Results 91 to 100 of about 72,632 (202)

Axonal synapse sorting in medial entorhinal cortex

Nature, 2017
Research on neuronal connectivity in the cerebral cortex has focused on the existence and strength of synapses between neurons, and their location on the cell bodies and dendrites of postsynaptic neurons. The synaptic architecture of individual presynaptic axonal trees, however, remains largely unknown.
Schmidt, H., Gour, A., Straehle, J., Boergens, K., Brecht, M., Helmstaedter, M.   +5 more
openaire   +5 more sources

Voltage-independent SK-channel dysfunction causes neuronal hyperexcitability in the hippocampus of Fmr1 knock-out mice [PDF]

, 2019
Neuronal hyperexcitability is one of the major characteristics of fragile X syndrome (FXS), yet the molecular mechanisms of this critical dysfunction remain poorly understood. Here we report a major role of voltage-independent potassium (
Carlin, Dan, Cavalli, Valeria, Deng, Pan-Yue, Klyachko, Vitaly A, Myrick, Leila K, Oh, Young Mi, Warren, Stephen T   +6 more
core   +1 more source

The medial entorhinal cortex is necessary for temporal organization of hippocampal neuronal activity. [PDF]

, 2015
The superficial layers of the medial entorhinal cortex (MEC) are a major input to the hippocampus. The high proportion of spatially modulated cells, including grid cells and border cells, in these layers suggests that MEC inputs are critical for the ...
Boublil, Brittney L, Brandon, Mark P, Cannova, Christopher C, Hales, Jena B, Leibold, Christian, Leutgeb, Jill K, Leutgeb, Stefan, Mankin, Emily A, Schlesiger, Magdalene I   +8 more
core  

Functional subregions of the human entorhinal cortex

eLife, 2015
The entorhinal cortex (EC) is the primary site of interactions between the neocortex and hippocampus. Studies in rodents and nonhuman primates suggest that EC can be divided into subregions that connect differentially with perirhinal cortex (PRC) vs parahippocampal cortex (PHC) and with hippocampal subfields along the proximo-distal axis. Here, we used
Anne Maass, David Berron, Laura A Libby, Charan Ranganath, Emrah Düzel   +4 more
openaire   +6 more sources

Partial EC outputs by degraded cues are amplified in hippocampal CA3 circuits for retrieving stored patterns

PLoS ONE, 2023
Hippocampus is known to be important for episodic memories. Measuring of hippocampal neural ensembles is therefore important for observing hippocampal cognitive processes such as pattern completion. Previous studies on pattern completion had a limitation
Kisang Eom
doaj  

Using neurite orientation dispersion and density imaging and tracts constrained by underlying anatomy to differentiate between subjects along the Alzheimer's disease continuum [PDF]

, 2019
OBJECTIVE: To assess the involvement of the white matter of the brain in the pathology of Alzheimer’s disease. Using Neurite Orientation Density and Dispersion Imaging (NODDI) and the probabilistic white matter parcellation tool Tracula as a means for ...
Zhang, Zannan
core  

Increased levels of GFAP and purinergic P2X7 receptor in Alzheimer’s disease brain are associated with Aβ, tau pathologies and synaptic loss

Alzheimer’s Research & Therapy
Astrogliosis plays an important role in Alzheimer’s disease(AD). We characterized glial fibrillary acidic protein(GFAP) and purinergic P2X7 receptor(P2X7R) alterations in AD and their associations with amyloid-β levels, tau pathology and synaptic density.
Cinzia A. Maschio, Oscar Moreno, Junlong Wang, Upasana Maheshwari, Annika Keller, Uwe Konietzko, Daniel Razansky, Agneta Nordberg, Axel Rominger, Christoph Hock, Jordi Llop, Roger M. Nitsch, Ruiqing Ni   +12 more
doaj   +1 more source

Correlation of the Changes of Gray Matter Volume with Aβ Deposition and Learning and Memory Abilities in APP/PS1 Mice at Different Periods

康复学报, 2020
Objective:To analyze the correlation in the changes of cerebral gray matter volume and the ability of memory learning, and the deposition of β-amyloid protein (Aβ) in related brain regions of Alzheimer's disease (AD) double-transgenic APP/PS1 model mice,
Yuhao ZHANG, Hao JIN, Xiufeng ZHANG, Shengxiang LIANG, Weilin LIU, Jing TAO, Lidian CHEN   +6 more
doaj  

Entorhinal grid-like codes for visual space during memory formation

Nature Communications
Eye movements, such as saccades, allow us to gather information about the environment and, in this way, can shape memory. In non-human primates, saccades are associated with the activity of grid cells in the entorhinal cortex.
Luise P. Graichen, Magdalena S. Linder, Lars Keuter, Ole Jensen, Christian F. Doeller, Claus Lamm, Tobias Staudigl, Isabella C. Wagner   +7 more
doaj   +1 more source

Quantitative investigations on the human entorhinal area [PDF]

, 1994
Bethke, B., Bohl, J., Eisenmenger, Wolfgang, Götz, M., Heinsen, H., Henn, R., Lockemann, U., Püschel, K.   +7 more
core   +1 more source