Results 31 to 40 of about 503 (172)

Negative Modulation of Macroautophagy by Stabilized HERPUD1 is Counteracted by an Increased ER-Lysosomal Network With Impact in Drug-Induced Stress Cell Survival

Frontiers in Cell and Developmental Biology, 2022
Macroautophagy and the ubiquitin proteasome system work as an interconnected network in the maintenance of cellular homeostasis. Indeed, efficient activation of macroautophagy upon nutritional deprivation is sustained by degradation of preexisting ...
Gabriela Vargas, Omar Cortés, Eloisa Arias-Muñoz, Eloisa Arias-Muñoz, Sergio Hernández, Cristobal Cerda-Troncoso, Laura Hernández, Alexis E. González, Michael H. Tatham, Hianara A. Bustamante, Claudio Retamal, Jorge Cancino, Manuel Varas-Godoy, Ronald T. Hay, Alejandro Rojas-Fernández, Alejandro Rojas-Fernández, Viviana A. Cavieres, Viviana A. Cavieres, Patricia V. Burgos, Patricia V. Burgos, Patricia V. Burgos   +20 more
doaj   +1 more source

The Cellular Prion Protein Prevents Copper‐Induced Inhibition of P2X4 Receptors

International Journal of Alzheimer’s Disease, Volume 2011, Issue 1, 2011., 2011
Although the physiological function of the cellular prion protein (PrPC) remains unknown, several evidences support the notion of its role in copper homeostasis. PrPC binds Cu2+ through a domain composed by four to five repeats of eight amino acids. Previously, we have shown that the perfusion of this domain prevents and reverses the inhibition by Cu2+
Ramón A. Lorca, Lorena Varela-Nallar, Nibaldo C. Inestrosa, J. Pablo Huidobro-Toro, Rosanna Squitti   +4 more
wiley   +1 more source

Driving fibrosis in neuromuscular diseases: Role and regulation of Connective tissue growth factor (CCN2/CTGF)

Matrix Biology Plus, 2021
Connective tissue growth factor or cellular communication network 2 (CCN2/CTGF) is a matricellular protein member of the CCN family involved in several crucial biological processes.
Daniela L. Rebolledo, Kenneth E. Lipson, Enrique Brandan   +2 more
doaj   +1 more source

GLICACIÓN Y ENVEJECIMIENTO

Ciencia & Salud, 2018
La teoría de los radicales libre propuesta por Denham Harman en 1956 es una de las más estudiadas, postulando que el envejecimiento es el resultado de los daños causados por radicales libres en los tejidos ya que oxidan biomoléculas y conducen a muerte ...
Julio Gerardo Mora Campos
doaj   +1 more source

Unveiling the Proteomic Landscape of Extracellular Vesicles: Implications for Neurodegeneration and Neuroprotection

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
Extracellular vesicles (EVs) are tiny, membrane‐covered packets that cells naturally release to send molecular information to one another. In the brain, they function as couriers that move proteins, lipids, and other signals between neurons, glial cells, and the blood–brain barrier.
Berenice N. Bernal‐Vicente, Isaac Ponce, Emmanuel Ríos‐Castro, Perla Moreno‐Castilla, Luis B. Tovar‐y‐Romo   +4 more
wiley   +1 more source

Activos antioxidantes en la formulación de productos cosméticos antienvejecimiento

Ars Pharmaceutica
Objetivos: El conocimiento acerca de los mecanismos subyacentes al envejecimiento de la piel es, en la actualidad, una estrategia clave en la prevención de sus manifestaciones cutáneas.
Celia Castaño Amores, Pablo José Hernández Benavides   +1 more
doaj   +1 more source

Wnt signaling pathway improves central inhibitory synaptic transmission in a mouse model of Duchenne muscular dystrophy

Neurobiology of Disease, 2016
The dystrophin-associated glycoprotein complex (DGC) that connects the cytoskeleton, plasma membrane and the extracellular matrix has been related to the maintenance and stabilization of channels and synaptic receptors, which are both essential for ...
Marco Fuenzalida, Claudia Espinoza, Miguel Ángel Pérez, Cheril Tapia-Rojas, Loreto Cuitino, Enrique Brandan, Nibaldo C. Inestrosa   +6 more
doaj   +1 more source

Neuronopathic Gaucher disease: Beyond lysosomal dysfunction

Frontiers in Molecular Neuroscience, 2022
Gaucher disease (GD) is an inherited disorder caused by recessive mutations in the GBA1 gene that encodes the lysosomal enzyme β-glucocerebrosidase (β-GC).
Nohela B. Arévalo, Nohela B. Arévalo, Nohela B. Arévalo, Cristian M. Lamaizon, Cristian M. Lamaizon, Viviana A. Cavieres, Viviana A. Cavieres, Patricia V. Burgos, Patricia V. Burgos, Patricia V. Burgos, Alejandra R. Álvarez, Alejandra R. Álvarez, Alejandra R. Álvarez, María J. Yañez, Silvana Zanlungo   +14 more
doaj   +1 more source

Ecm29-Dependent Proteasome Localization Regulates Cytoskeleton Remodeling at the Immune Synapse

Frontiers in Cell and Developmental Biology, 2021
The formation of an immune synapse (IS) enables B cells to capture membrane-tethered antigens, where cortical actin cytoskeleton remodeling regulates cell spreading and depletion of F-actin at the centrosome promotes the recruitment of lysosomes to ...
Jorge Ibañez-Vega, Felipe Del Valle, Juan José Sáez, Fanny Guzman, Jheimmy Diaz, Andrea Soza, Andrea Soza, María Isabel Yuseff   +7 more
doaj   +1 more source

Palmitate‐Induced Primary Rat Senescent Astrocytes Exhibit Higher Inflammatory Activity and a Distinct Transcriptomic Profile Compared to Reactive Astrocytes

Journal of Neurochemistry, Volume 169, Issue 7, July 2025.
We analyzed the secretome and transcriptome of senescent and reactive cortical astrocytes. Senescent astrocytes secreted more interleukins, while gliotic astrocytes released more chemokines. Astrocytes drive neuroinflammation through both senescence and gliosis.
Michel López‐Teros, Karla Estephanía Ávila‐Galicia, Raúl Librado‐Osorio, Verónica Jimenez‐Jacinto, Jorge Antonio Garcia‐Álvarez, Georgina Hernández‐Montes, Alejandro Sanchez‐Flores, Adriana Alarcón‐Aguilar, Armando Luna‐López, Mina Königsberg   +9 more
wiley   +1 more source