion and is important for glucose homeostasis. GLP-1 secretion is induced by various luminal nutrients, including amino acids.
Takumi Nakamura, Kazuki Harada, T. Kamiya, Mai Takizawa, Jim Küppers, Kazuo Nakajima, Michael Gütschow, Tetsuya Kitaguchi, Kunihiro Ohta, Tadafumi Kato, Takashi Tsuboi   +10 more
openalex   +2 more sources

Transcellular propagation of fibrillar α-synuclein from enteroendocrine to neuronal cells requires cell-to-cell contact and is Rab35-dependent

Scientific Reports, 2022
Parkinson’s disease (PD) is a neurodegenerative condition featured by motor dysfunction, death of midbrain dopaminergic neurons and accumulation of α-synuclein (αSyn) aggregates.
Paulla Vieira Rodrigues, João Vitor Pereira de Godoy, Beatriz Pelegrini Bosque, Dionísio Pedro Amorim Neto, Katiane Tostes, Soledad Palameta, Sheila Garcia-Rosa, Celisa Caldana Costa Tonoli, Hernandes Faustino de Carvalho, Matheus de Castro Fonseca   +9 more
doaj   +2 more sources

The Cellular Diversity and Transcription Factor Code of Drosophila Enteroendocrine Cells

Cell Reports, 2019
Summary: Enteroendocrine cells (EEs) in the intestinal epithelium have important endocrine functions, yet this cell lineage exhibits great local and regional variations that have hampered detailed characterization of EE subtypes.
Xingting Guo, Chang Yin, Fu Yang, Yongchao Zhang, Huanwei Huang, Jiawen Wang, Bowen Deng, Tao Cai, Yi Rao, Rongwen Xi   +9 more
doaj   +2 more sources

Enteroendocrine Cells Support Intestinal Stem-Cell-Mediated Homeostasis in Drosophila

Cell Reports, 2014
Summary: Intestinal stem cells in the adult Drosophila midgut are regulated by growth factors produced from the surrounding niche cells including enterocytes and visceral muscle. The role of the other major cell type, the secretory enteroendocrine cells,
Alla Amcheslavsky, Wei Song, Qi Li, Yingchao Nie, Ivan Bragatto, Dominique Ferrandon, Norbert Perrimon, Y. Tony Ip   +7 more
doaj   +5 more sources

Type 2 diabetes is associated with impaired jejunal enteroendocrine GLP-1 cell lineage in human obesity [PDF]

International Journal of Obesity, 2020
Objectives Altered enteroendocrine cell (EEC) function in obesity and type 2 diabetes is not fully understood. Understanding the transcriptional program that controls EEC differentiation is important because some EEC types harbor significant therapeutic ...
Céline Osinski, Léa Le Gléau, Christine Poitou, Juan de Toro‐Martín, Laurent Genser, Magali Fradet, Hédi Soula, Armelle Leturque, Corinne Blugeon, Laurent Jourdren, Edwige Ludiwyne Hubert, Karine Clément, Patricia Serradas, Agnès Ribeiro   +13 more
openalex   +2 more sources

An enteroendocrine cell-enteric glia connection revealed by 3D electron microscopy.

PLoS ONE, 2014
The enteroendocrine cell is the cornerstone of gastrointestinal chemosensation. In the intestine and colon, this cell is stimulated by nutrients, tastants that elicit the perception of flavor, and bacterial by-products; and in response, the cell secretes
Diego V Bohórquez, Leigh A Samsa, Andrew Roholt, Satish Medicetty, Rashmi Chandra, Rodger A Liddle   +5 more
doaj   +2 more sources

Akkermansia muciniphila induces mitochondrial calcium overload and α -synuclein aggregation in an enteroendocrine cell line. [PDF]

iScience, 2022
Amorim Neto DP, Bosque BP, Pereira de Godoy JV, Rodrigues PV, Meneses DD, Tostes K, Costa Tonoli CC, Faustino de Carvalho H, González-Billault C, de Castro Fonseca M.   +9 more
europepmc   +2 more sources