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Emerging Synaptic Molecules as Candidates in the Etiology of Neurological Disorders

Neural Plasticity, 2017
Synapses are complex structures that allow communication between neurons in the central nervous system. Studies conducted in vertebrate and invertebrate models have contributed to the knowledge of the function of synaptic proteins. The functional synapse
Viviana I. Torres, Daniela Vallejo, Nibaldo C. Inestrosa +2 more
doaj +2 more sources

Andrographolide Stimulates Neurogenesis in the Adult Hippocampus

Neural Plasticity, 2015
Andrographolide (ANDRO) is a labdane diterpenoid component of Andrographis paniculata widely used for its anti-inflammatory properties. We have recently determined that ANDRO is a competitive inhibitor of glycogen synthase kinase-3β (GSK-3β), a key ...
Lorena Varela-Nallar +4 more
doaj +2 more sources

Transcriptomic signatures and network-based methods uncover new senescent cell anti-apoptotic pathways and senolytics. [PDF]

FEBS J
This study identifies new senescent cell antiapoptotic pathways (SCAPs) by analyzing transcriptomic signatures and co‐expression networks. We uncover novel antiapoptotic pathways, called SCAPs, and propose potential senolytic drugs, including Fluorouracil, which targets key SCAPs.
Olascoaga S +6 more
europepmc +2 more sources

Tet3-mediated DNA demethylation is essential for maintaining the dedifferentiation capacity of mammalian Müller glia [PDF]

Frontiers in Molecular Neuroscience
Müller glia (MG) are retinal resident cells with diverse functions, including reprograming and regeneration in certain species. While the mammalian retina possesses molecular mechanisms for MG dedifferentiation and neuronal differentiation, it fails to ...
Erick J. Martinez-Colin +7 more
doaj +2 more sources

Capsaicin: beyond TRPV1 [PDF]

Frontiers in Nutrition
Capsaicin, the chili-pungent compound, has a peculiar chemical structure that allows it to impact mammalian physiology. Besides its classical effects through activating the Transient Receptor Potential Vanilloid type 1 (TRPV1), growing experimental ...
Rebeca Juárez-Contreras +11 more
doaj +2 more sources

The core genetic drivers of chronological aging in yeast are universal regulators of longevity [PDF]

Microbial Cell
The chronological lifespan of Saccharomyces cerevisiae has significantly contributed to our understanding of aging in eukaryotic cells. However, gaining a genome-wide perspective of this trait remains challenging due to substantial discrepancies observed
Erika Cruz-Bonilla +4 more
doaj +2 more sources

Morphological neurite changes induced by porcupine inhibition are rescued by Wnt ligands

Cell Communication and Signaling, 2021
Background Wnt signaling plays key roles in cellular and physiological processes, including cell proliferation, differentiation and migration during development and tissue homeostasis in adults. This pathway can be defined as Wnt/β-catenin-dependent or β-
Juan A. Godoy +2 more
doaj +1 more source

Disruption of Glucose Metabolism in Aged Octodon degus: A Sporadic Model of Alzheimer's Disease

Frontiers in Integrative Neuroscience, 2021
Alzheimer's disease is a progressive neurodegenerative disorder and the most common cause of dementia. Although transgenic Alzheimer's disease (AD) animal models have greatly contributed to our understanding of the disease, therapies tested in these ...
Pedro Cisternas +4 more
doaj +1 more source

CIBERER: Spanish national network for research on rare diseases: A highly productive collaborative initiative

Clinical Genetics, Volume 101, Issue 5-6, Page 481-493, May-June 2022., 2022
Abstract CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in ...
Juan Luque +371 more
wiley +1 more source

The linkage between inflammation and fibrosis in muscular dystrophies: The axis autotaxin–lysophosphatidic acid as a new therapeutic target?

Journal of Cell Communication and Signaling, Volume 15, Issue 3, Page 317-334, September 2021., 2021
Abstract Muscular dystrophies (MDs) are a diverse group of severe disorders characterized by increased skeletal muscle feebleness. In many cases, respiratory and cardiac muscles are also compromised. Skeletal muscle inflammation and fibrosis are hallmarks of several skeletal muscle diseases, including MDs. Until now, several keys signaling pathways and
Felipe S. Gallardo +2 more
wiley +1 more source

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