Results 31 to 40 of about 6,410,935 (343)

Rational Design of A Novel Small-Molecule HIV-1 Inactivator Targeting Both gp120 and gp41 of HIV-1

Frontiers in Pharmacology, 2021
Virus inactivator can inactivate cell-free virions without relying on their replication cycle, potentially reducing the impact of viral infection on cells. Previously, we successfully constructed a HIV-1 protein inactivator, 2DLT, by conjugating the D1D2
Jing Pu, Jing Pu, Yu Dai, Yu Dai, Qian Wang, Lu Lu, Junqi Zhang, Wei Xu, Lan Xie, Shengqi Wang, Fei Yu, Xiaoyang He, Shibo Jiang, Shibo Jiang   +13 more
doaj   +1 more source

Respiratory Syncytial Virus Entry Inhibitors Targeting the F Protein

Viruses, 2013
Human respiratory syncytial virus (RSV) is the main viral cause of respiratory tract infection in infants as well as some elderly and high-risk adults with chronic pulmonary disease and the severely immunocompromised.
Shibo Jiang, Lu Lu, Zhiwu Sun, Yanbin Pan   +3 more
doaj   +1 more source

Entry pathways of herpes simplex virus type 1 into human keratinocytes are dynamin- and cholesterol-dependent [PDF]

, 2011
Herpes simplex virus type 1 (HSV-1) can enter cells via endocytic pathways or direct fusion at the plasma membrane depending on the cell line and receptor(s).
Mei-Ju Hsu, Frazer J. Rixon, Petermann, P., Rixon Frazer J., Rahn, E., Hsu Mei-Ju, Knebel-Mörsdorf, D., Geraghty, R.J., Dagmar Knebel-Mörsdorf, Rahn Elena, Philipp Petermann, Knebel-Mörsdorf Dagmar, Elena Rahn, Frazer J Rixon, Hsu, M.-J., Rixon, F.J., Petermann Philipp   +16 more
core   +1 more source

Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion [PDF]

, 2004
In many cell types agonist-receptor activation leads to a rapid and transient release of Ca(2+) from intracellular stores via activation of inositol 1,4,5 trisphosphate (InsP(3)) receptors (InsP(3)Rs).
Arnoult, Christophe, Cristiano Grasso, Treves, Susan, Ronjat, Michel, Mikoshiba, Katsuhiko, ARNOULT C, GRASSO C, TREVES, Susan Nella, Ducreux, Sylvie, DUCREUX S, Smida-Rezgui, Sophia, Franzini-Armstrong, Clara, MIKOSHIBA K, SCHRUM A, Sylvie Ducreux, Susan Treves, RONJAT M, Grasso, Cristiano, Zhu, Michael X., Zorzato, Francesco, SMIDA REZGUI S, Sophia Smida-Rezgui, MOCCAGATTA L, Zhu, Michael, Francesco Zorzato, Clara Franzini-Armstrong, Christophe Arnoult, Luca Moccagatta, Schrum, Adam, Michel Ronjat, ZHU MX, GIRARD T, Girard, Thierry, Katsuhiko Mikoshiba, Thierry Girard, FRANZINI ARMSTRONG C, Moccagatta, Luca, Michael X. Zhu, Adam Schrum, Treves S, Franzini-Armstrong C, Smida-Rezgui S, Zorzato F   +42 more
core   +1 more source

Identification of a Human Respiratory Syncytial Virus Cell Entry Inhibitor by Using a Novel Lentiviral Pseudotype System

Journal of Virology, 2015
S.3065-3073Lentiviral budding is governed by group-specific antigens (Gag proteins) and proceeds in the absence of cognate viral envelope proteins, which has been exploited to create pseudotypes incorporating envelope proteins from nonlentiviral families.
S. Haid, Christina Grethe, D. Bankwitz, T. Grunwald, T. Pietschmann   +4 more
semanticscholar   +2 more sources

The rim15-Endosulfine-PP2ACdc55 signalling module regulates entry into gametogenesis and quiescence via distinct mechanisms in budding yeast [PDF]

, 2013
Quiescence and gametogenesis represent two distinct survival strategies in response to nutrient starvation in budding yeast. Precisely how environmental signals are sensed by yeast cells to trigger quiescence and gametogenesis is not fully understood.
Sourav Sarkar, Dalgaard Jacob Z., Prakash Arumugam, Arumugam P., Sarkar, Sourav, Jonathan B. A. Millar, Sarkar S., Arumugam Prakash, Millar, Jonathan B. A., Jacob Z. Dalgaard (303312), Jacob Z. Dalgaard, Arumugam, Prakash, Sourav Sarkar (430861), Millar Jonathan B. A., Jonathan B. A. Millar (430863), Sarkar Sourav, Millar J.B.A., Jonathan B A Millar, Dalgaard, Jacob Z., Jacob Z Dalgaard, Dalgaard J.Z., Prakash Arumugam (303310)   +21 more
core   +1 more source

Development of Protein- and Peptide-Based HIV Entry Inhibitors Targeting gp120 or gp41

Viruses, 2019
Application of highly active antiretroviral drugs (ARDs) effectively reduces morbidity and mortality in HIV-infected individuals. However, the emergence of multiple drug-resistant strains has led to the increased failure of ARDs, thus calling for the ...
Jing Pu, Qian Wang, Wei Xu, Lu Lu, Shibo Jiang   +4 more
doaj   +1 more source

Identification of Novel HBV/HDV Entry Inhibitors by Pharmacophore- and QSAR-Guided Virtual Screening

Viruses, 2021
The hepatic bile acid transporter Na+/taurocholate co-transporting polypeptide (NTCP) was identified in 2012 as the high-affinity hepatic receptor for the hepatitis B and D viruses (HBV/HDV).
Michael Kirstgen, Simon Franz Müller, Kira Alessandra Alicia Theresa Lowjaga, Nora Goldmann, Felix Lehmann, Sami Alakurtti, Jari Yli-Kauhaluoma, Karl-Heinz Baringhaus, Reimar Krieg, Dieter Glebe, Joachim Geyer   +10 more
doaj   +1 more source

Antiviral therapies against Ebola and other emerging viral diseases using existing medicines that block virus entry [PDF]

, 2015
Emerging viral diseases pose a threat to the global population as intervention strategies are mainly limited to basic containment due to the lack of efficacious and approved vaccines and antiviral drugs.
Temperton, Nigel J., Molesti, E, Barclay, W., Barclay, W, Wendy Barclay (686216), Eleonora Molesti, Nigel Temperton (5830610), Temperton, N, Barclay, Wendy, Edward Wright, Long, J., Molesti, E., Edward Wright (4468198), Molesti, Eleonora, Temperton, N., Long, Jason, Wright, E, Jason Long (40805), Wendy Barclay, Eleonora Molesti (686215), Wright, Edward, Wright, E., Nigel Temperton, Long, J, Jason Long   +24 more
core   +1 more source

Rational Engineering of a Sub-Picomolar HIV-1 Blocker

Viruses, 2022
With the aim of rationally devising a refined and potent HIV-1 blocker, the cDNA of CCL5 5p12 5m, an extremely potent CCR5 antagonist, was fused to that of C37, a gp41-targeted fusion inhibitor. The resulting CCL5 5p12 5m-C37 fusion protein was expressed
Massimiliano Secchi, Luca Vangelista
doaj   +1 more source