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Envejecimiento Celular - Alzheimer

Odontología Sanmarquina, 2005
Históricamente, El término enfermedad de Alzheimer se usó si el padecimiento empezaba antes de los 65 años de edad, y demencia senil si lo hacía después.
Luis Cuadrao Zavalela
doaj   +3 more sources

Senescencia celular y envejecimiento

Revista Cubana de Investigaciones Biomédicas, 2003
Se realizó una revisión acerca de la senescencia celular. El envejecimiento en organismos complejos multicelulares como los mamíferos comprende cambios distintivos en células y moléculas que comprometen finalmente su adecuada funcionalidad.
Gilberto Pardo Andreu, René Delgado Hernández   +1 more
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Cambios morfológicos, celulares y moleculares en la fibrosis renal debido al envejecimiento

Anales de la Facultad de Medicina, 2015
En los últimos 50 años se ha registrado un aumento gradual de la tasa de envejecimiento de la población uruguaya, reflejándose en un incremento de pacientes con enfermedad renal crónica mayores de 65 años. Este fenómeno plantea la interrogante de cómo el
Miguel Alaga, Paola Carzoglio, Rodrigo Décima, Ramiro Funes, Cecilia Spiess, Mercedes Rodríguez-Teja   +5 more
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Regulation of Phosphorylated State of NMDA Receptor by STEP₆₁ Phosphatase after Mild-Traumatic Brain Injury: Role of Oxidative Stress

Antioxidants, 2021
Traumatic Brain Injury (TBI) mediates neuronal death through several events involving many molecular pathways, including the glutamate-mediated excitotoxicity for excessive stimulation of N-methyl-D-aspartate receptors (NMDARs), producing activation of ...
Francisco J. Carvajal, Waldo Cerpa
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Metformin and tBHQ Treatment Combined with an Exercise Regime Prevents Osteosarcopenic Obesity in Middle‐Aged Wistar Female Rats

Oxidative Medicine and Cellular Longevity, Volume 2021, Issue 1, 2021., 2021
Osteosarcopenic obesity (OSO) is characterized by bone density, mass, and muscle strength loss, in conjunction with adipose tissue increase. OSO impairs physical activity and mobility, provoking autonomy loss; also, it is known that augmenting body fat in the elderly decreases life expectancy.
Rafael Toledo-Pérez, Stefanie Paola Lopéz-Cervantes, David Hernández-Álvarez, Beatriz Mena-Montes, Gibran Pedraza-Vázquez, Carlos Sánchez-Garibay, Norma Edith López-Diazguerrero, Mina Königsberg, Armando Luna-López, Adrian Sturza   +9 more
wiley   +1 more source

Low‐Intensity Exercise Routine for a Long Period of Time Prevents Osteosarcopenic Obesity in Sedentary Old Female Rats, by Decreasing Inflammation and Oxidative Stress and Increasing GDF‐11

Oxidative Medicine and Cellular Longevity, Volume 2021, Issue 1, 2021., 2021
The loss of skeletal muscle mass and strength is known as sarcopenia; it is characterized as a progressive and generalized muscle disorder associated with aging. This deterioration can seriously compromise the elderly’s health and reduce their quality of life.
Beatriz Mena-Montes, David Hernández-Álvarez, Gibrán Pedraza-Vázquez, Rafael Toledo-Pérez, Raúl Librado-Osorio, Jorge Antonio García-Álvarez, Adriana Alarcón-Aguilar, Roberto Lazzarini-Lechuga, Oscar Rosas-Carrasco, Mina Königsberg, Norma Edith López-Diazguerrero, Armando Luna-López, Luciana Mosca   +12 more
wiley   +1 more source

Wnt5a promotes hippocampal postsynaptic development and GluN2B-induced expression via the eIF2α HRI kinase

Scientific Reports, 2021
Wnt signaling plays a key role in neurodevelopment and neuronal maturation. Specifically, Wnt5a stimulates postsynaptic assemblies, increases glutamatergic neurotransmission and, through calcium signaling, generates nitric oxide (NO).
Eva Ramos-Fernández, Macarena S. Arrázola, Carolina A. Oliva, Sebastián B. Arredondo, Lorena Varela-Nallar, Nibaldo C. Inestrosa   +5 more
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Enhanced Activity of Exportin‐1/CRM1 in Neurons Contributes to Autophagy Dysfunction and Senescent Features in Old Mouse Brain

Oxidative Medicine and Cellular Longevity, Volume 2021, Issue 1, 2021., 2021
Brain aging is characterized by dysfunctional autophagy and cellular senescence, among other features. While autophagy can either promote or suppress cellular senescence in proliferating cells, in postmitotic cells, such as neurons, autophagy impairment promotes cellular senescence.
Elisa Gorostieta-Salas, Daniel Moreno-Blas, Cristian Gerónimo-Olvera, Bulmaro Cisneros, Felipe A. Court, Susana Castro-Obregón, Jan Gebicki   +6 more
wiley   +1 more source

Adiponectin and resistin modulate the progression of Alzheimer´s disease in a metabolic syndrome model

Frontiers in Endocrinology, 2023
Metabolic syndrome (MetS), a cluster of metabolic conditions that include obesity, hyperlipidemia, and insulin resistance, increases the risk of several aging-related brain diseases, including Alzheimer’s disease (AD).
Pedro Cisternas, Camila Gherardelli, Joel Gutierrez, Paulina Salazar, Carolina Mendez-Orellana, G. William Wong, G. William Wong, Nibaldo C. Inestrosa, Nibaldo C. Inestrosa   +8 more
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Müller Glia to Müller Glia Extracellular Vesicle-Dependent Signaling Induces Multipotency Genes and l Expression in Response to N-methyl-D-aspartate (NMDA) Exposure

ASN Neuro, 2023
A strict localization into the neural retina and the capacity to survive many pathogenic conditions are unique characteristics of Müller glia. Retinal damage induces cellular and molecular changes that place Müller cells as focal points to either protect
Ana Karen Carapia, Erick J. Martinez-Colin, Deisy Segura-Villalobos, Rebeca Yael Victoria-Chavez, Ivonne Lezama, Eduardo Martinez-Martinez, Monica Lamas   +6 more
doaj   +1 more source