Results 61 to 70 of about 72,560 (254)

Entorhinal Cortex Thickness across the Human Lifespan [PDF]

Journal of Neuroimaging, 2015
ABSTRACTBACKGROUND AND PURPOSEHuman entorhinal cortex (ERC) connects the temporal neocortex with hippocampus and is essential for memory retrieval and navigation. Markedly, there have been only few quantitative MRI works on the ERC geometric measurements in pediatric and adult healthy subjects across the lifespan.
Khader M, Hasan, Benson, Mwangi, Bo, Cao, Zafer, Keser, Nicholas J, Tustison, Peter, Kochunov, Richard E, Frye, Mirjana, Savatic, Jair, Soares   +8 more
openaire   +2 more sources

Decoding Naturalistic Episodic Memory with Artificial Intelligence and Brain‐Machine Interface

Advanced Science, EarlyView.
Episodic memory weaves together what, where, and when of experience into a personal narrative. Cutting‐edge AI models may decode this intricate process in real‐life settings, revealing how neural activity encodes naturalistic memories. By merging AI with brain–machine interfaces, researchers are edging closer to mapping and even engineering memory ...
Dong Song
wiley   +1 more source

Mnemonic discrimination relates to perforant path integrity: An ultra-high resolution diffusion tensor imaging study. [PDF]

, 2016
Pattern separation describes the orthogonalization of similar inputs into unique, non-overlapping representations. This computational process is thought to serve memory by reducing interference and to be mediated by the dentate gyrus of the hippocampus ...
Bennett, Ilana J, Stark, Craig EL
core   +2 more sources

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Temporal Lobe and Frontal-Subcortical Dissociations in Non-Demented Parkinson's Disease with Verbal Memory Impairment.

PLoS ONE, 2015
ObjectiveThe current investigation examined verbal memory in idiopathic non-dementia Parkinson's disease and the significance of the left entorhinal cortex and left entorhinal-retrosplenial region connections (via temporal cingulum) on memory impairment ...
Jared J Tanner, Thomas H Mareci, Michael S Okun, Dawn Bowers, David J Libon, Catherine C Price   +5 more
doaj   +1 more source

Network Neurodegeneration in Alzheimer’s Disease via MRI based Shape Diffeomorphometry and High Field Atlasing

Frontiers in Bioengineering and Biotechnology, 2015
This paper examines MRI analysis of neurodegeneration in Alzheimer’s Disease (AD) in a network of structures within the medial temporal lobe using diffeomorphometry methods coupled with high-field atlasing in which the entorhinal cortex is partitioned ...
Michael I Miller, Michael I Miller, Michael I Miller, J Tilak eRatnanather, J Tilak eRatnanather, J Tilak eRatnanather, Daniel J. Tward, Daniel J. Tward, Daniel J. Tward, Timothy eBrown, David S Lee, David S Lee, Michael eKetcha, Michael eKetcha, Kanami eMori, Mei-Chang eWang, Susumu eMori, Marilyn S Albert, Laurent eYounes, Laurent eYounes, Laurent eYounes   +20 more
doaj   +1 more source

Electrophysiological Signatures of Spatial Boundaries in the Human Subiculum. [PDF]

, 2018
Environmental boundaries play a crucial role in spatial navigation and memory across a wide range of distantly related species. In rodents, boundary representations have been identified at the single-cell level in the subiculum and entorhinal cortex of ...
Aronson, Joshua P., Berry, Brent M., Das, Sandhitsu R., Davis, Kathryn A., Gorniak, Richard, Gross, Robert E., Jacobs, Joshua, Lee, Sang Ah, Lega, Bradley, Miller, Jonathan F., Rizzuto, Daniel S., Sharan, Ashwini, Sheth, Sameer, Sperling, Michael R., Stein, Joel M, Watrous, Andrew J., Worrell, Gregory A.   +16 more
core   +2 more sources

The medial entorhinal cortex keeps Up

Nature Neuroscience, 2012
A study reveals that medial entorhinal cortex layer III spiking dynamics shape the neocortical-hippocampal dialog during Up-Down state fluctuations in slow-wave sleep that may contribute to memory consolidation.
Dupret, D, Csicsvari, J
openaire   +1 more source

Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long‐Term Active Place Avoidance Memory and “Shadow” Proteins

Advanced Science, EarlyView.
Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han, Alejandro Grau‐Perales, Rayna M. Harris, Edith Lesburguères, Hsin‐Yi Kao, Asit Pal, Juan Marcos Alarcon, Todd C. Sacktor, Stefano Martiniani, Hans A. Hofmann, André A. Fenton   +10 more
wiley   +1 more source

Optimal Population Codes for Space: Grid Cells Outperform Place Cells [PDF]

, 2012
Rodents use two distinct neuronal coordinate systems to estimate their position: place fields in the hippocampus and grid fields in the entorhinal cortex.
Alexander Mathis, Andreas V. M. Herz, Barlow H., Jeffery K., Lehmann E., Martin Stemmler, O'Keefe J.   +6 more
core   +1 more source