Results 71 to 80 of about 162,974 (325)

a variational approach to niche construction [PDF]

open access: yes, 2018
In evolutionary biology, niche construction is sometimes described as a genuine evolutionary process whereby organisms, through their activities and regulatory mechanisms, modify their environment such as to steer their own evolutionary trajectory, and ...
Campbell, John   +4 more
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Improved Asymptotic Key Rate of the B92 Protocol

open access: yes, 2013
We analyze the asymptotic key rate of the single photon B92 protocol by using Renner's security analysis given in 2005. The new analysis shows that the B92 protocol can securely generate key at 6.5% depolarizing rate, while the previous analyses cannot ...
Matsumoto, Ryutaroh
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Optimization of peripheral finned-tube evaporators using entropy generation minimization

open access: yesInternational Journal of Heat and Mass Transfer, 2012
The peripheral finned-tube (PFT) is a new geometry for enhanced air-side heat transfer under moisture condensate blockage (evaporators). It consists of individual hexagonal (peripheral) fin arrangements with radial fins whose bases are attached to the tubes and tips are interconnected with the peripheral fins.
Pussoli, Bruno   +3 more
openaire   +3 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Application of the EGM Method to a LED-Based Spotlight: A Constrained Pseudo-Optimization Design Process Based on the Analysis of the Local Entropy Generation Maps

open access: yesEntropy, 2011
In this paper, the entropy generation minimization (EGM) method is applied to an industrial heat transfer problem: the forced convective cooling of a LED-based spotlight.
Enrico Sciubba, Giorgio Giangaspero
doaj   +1 more source

Analysis of Entropy Generation Minimization in Radial Heat Sink

open access: yesIndian Journal of Science and Technology, 2016
Background/Objective:In this paper, an entropy generation rateof a radial flow type heat sink model has been investigated and its minimization is the primary aim of this study to exhibit the overall performance of the model. Methods/Statistical Analysis: The entropy generation method (EGM), which is one of the best modeling and optimization approach ...
Krishna Kumar Singh, M. K. Sinha
openaire   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

Simplest random K-satisfiability problem

open access: yes, 2000
We study a simple and exactly solvable model for the generation of random satisfiability problems. These consist of $\gamma N$ random boolean constraints which are to be satisfied simultaneously by $N$ logical variables. In statistical-mechanics language,
A. Barrat   +21 more
core   +1 more source

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