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Entosis is a mechanism of cell-in-cell formation that resembles phagocytosis but is regulated by distinct processes related to cell-cell adhesion and actomyosin tension. Entosis results in the engulfment of cells with high levels of tension, which become internalized into cells with lower tension, following the formation of adherens junctions between ...
Jyotirekha, Das, Michael, Overholtzer
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Jyotirekha, Das, Michael, Overholtzer
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Entosis and Cell Cycle in Tumor Cell Culture
Cell and Tissue Biology, 2019Entosis is a type of cell cannibalism during which one tumor cell invades another. The fate of the inner cell can vary. It can leave the entotic vacuole, divide within it, or be subjected to lysosome-mediated degradation. The aim of our work was to determine whether MCF7 (p53+) human breast adenocarcinoma cells and A431 (p53-) human epidermoid ...
O. P. Kisurina-Evgenieva +4 more
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Stages of cell cannibalism–entosis–in normal human keratinocyte culture
Biochemistry (Moscow), 2015Entosis is a type of cell cannibalism during which one cell penetrates into another cell and usually dies inside it. Researchers mainly pay attention to initial and final stages of entosis. Besides, tumor cells in suspension are the primary object of studies.
A S, Garanina +2 more
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Entosis and Related Forms of Cell Death within Cells.
Current Molecular Medicine, 2015By eliminating the unneeded or mutant cells, programmed cell death actively participates in a wide range of biological processes from embryonic development to homeostasis maintenance in adult. Continuing efforts have identified multiple cell death pathways, with apoptosis, necrosis and autophage the mostly studied.
Y, Wang, X-D, Wang
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Entosis: Cell-in-Cell Formation that Kills Through Entotic Cell Death
Current Molecular Medicine, 2015Entosis is a cell-in-cell formation mechanism that targets viable cells for uptake in epithelial cell cultures and human tumors. Entotic cells control their own engulfment, by invading into their hosts in a Rho-GTPase and actomyosin-dependent manner. Although entotic cells are internalized while alive, most eventually undergo a non-apoptotic form of ...
O, Florey, S E, Kim, M, Overholtzer
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Molecular characterization of entosis
Caractérisation des bases moléculaires de l’entose L’entose est une forme de mort cellulaire non apoptotique caractérisée par l’internalisation d’une cellule cible vivante dans une cellule hôte vivante. Ce processus de cannibalisme cellulaire qui est également connu sous le nom de « cellule dans une cellule » est retrouvé dans de ...openaire +1 more source
Syndecan-1 Is a Key Mediator of Entosis and Cellular Competition in Pancreatic Cancer
PancreasEntosis, a form of cell-in-cell (CIC) structure formation where one cell invades and becomes internalized by another, has long been observed in various malignancies and is considered a critical cellular process in cancer progression, with potential impacts on tumor heterogeneity, survival, and metastasis. Syndecan-1 (SDC1), a transmembrane proteoglycan
Kara, Li +7 more
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Entosis implicates a new role for P53 in microcephaly pathogenesis, beyond apoptosis
BioEssaysAbstractEntosis, a form of cell cannibalism, is a newly discovered pathogenic mechanism leading to the development of small brains, termed microcephaly, in which P53 activation was found to play a major role. Microcephaly with entosis, found in Pals1 mutant mice, displays P53 activation that promotes entosis and apoptotic cell death.
Noelle A. Sterling +2 more
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Novel Methylselenoesters Induce Programed Cell Death via Entosis in Pancreatic Cancer Cells
International Journal of Molecular Sciences, 2018Núria Díaz-Argelich +2 more
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