Results 61 to 70 of about 72,632 (202)

Two Alzheimer’s disease risk genes increase entorhinal cortex volume in young adults

Frontiers in Human Neuroscience, 2014
Alzheimer’s disease (AD) risk genes alter brain structure and function decades before disease onset. Apolipoprotein E (APOE) is the strongest known genetic risk factor for Alzheimer’s disease, and a related gene, apolipoprotein J (APOJ), also affects ...
Amanda Marie Dibattista, Benson W Stevens, Benson W Stevens, G William Rebeck, Adam E. Green   +4 more
doaj   +1 more source

Effect of reward on electrophysiological signatures of grid cell population activity in human spatial navigation

Scientific Reports, 2021
The regular equilateral triangular periodic firing pattern of grid cells in the entorhinal cortex is considered a regular metric for the spatial world, and the grid-like representation correlates with hexadirectional modulation of theta (4–8 Hz) power in
Wenjing Wang, Wenxu Wang
doaj   +1 more source

Monoclonal Antibody Identification of Subpopulations of Cerebral Cortical Neurons Affected in Alzheimer disease [PDF]

, 1987
Neuronal degeneration is one of the hallmarks of Alzheimer disease (AD). Given the paucity of molecular markers available for the identification of neuronal subtypes, the specificity of neuronal loss within the cerebral cortex has been difficult to ...
Blanks, Janet C., Hinton, David R., Kozlowski, Mark, Miller, Carol A., Rudnicka, Maria   +4 more
core  

Electrophysiological Signatures of Spatial Boundaries in the Human Subiculum. [PDF]

, 2018
Environmental boundaries play a crucial role in spatial navigation and memory across a wide range of distantly related species. In rodents, boundary representations have been identified at the single-cell level in the subiculum and entorhinal cortex of ...
Aronson, Joshua P., Berry, Brent M., Das, Sandhitsu R., Davis, Kathryn A., Gorniak, Richard, Gross, Robert E., Jacobs, Joshua, Lee, Sang Ah, Lega, Bradley, Miller, Jonathan F., Rizzuto, Daniel S., Sharan, Ashwini, Sheth, Sameer, Sperling, Michael R., Stein, Joel M, Watrous, Andrew J., Worrell, Gregory A.   +16 more
core   +2 more sources

Entorhinal cortex stellate cell synchronization [PDF]

BMC Neuroscience, 2014
Theta-frequency oscillations (8-12 Hz) of large groups of synaptically coupled cells are commonly seen throughout the mammalian brain. The theta oscillations of entorhinal cortex grid cells and hippocampal place cells have received special attention recently due to their role they apparently play in the encoding of positional information. In a previous
Crotty, Patrick, Anderson, Betty K, Devine, Mary, Miettinen, Anna   +3 more
openaire   +1 more source

Reduced ictogenic potential of 4-aminopyridine in the perirhinal and entorhinal cortex of kainate-treated chronic epileptic rats

Neurobiology of Disease, 2008
We investigated the potential of 4-AP (50–100 μM) to induce seizure-like events (SLEs) in combined entorhinal cortex–hippocampal slices from Sprague Dawley rats which developed spontaneous limbic seizures following kainic acid induced status epilepticus.
Robert K. Zahn, Else A. Tolner, Christian Derst, Clemens Gruber, Rüdiger W. Veh, Uwe Heinemann   +5 more
doaj   +1 more source

Shared rhythmic subcortical GABAergic input to the entorhinal cortex and presubiculum

eLife, 2018
Rhythmic theta frequency (~5–12 Hz) oscillations coordinate neuronal synchrony and higher frequency oscillations across the cortex. Spatial navigation and context-dependent episodic memories are represented in several interconnected regions including the
Tim James Viney, Minas Salib, Abhilasha Joshi, Gunes Unal, Naomi Berry, Peter Somogyi   +5 more
doaj   +1 more source

Re-expression of CA1 and entorhinal activity patterns preserves temporal context memory at long timescales

Nature Communications, 2023
Converging, cross-species evidence indicates that memory for time is supported by hippocampal area CA1 and entorhinal cortex. However, limited evidence characterizes how these regions preserve temporal memories over long timescales (e.g., months).
Futing Zou, Guo Wanjia, Emily J. Allen, Yihan Wu, Ian Charest, Thomas Naselaris, Kendrick Kay, Brice A. Kuhl, J. Benjamin Hutchinson, Sarah DuBrow   +9 more
doaj   +1 more source

In vivo characterization of hippocampal electrophysiological processes in the heterozygous Pten knockout model of autism [PDF]

, 2018
While cognitive deficits have been described in the heterozygous Pten (+/-) KO mouse model of autism, little work has been done to demonstrate how corresponding in vitro physiological alterations in this model may underpin these cognitive deficits in ...
Barry, Jeremy, Spinella, Anthony J, Weston, Matthew   +2 more
core   +1 more source

Challenges for identifying the neural mechanisms that support spatial navigation: the impact of spatial scale. [PDF]

, 2014
Spatial navigation is a fascinating behavior that is essential for our everyday lives. It involves nearly all sensory systems, it requires numerous parallel computations, and it engages multiple memory systems.
Aginsky, Banta Lavenex, Barrash, Brandon, Burgess, Burgess, Burwell, Bush, Byrne, Cartwright, Cheng, Cheng, Cheung, Colby, Colgin, Committeri, Cushman, Derdikman, Derdikman, Doeller, Eichenbaum, Eldridge, Frank, Franz, Gheysen, Goodrich-Hunsaker, Hafting, Han, Hartley, Hölscher, Iaria, Iglói, Jacobs, Jahn, Jan M. Wiener, Janzen, Janzen, Killian, Kuipers, Kumaran, Lever, McDonald, Meilinger, Meilinger, Montello, Morris, O’Keefe, Packard, Pearce, Pengas, Poucet, Rondi-Reig, Salmon, Sato, Schendan, Schinazi, Schindler, Schölkopf, Shelton, Skaggs, Solstad, Spiers, Spiers, Steffenach, Stevens, Thomas Wolbers, Tolman, Trullier, Waller, Wang, Wang, Whitlock, Whitwell, Wiener, Wiener, Wiener, Wilton, Wolbers, Wolbers, Wolbers, Wood, Worden   +81 more
core   +2 more sources