Results 41 to 50 of about 204,916 (172)

Palmitate‐Induced Primary Rat Senescent Astrocytes Exhibit Higher Inflammatory Activity and a Distinct Transcriptomic Profile Compared to Reactive Astrocytes

Journal of Neurochemistry, Volume 169, Issue 7, July 2025.
We analyzed the secretome and transcriptome of senescent and reactive cortical astrocytes. Senescent astrocytes secreted more interleukins, while gliotic astrocytes released more chemokines. Astrocytes drive neuroinflammation through both senescence and gliosis.
Michel López‐Teros, Karla Estephanía Ávila‐Galicia, Raúl Librado‐Osorio, Verónica Jimenez‐Jacinto, Jorge Antonio Garcia‐Álvarez, Georgina Hernández‐Montes, Alejandro Sanchez‐Flores, Adriana Alarcón‐Aguilar, Armando Luna‐López, Mina Königsberg   +9 more
wiley   +1 more source

Efecto de frutas y hortalizas sobre el envejecimiento celular [PDF]

, 2014
68 p.En la actualidad se vive un proceso de transición demográfica a nivel mundial, que se presenta con una baja tasa de natalidad y una baja tasa de mortalidad, lo que se traduce en un aumento de la población mayor a 60 años.
Alarcón Lozano, Marcelo (Prof. Guía), Botro Salinas, Pía   +1 more
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Early‐life and chronic exposure to high‐fat diet alters noradrenergic and glutamatergic neurotransmission in the male rat amygdala and hippocampus under cognitive challenges

Journal of Neuroscience Research, Volume 102, Issue 6, June 2024.
High‐fat diets alter amygdala and hippocampus neurochemistry in juvenile male rats. Rats with metabolic changes show enhanced odor aversion memory, linked to elevated noradrenergic and glutamatergic neurotransmission. This highlights intricate connections between obesogenic diets, neurochemistry, and cognition, implying that metabolic dysfunctions can ...
Daniel Osorio‐Gómez, Claudia I. Perez, Pamela Salcedo‐Tello, Arturo Hernández‐Matias, Susana Hernández‐Ramírez, Benjamin Arroyo, Gustavo Pacheco‐López, Ranier Gutierrez, Federico Bermúdez‐Rattoni, Kioko Guzmán‐Ramos, OBETEEN Consortium, Guillaume Ferreira, Gustavo Pacheco‐Lopez, Etienne Coutureau, Ranier Gutierrez, Pascal Barat, Federico Bermudez‐Rattoni, Gwenaelle Catheline, Claudia I. Pérez, Pauline Lafenêtre, Daniel Osorio‐Gomez, Kioko Guzman‐Ramos, Fabien Naneix, Ernesto Sanz‐Arigita, Ioannis Bakoyiannis   +24 more
wiley   +1 more source

Senescencia celular y envejecimiento

Revista Cubana de Investigaciones Biomédicas, 2003
Se realizó una revisión acerca de la senescencia celular. El envejecimiento en organismos complejos multicelulares como los mamíferos comprende cambios distintivos en células y moléculas que comprometen finalmente su adecuada funcionalidad.
Gilberto Pardo Andreu, René Delgado Hernández   +1 more
doaj  

Wnt signaling pathway improves central inhibitory synaptic transmission in a mouse model of Duchenne muscular dystrophy

Neurobiology of Disease, 2016
The dystrophin-associated glycoprotein complex (DGC) that connects the cytoskeleton, plasma membrane and the extracellular matrix has been related to the maintenance and stabilization of channels and synaptic receptors, which are both essential for ...
Marco Fuenzalida, Claudia Espinoza, Miguel Ángel Pérez, Cheril Tapia-Rojas, Loreto Cuitino, Enrique Brandan, Nibaldo C. Inestrosa   +6 more
doaj   +1 more source

Identificación de nuevas proteínas relacionadas con la resistencia a radiación ionizante y el envejecimiento celular en S. cerevisiae [PDF]

, 2023
Conclusiones: La levadura S. cerevisiae es un buen modelo biológico para estudiar los fundamentos moleculares y celulares de resistencia a radiación ionizante y su relación con el envejecimiento celular.
Alamilla Presuel, Juan Carlos
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Neuroinflammation, AD, and Dementia

, 2010
International Journal of Alzheimer’s Disease, Volume 2010, Issue 1, 2010.
Marcella Reale, Talma Brenner, Nigel H. Greig, Nibaldo Inestrosa, Diana Paleacu   +4 more
wiley   +1 more source

Biomarkers of Oxidative Stress, Inflammation, and Brain Damage in Mexican Women over 60 Years of Age with Obesity

Revista de Investigación Clínica
Background: Obesity and aging are risk factors for chronic degenerative diseases that favor neuroinflammation leading to cognitive and motor impairment. Mexico ranks second in obesity worldwide, being more prevalent in the female population.
Armando Luna-López, Julián de Jesús Lira-Rotstein, Raúl Librado-Osorio, Roberto Santín-Márquez, Óscar Rosas-Carrasco, Mina Königsberg   +5 more
doaj   +1 more source

Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEG

BMC Biology, 2020
Background Cognitive dysfunction (CD) is common among patients with the autoimmune disease systemic lupus erythematosus (SLE). Anti-ribosomal P autoantibodies associate with this dysfunction and have neuropathogenic effects that are mediated by cross ...
Sofía Espinoza, Sebastián B. Arredondo, Francisca Barake, Francisco Carvajal, Fernanda G. Guerrero, Fabian Segovia-Miranda, David M. Valenzuela, Ursula Wyneken, Alejandro Rojas-Fernández, Waldo Cerpa, Loreto Massardo, Lorena Varela-Nallar, Alfonso González   +12 more
doaj   +1 more source

Boletín Envejecimiento y Desarrollo - No.19

, 2022
El presente número del Boletín de Envejecimiento y Derechos de las Personas Mayores aborda, desde diferentes puntos de vista, la situación de los derechos humanos de las personas mayores, al tiempo que permite intercambiar experiencias y conocimientos en

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