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Consecutive entosis stages in human substrate-dependent cultured cells [PDF]
Scientific Reports, 2017 Entosis, or cell death by invading another cell, is typical for tumor epithelial cells. The formation of cell-in-cell structures is extensively studied in suspension cultures, but remains poorly understood in substrate-dependent cells.
Maria V Erokhina +2 more
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Mechanisms and consequences of entosis [PDF]
Cellular and Molecular Life Sciences, 2016 Multiple mechanisms have emerged where the engulfment of whole live cells, leading to the formation of what are called 'cell-in-cell' structures, induces cell death. Entosis is one such mechanism that drives cell-in-cell formation during carcinogenesis and development.
Michael Overholtzer
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Induction of entosis by epithelial cadherin expression [PDF]
Cell Research, 2014 Cell engulfment typically targets dead or dying cells for clearance from metazoan tissues. However, recent evidence demonstrates that live cells can also be targeted and that engulfment can cause cell death. Entosis is one mechanism proposed to mediate the engulfment and killing of live tumor cells by their neighbors, an activity often referred to as ...
Qiang Sun +2 more
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Competition between human cells by entosis [PDF]
Cell Research, 2014 Human carcinomas are comprised of complex mixtures of tumor cells that are known to compete indirectly for nutrients and growth factors. Whether tumor cells could also compete directly, for example by elimination of rivals, is not known. Here we show that human cells can directly compete by a mechanism of engulfment called entosis.
Qiang Sun, Tianzhi Luo, Oliver Florey
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Entosis, a key player in cancer cell competition [PDF]
Cell Research, 2014 Cell-in-cell structures, also referred to as 'entosis', are frequently found in human malignancies, although their prognostic impact remains to be defined. Two articles recently published in Cell Research report the stimulation of entosis by one prominent oncogene, Kras, as well as by one class of tumor suppressors, namely epithelial cadherins E and P,
Jean-Luc Perfettini, Guido Kroemer
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Entosis: aneuploidy by invasion
Nature Cell Biology, 2011Aneuploidy is one of the most prevalent phenotypes of human tumours, but the underlying cause of this phenomenon remains highly debated. Entosis, the invasion of a living cell into another cell's cytoplasm, is now shown to perturb cytokinesis and induce the formation of aneuploid cells.
Aniek Janssen
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Cancer cell cannibalism: Multiple triggers emerge for entosis
Biochimica Et Biophysica Acta - Molecular Cell Research, 2018 Entosis is a form of epithelial cell engulfment and cannibalism prevalent in human cancer. Until recently, the only known trigger for entosis was loss of attachment to the extracellular matrix, as often occurs in the tumour microenvironment. However, two new studies now reveal that entosis can also occur among adherent epithelial cells, induced by ...
J, Durgan, O, Florey
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Methods for the Study of Entosis
2013Entosis is a recently described nonapoptotic cell death mechanism that is initiated by the engulfment of live epithelial cells, leading to the formation of "cell-in-cell" structures. Entotic cell engulfment is induced by matrix detachment, and is driven by imbalances in actomyosin contraction between neighboring cells.
Qiang, Sun, Michael, Overholtzer
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Emperipolesis, entosis and beyond: Dance with fate
Cell Research, 2008Study of cell-in-cell phenomena began with the desire to understand the complex phenotype, which stemmed from Lewis' observation of non-phagocytotic process of cell-eating-cell in 1925 1. Humble et al. coined the term “emperipolesis” (from the Greek, wandering round about within) in 1950s, to define the heterogeneous cell-in-cell phenomena when they ...
Peng, Xia +3 more
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Aurora A orchestrates entosis by regulating a dynamic MCAK–TIP150 interaction [PDF]
Journal of Molecular Cell Biology, 2014 Entosis, a cell-in-cell process, has been implicated in the formation of aneuploidy associated with an aberrant cell division control. Microtubule plus-end-tracking protein TIP150 facilitates the loading of MCAK onto the microtubule plus ends and orchestrates microtubule plus-end dynamics during cell division.
Xuebiao Yao, Jinhua Zhou
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