Results 31 to 40 of about 1,444 (144)

Detection of enterotoxigenic Bacteroides fragilis in patients with ulcerative colitis

Gut Pathogens, 2017
Purpose Ulcerative colitis (UC) as a type of inflammatory bowel disease (IBD), presumed to occur as a consequence of increased immune responses to intestinal microbiota in genetically susceptible individuals.
Samin Zamani, Sonia Hesam Shariati, Mohammad Reza Zali, Hamid Asadzadeh Aghdaei, Akram Sarabi Asiabar, Saied Bokaie, Bizhan Nomanpour, Leonardo Antonio Sechi, Mohammad Mehdi Feizabadi   +8 more
doaj   +1 more source

The interplay between tissue-resident microbiome and host proteins by integrated multi-omics during progression of colorectal adenoma to carcinoma. [PDF]

Imeta
This study integrated metagenomic and proteomic profiling of 185 colorectal tissue samples—spanning adenoma (A), tumor (T), and para‐tumor (P)—to characterize multi‐kingdom microbiome and host protein dynamics in colorectal cancer (CRC). In total, 4057 bacterial, 61 fungal, 108 archaeal, and 374 viral species were identified, revealing CRC‐specific ...
Wu D, Wang AJ, Bu DC, Sun YY, Li CH, Hong YM, Zhang S, Chen SY, Zhou JA, Zhang TY, Yu MH, Ma YJ, Wang XL, Xu J, He W, Heeschen C, Chen JF, Mao WJ, Ding H, Wu WJ, Zhao Y, Wang H, Liu NN.   +22 more
europepmc   +2 more sources

Downregulation of the farnesoid X receptor promotes colorectal tumorigenesis by facilitating enterotoxigenic Bacteroides fragilis colonization

Pharmacological Research, 2022
Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer-related deaths in the world. The downregulation of farnesoid X receptor (FXR) is frequently founded in CRC patients.
Suhang Guo, Yi Peng, Yan Lou, Lijuan Cao, Junqing Liu, Nengming Lin, Sheng Cai, Yu Kang, Su Zeng, Lushan Yu   +9 more
doaj   +1 more source

The Emerging Role of Epigenetic Modifiers in Repair of DNA Damage Associated with Chronic Inflammatory Diseases [PDF]

, 2017
At sites of chronic inflammation epithelial cells are exposed to high levels of reactive oxygen species (ROS), which can contribute to the initiation and development of many different human cancers.
Ding, Ning, Maiuri, Ashley R., O'Hagan, Heather M.   +2 more
core   +1 more source

The influence of the gut microbiota on asthma in school-aged children and adults [PDF]

, 2023
Asthma is a common respiratory disease with a highly heterogeneous pathophysiology. The human gut microbiota, comprising of all the microorganisms that inhabit the gastrointestinal tract, is linked to the development of asthma and can alter airway ...
Wilson, Naomi Grace
core   +2 more sources

The association between fecal enterotoxigenic B. fragilis with colorectal cancer

BMC Cancer, 2019
Background Enterotoxigenic Bacteroides fragilis (ETBF) is an enterotoxin-producing bacterium that possibily has a role in the occurrence and progression of colorectal cancer (CRC) by modulating the mucosal immune response and inducing epithelial cell ...
Fakhri Haghi, Elshan Goli, Bahman Mirzaei, Habib Zeighami   +3 more
doaj   +1 more source

Bacteroides fragilis Toxin Induces Cleavage and Proteasome Degradation of E-cadherin in Human Breast Cancer Cell Lines BT-474 and MCF7

Korean Journal of Clinical Laboratory Science, 2023
Enterotoxigenic Bacteroides fragilis (ETBF) has been reported to promote colitis and colon cancer through the secretion of B. fragilis toxin (BFT), a zinc-dependent metalloprotease. In colonic epithelial cells, BFT induces the cleavage of E-cadherin into
Da-Hye KANG, Sang-Hyeon YOO, Ju-Eun HONG, Ki-Jong RHEE   +3 more
doaj   +1 more source

Induction of Persistent Colitis by a Human Commensal, Enterotoxigenic Bacteroides fragilis, in Wild-Type C57BL/6 Mice [PDF]

, 2009
Enterotoxigenic Bacteroides fragilis (ETBF) causes diarrhea and is implicated in inflammatory bowel diseases and colorectal cancer. The only known ETBF virulence factor is the Bacteroides fragilis toxin (BFT), which induces E-cadherin cleavage ...
Franco, A. A., Gan, C. M., Golenbock, D., Golub, J. E., Hamad, A. R., Housseau, F., Huso, D. L., Karim, B., Mathews, L. E., Rabizadeh, S., Rhee, K.-J., Sartor, R. B., Sears, C. L., Shin, J., Wu, S., Wu, X.   +15 more
core   +2 more sources

Colonization with enterotoxigenic Bacteroides fragilis is associated with early-stage colorectal neoplasia.

PLoS ONE, 2017
BackgroundEnterotoxigenic Bacteroides fragilis (ETBF) is a toxin-producing bacteria thought to possibly promote colorectal carcinogenesis by modulating the mucosal immune response and inducing epithelial cell changes.
Rachel V Purcell, John Pearson, Alan Aitchison, Liane Dixon, Frank A Frizelle, Jacqueline I Keenan   +5 more
doaj   +1 more source

Prevalence of pks + bacteria and enterotoxigenic Bacteroides fragilis in patients with colorectal cancer

Gut Pathogens, 2022
Background Colorectal cancer (CRC) is the third most diagnosed cancer and the second most common cause of cancer deaths worldwide. CRC patients present with an increase in pathogens in their gut microbiota, such as polyketide synthase-positive bacteria ...
Manon Oliero, Roy Hajjar, Thibault Cuisiniere, Gabriela Fragoso, Annie Calvé, François Dagbert, Rasmy Loungnarath, Herawaty Sebajang, Frank Schwenter, Ramses Wassef, Richard Ratelle, Éric De Broux, Carole S. Richard, Manuela M. Santos   +13 more
doaj   +1 more source