Results 41 to 50 of about 6,410,935 (343)

LIFEGUARD proteins support plant colonization by biotrophic powdery mildew fungi [PDF]

, 2013
Pathogenic microbes manipulate eukaryotic cells during invasion and target plant proteins to achieve host susceptibility. BAX INHIBITOR-1 (BI-1) is an endoplasmic reticulum-resident cell death suppressor in plants and animals and is required for full ...
Huckelhoven, Ralph, Eichmann, Ruth, Weis, Corina   +2 more
core   +1 more source

Tolcapone Potently Inhibits Seminal Amyloid Fibrils Formation and Blocks Entry of Ebola Pseudoviruses

Frontiers in Microbiology, 2020
Ebola virus (EBOV), the causative pathogen of the deadly EBOV disease (EVD), can be transmitted via sexual transmission. Seminal amyloid fibrils have been found enhancers of EBOV infection.
Mengjie Qiu, Zhaofeng Li, Yuliu Chen, Jiayin Guo, Wei Xu, Tao Qi, Yurong Qiu, Jianxin Pang, Lin Li, Lin Li, Shuwen Liu, Suiyi Tan   +11 more
doaj   +1 more source

Survival of the fittest: positive selection of CD4+ T cells expressing a membrane-bound fusion inhibitor following HIV-1 infection [PDF]

, 2010
Although a variety of genetic strategies have been developed to inhibit HIV replication, few direct comparisons of the efficacy of these inhibitors have been carried out.
Stephen E. Braun, Berger Annemarie, John J Rossi, Stephen E Braun, Kimpel, Janine, Conolle Michelle, Annemarie Berger, R Paul Johnson, Schmitz, Jörn E., Qiu Gang, Schmitz Jörn E., Qiu, Gang, John J. Rossi, Dorothee von Laer, Wong Fay Eng, Laer, Dorothee von, Boro Dropulic, Humeau, Laurent M., Humeau Laurent M., Christian Brendel, Conolle, Michelle, Brendel Christian, Michelle Conolle, Laurent M Humeau, Braun, Stephen E., Brendel, Christian, Jörn E Schmitz, Wong, Fay Eng, Janine Kimpel, Gang Qiu, Dropulic Boro, von Laer Dorothee, Berger, Annemarie, Jörn E. Schmitz, R. Paul Johnson, Rossi, John J., Rossi John J., Laurent M. Humeau, Fay Eng Wong, Johnson, R. PauL, Kimpel Janine, Braun Stephen E., Johnson R. Paul, Dropulic, Boro   +43 more
core   +2 more sources

Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry

Viruses, 2015
Influenza A viruses (IAVs) cause seasonal pandemics and epidemics with high morbidity and mortality, which calls for effective anti-IAV agents. The glycoprotein hemagglutinin of influenza virus plays a crucial role in the initial stage of virus infection,
Wenjiao Wu, Richan Li, Xianglian Li, Jian He, Shibo Jiang, Shuwen Liu, Jie Yang   +6 more
doaj   +1 more source

Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus

Viruses, 2019
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne bunyavirus that causes severe disease in humans with case-fatality rates of up to 30%. There are currently very limited treatment options for SFTSV infection.
Shuo-Feng Yuan, J. Chan, Zi-Wei Ye, Lei Wen, T. Tsang, Jian-Li Cao, Jingjing Huang, C. Chan, K. Chik, G. K. Choi, Jian-Piao Cai, F. Yin, H. Chu, M. Liang, D. Jin, Kwok Y. Yuen   +15 more
semanticscholar   +1 more source

ING4 (inhibitor of growth family, member 4) [PDF]

, 2011
Review on ING4 (inhibitor of growth family, member 4), with data on DNA, on the protein encoded, and where the gene is ...
Miranda, C, Greco, A
core   +1 more source

Plant extracts from Cameroonian medicinal plants strongly inhibit hepatitis C virus infection in vitro

Frontiers in Microbiology, 2015
According to some recent studies, Cameroon is one of the sub-Saharan African countries most affected by hepatitis C, with low access to the standard therapy based on the combination of pegylated interferon and ribarivin.
Borris Rosnay eGalani Tietcheu, Borris Rosnay eGalani Tietcheu, Marie-Emmanuelle eSahuc, Frederic Nico eNjayou, Gaspard eDeloison, Pierre eMkounga, William eFeudjou Fouatio, Priscille eBrodin, Yves eRouille, Augustin Ephrem eNkengfack, Paul eMoundipa Fewou, Karin eSeron   +11 more
doaj   +1 more source

Development of an Effective Scalable Enantioselective Synthesis of the HIV-1 Entry Inhibitor BNM-III-170 as the Bis-Trifluoroacetate Salt

Organic Process Research & Development, 2019
We report here the development and optimization of a process synthesis for the HIV-1 entry inhibitor BNM-III-170 bis-TFA salt (1). The synthesis features a dynamic-kinetic resolution (DKR) to establish the initial stereogenicity.
Junhua Chen, Jun Park, Sharon M. Kirk, Hung-Ching Chen, Xiangqin Li, Daniel J. Lippincott, Bruno N. Melillo, Amos B. Smith   +7 more
semanticscholar   +1 more source

Autographa californica Multicapsid Nucleopolyhedrovirus efficiently infects Sf9 cells and transduces mammalian cells via direct fusion with the plasma membrane at low pH [PDF]

, 2010
The budded virus (BV) of the Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV) infects insect cells and transduces mammalian cells mainly through the endocytosis pathway.
F. Deng, M. Wang, Dong, S., Vlak, J.M., Deng, F., S. Dong, Wang, M., Qiu, Z., Z. Hu, Hu, Z.H., J. M. Vlak, H. Wang, Z. Qiu, Wang, H.L.   +13 more
core   +1 more source

Host Cell Neddylation Facilitates Alphaherpesvirus Entry in a Virus-Specific and Cell-Dependent Manner

Microbiology Spectrum, 2022
Herpes simplex virus 1 (HSV-1) commandeers the host cell proteasome at several steps of its replication cycle, including entry. Here we demonstrate that HSV-2, pseudorabies virus (PRV), and bovine herpesvirus 1 (BoHV-1) entry are blocked by bortezomib, a
Becky H. Lee, Giulia Tebaldi, Suzanne M. Pritchard, Anthony V. Nicola   +3 more
doaj   +1 more source