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Emerging Synaptic Molecules as Candidates in the Etiology of Neurological Disorders

Neural Plasticity, 2017
Synapses are complex structures that allow communication between neurons in the central nervous system. Studies conducted in vertebrate and invertebrate models have contributed to the knowledge of the function of synaptic proteins. The functional synapse
Viviana I. Torres, Daniela Vallejo, Nibaldo C. Inestrosa +2 more
doaj +2 more sources

Andrographolide Stimulates Neurogenesis in the Adult Hippocampus

Neural Plasticity, 2015
Andrographolide (ANDRO) is a labdane diterpenoid component of Andrographis paniculata widely used for its anti-inflammatory properties. We have recently determined that ANDRO is a competitive inhibitor of glycogen synthase kinase-3β (GSK-3β), a key ...
Lorena Varela-Nallar +4 more
doaj +2 more sources

Envejecimiento fotoenvejecimiento [PDF]

Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica, 1999
Se define como envejecimiento la pérdida progresiva de todas las funciones del organismo, haciéndolo más vulnerable a los factores ambientales externos, hecho que en biología se conoce como entropía celular.
María Mélida Durán
doaj +2 more sources

CIBERER: Spanish national network for research on rare diseases: A highly productive collaborative initiative

Clinical Genetics, Volume 101, Issue 5-6, Page 481-493, May-June 2022., 2022
Abstract CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in ...
Juan Luque +371 more
wiley +1 more source

The linkage between inflammation and fibrosis in muscular dystrophies: The axis autotaxin–lysophosphatidic acid as a new therapeutic target?

Journal of Cell Communication and Signaling, Volume 15, Issue 3, Page 317-334, September 2021., 2021
Abstract Muscular dystrophies (MDs) are a diverse group of severe disorders characterized by increased skeletal muscle feebleness. In many cases, respiratory and cardiac muscles are also compromised. Skeletal muscle inflammation and fibrosis are hallmarks of several skeletal muscle diseases, including MDs. Until now, several keys signaling pathways and
Felipe S. Gallardo +2 more
wiley +1 more source

Metformin and tBHQ Treatment Combined with an Exercise Regime Prevents Osteosarcopenic Obesity in Middle‐Aged Wistar Female Rats

Oxidative Medicine and Cellular Longevity, Volume 2021, Issue 1, 2021., 2021
Osteosarcopenic obesity (OSO) is characterized by bone density, mass, and muscle strength loss, in conjunction with adipose tissue increase. OSO impairs physical activity and mobility, provoking autonomy loss; also, it is known that augmenting body fat in the elderly decreases life expectancy.
Rafael Toledo-Pérez +9 more
wiley +1 more source

Low‐Intensity Exercise Routine for a Long Period of Time Prevents Osteosarcopenic Obesity in Sedentary Old Female Rats, by Decreasing Inflammation and Oxidative Stress and Increasing GDF‐11

Oxidative Medicine and Cellular Longevity, Volume 2021, Issue 1, 2021., 2021
The loss of skeletal muscle mass and strength is known as sarcopenia; it is characterized as a progressive and generalized muscle disorder associated with aging. This deterioration can seriously compromise the elderly’s health and reduce their quality of life.
Beatriz Mena-Montes +12 more
wiley +1 more source

Enhanced Activity of Exportin‐1/CRM1 in Neurons Contributes to Autophagy Dysfunction and Senescent Features in Old Mouse Brain

Oxidative Medicine and Cellular Longevity, Volume 2021, Issue 1, 2021., 2021
Brain aging is characterized by dysfunctional autophagy and cellular senescence, among other features. While autophagy can either promote or suppress cellular senescence in proliferating cells, in postmitotic cells, such as neurons, autophagy impairment promotes cellular senescence.
Elisa Gorostieta-Salas +6 more
wiley +1 more source

Transcriptomic signatures and network-based methods uncover new senescent cell anti-apoptotic pathways and senolytics. [PDF]

FEBS J
This study identifies new senescent cell antiapoptotic pathways (SCAPs) by analyzing transcriptomic signatures and co‐expression networks. We uncover novel antiapoptotic pathways, called SCAPs, and propose potential senolytic drugs, including Fluorouracil, which targets key SCAPs.
Olascoaga S +6 more
europepmc +2 more sources

Sonic hedgehog is basolaterally sorted from the TGN and transcytosed to the apical domain involving Dispatched-1 at Rab11-ARE

Frontiers in Cell and Developmental Biology, 2022
Hedgehog proteins (Hhs) secretion from apical and/or basolateral domains occurs in different epithelial cells impacting development and tissue homeostasis.
Lisette Sandoval +9 more
doaj +1 more source

wnt signaling
envejecimiento
estrés oxidativo

autophagy
alzheimer’s disease
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biological psychiatry
neurosciences
oxidative stress