Results 121 to 130 of about 346,423 (337)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Entropy generation in a micropolar fluid flow through an inclined channel
Alexandria Engineering Journal, 2016 In this paper the entropy generation is studied due to micropolar fluid flow through an inclined channel of parallel plates with constant pressure gradient.
D. Srinivasacharya, K. Hima Bindu
doaj +1 more source
Generalized Degree-Based Graph Entropies [PDF]
Symmetry, 2017 Inspired by the generalized entropies for graphs, a class of generalized degree-based graph entropies is proposed using the known information-theoretic measures to characterize the structure of complex networks. The new entropies depend on assigning a probability distribution about the degrees to a network.
openaire +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Case Studies in Thermal Engineering, 2018 We study the viscous nanofluid flow over a non-isothermal wedge with thermal radiation. The entropy due to irreversible processes in the system may degrade the performance of the thermodynamic system. Studying entropy generation in the flow over a porous
S.P. Goqo +4 more
doaj +1 more source
Numerical Analysis of Flow Field and Heat Transfer of 2D Wavy Ducts and Optimization by Entropy Generation Minimization Method [PDF]
, 2012 O. Nourani Zonouz, Mehdi Salmanpour
openalex +1 more source
Insight into the Dynamics of Fractional Maxwell Nano-Fluids Subject to Entropy Generation, Lorentz Force and Heat Source via Finite Difference Scheme [PDF]
, 2022 Muhammad Imran Asjad +4 more
openalex +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Investigation to define the propagation characteristics of a finite amplitude acoustic pressure wave Final report [PDF]
Aerodynamic noise generation by finite amplitude pressure wave propagation through entropy producing ...
Cottrell, J. W., Peter, A. C.
core +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source