Results 111 to 120 of about 528,328 (297)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
The Entropy of the Gravitational Field
, 1992 We derive a formula for the nonequilibrium entropy of a classical stochastic field in terms of correlation functions of this field. The formalism is then applied to define the entropy of gravitational perturbations (both gravitational waves and density ...
A. Guth +52 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
BiomimeticsThe extensive integration of intelligent and bionic technologies in the automotive industry has significantly heightened interest in the advancement of smart vehicle cockpits.
Liangliang Shi +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Application of Information Theoretic Measures in Neutrosophic Soft Environment [PDF]
Neutrosophic Sets and SystemsSoft set theory is a valuable mathematical tool for modeling and analyzing uncertain systems. A neutrosophic soft set is a hybrid entity of a neutrosophic set, and a soft set that enables a more comprehensive analysis of uncertainty in a system.
Surender Singh, Sonam Sharma
doaj +1 more source
Pseudo-physical measures for typical continuous maps of the interval
, 2017 We study the measure theoretic properties of typical C 0 maps of the interval. We prove that any ergodic measure is pseudo-physical, and conversely, any pseudo-physical measure is in the closure of the ergodic measures, as well as in the closure of the ...
Catsigeras, Eleonora, Troubetzkoy, Serge
core
On K-Banhatti indices and entropy measure for rhodium (III) chloride via linear regression models. [PDF]
Heliyon, 2023 Hussain M +5 more
europepmc +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source