Results 41 to 50 of about 10,640,678 (241)
Revisiting the concept of incretin and enteroendocrine L-cells as type 2 diabetes mellitus treatment
Pharmacological Research, 2022 The significant growth in type 2 diabetes mellitus (T2DM) prevalence strikes a common threat to the healthcare and economic systems globally. Despite the availability of several anti-hyperglycaemic agents in the market, none can offer T2DM remission ...
Kok-Hou Lok +4 more
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Diet: Friend or Foe of Enteroendocrine Cells: How It Interacts with Enteroendocrine Cells [PDF]
Advances in Nutrition, 2012 Gut hormones play a key role in the regulation of food intake, energy expenditure, glucose homeostasis, lipid metabolism, and a wide range of metabolic functions in response to food ingestion. These hormones are altered in metabolic diseases, such as obesity and type 2 diabetes, and are thus proposed to be possible targets for the prevention or ...
Sofia, Moran-Ramos +2 more
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Free Fatty Acid Receptors in Enteroendocrine Cells [PDF]
Endocrinology, 2018 Free fatty acid receptors (FFAs) are highly enriched in enteroendocrine cells providing pathways to link dietary fats and microbially generated short-chain fatty acids (SCFAs) to the secretion of a variety of gut hormones. FFA1 and FFA4 are receptors for long-chain fatty acids that have been linked to the elevation of plasma gut hormones after fat ...
Lu, Van B +2 more
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Duodenal chemosensory system: enterocytes, enteroendocrine cells, and tuft cells [PDF]
Current Opinion in Gastroenterology, 2020 Purpose of review The gut barrier serves as the primary interface between the environment and host in terms of surface area and complexity. Luminal chemosensing is a term used to describe how small molecules in the gut lumen interact with the host through surface receptors or via transport into the subepithelial space.
Akiba, Yasutada +2 more
openaire +4 more sources
PLoS Genetics, 2022 ARP/ASCL transcription factors are key determinants of cell fate specification in a wide variety of tissues, coordinating the acquisition of generic cell fates and of specific subtype identities.
A. Reuter +9 more
semanticscholar +1 more source
Review: Enteroendocrine cells: Neglected players in gastrointestinal disorders? [PDF]
Therapeutic Advances in Gastroenterology, 2008 Enteroendocrine cells (EEC) form the basis of the largest endocrine system in the body. They secrete multiple regulatory molecules which control physiological and homeostatic functions, particularly postprandial secretion and motility. Their key purpose is to act as sensors of luminal contents, either in a classical endocrine fashion, or by a ...
Moran, Gordon W. +4 more
openaire +3 more sources
Non-canonical Wnt signaling promotes directed migration of intestinal stem cells to sites of injury
Nature Communications, 2021 Stem cell migration is critical during adult tissue regeneration. Here, the authors demonstrate that enteroendocrine cells coordinate stem cell migration towards sites of injury in the Drosophila intestine by activating non-canonical Wnt signaling.
Daniel Jun-Kit Hu +3 more
doaj +1 more source
Enteroendocrine cells and appetite dysregulation in Crohn's disease [PDF]
Gut, 2011 Introduction Loss of appetite and malnutrition in active Crohn's disease (CD) are important problems. The biological mechanisms underpinning appetite loss are unclear. Enteroendocrine cells (EEC) form a pivotal part of the brain-gut axis that controls appetite and satiety.
Gordon W. Moran, John McLaughlin
openalex +3 more sources
Nutrition and L and K-enteroendocrine cells [PDF]
Current Opinion in Endocrinology, Diabetes & Obesity, 2011 The review highlights the influence of nutrients over the secretion of several hormones produced by enteroendocrine cells in the gastrointestinal tract that secrete incretin hormones. These hormones influence glucose homeostasis; food intake; gastric, pancreatic and hepatic secretions; and gastric and intestinal motility, and these aspects are ...
Ruth, Gutierrez-Aguilar +1 more
openaire +2 more sources