Results 11 to 20 of about 6,410,935 (343)
Control of HIV Infection In Vivo Using Gene Therapy with a Secreted Entry Inhibitor
Molecular Therapy: Nucleic Acids, 2017 HIV entry inhibitors are highly effective in controlling virus replication. We have developed a lentiviral vector that expresses a secreted entry inhibitor, soluble CD4 (sCD4), which binds to the HIV envelope glycoproteins and inactivates the virus.
Alexander Falkenhagen +6 more
doaj +2 more sources
Further Characterization of the Bifunctional HIV Entry Inhibitor sCD4-FIT45
Molecular Therapy: Nucleic Acids, 2017 HIV entry into target cells is a highly sequential and time-sensitive process. In recent years, potent HIV Env-targeting antibodies, such as VRC01, have been identified.
Alexander Falkenhagen, Sadhna Joshi
doaj +2 more sources
HTCC: Broad Range Inhibitor of Coronavirus Entry. [PDF]
PLoS ONE, 2016 To date, six human coronaviruses have been known, all of which are associated with respiratory infections in humans. With the exception of the highly pathogenic SARS and MERS coronaviruses, human coronaviruses (HCoV-NL63, HCoV-OC43, HCoV-229E, and HCoV ...
Aleksandra Milewska +8 more
doaj +2 more sources
HIV-1 Entry, Inhibitors, and Resistance [PDF]
Viruses, 2010 Entry inhibitors represent a new class of antiretroviral agents for the treatment of infection with HIV-1. While resistance to other HIV drug classes has been well described, resistance to this new class is still ill defined despite considerable clinical
Eric J. Arts +5 more
core +5 more sources
Field-Based Affinity Optimization of a Novel Azabicyclohexane Scaffold HIV-1 Entry Inhibitor
Molecules, 2019 Small-molecule HIV-1 entry inhibitors are an extremely attractive therapeutic modality. We have previously demonstrated that the entry inhibitor class can be optimized by using computational means to identify and extend the chemotypes available.
Megan E. Meuser +5 more
semanticscholar +2 more sources
A novel small-molecule inhibitor of HIV-1 entry
Drug Design, Development and Therapy, 2015 Alonso Heredia,1,3 Olga S Latinovic,2,3 Florent Barbault,4 Erik PH de Leeuw3,5 1Department of Medicine, 2Department of Microbiology and Immunology, 3Institute of Human Virology, University of Maryland Baltimore School of Medicine, Baltimore, MD, USA ...
Heredia A +3 more
doaj +1 more source
Interactions between Alcohol and the HIV Entry Inhibitor Maraviroc [PDF]
Journal of the International Association of Providers of AIDS Care, 2013 Background: Alcohol use is common among people with HIV, and beliefs about alcohol interactions with medications predict decreased medication adherence, risking drug-resistant mutations.
V. Gruber +5 more
semanticscholar +2 more sources
Cells, 2021 Current treatment options for patients infected with hepatitis B virus (HBV) are suboptimal, because the approved drugs rarely induce cure due to the persistence of the viral DNA genome in the nucleus of infected hepatocytes, and are associated with ...
Kyle E. Korolowicz +9 more
doaj +1 more source
Pharmacognosy Journal, 2022 The aim of this study is to screen the content of bioactive compounds of Moringa oleifera and to identify its potential as an antiviral against COVID 19 through an entry inhibitor mechanism using bioinformatics tools. The sample was obtained from PubChem
Nala Mawaddani +20 more
semanticscholar +1 more source