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Tet3-mediated DNA demethylation is essential for maintaining the dedifferentiation capacity of mammalian Müller glia [PDF]
Frontiers in Molecular NeuroscienceMüller glia (MG) are retinal resident cells with diverse functions, including reprograming and regeneration in certain species. While the mammalian retina possesses molecular mechanisms for MG dedifferentiation and neuronal differentiation, it fails to ...
Erick J. Martinez-Colin +7 more
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Frontiers in NutritionCapsaicin, the chili-pungent compound, has a peculiar chemical structure that allows it to impact mammalian physiology. Besides its classical effects through activating the Transient Receptor Potential Vanilloid type 1 (TRPV1), growing experimental ...
Rebeca Juárez-Contreras +11 more
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The core genetic drivers of chronological aging in yeast are universal regulators of longevity [PDF]
Microbial CellThe chronological lifespan of Saccharomyces cerevisiae has significantly contributed to our understanding of aging in eukaryotic cells. However, gaining a genome-wide perspective of this trait remains challenging due to substantial discrepancies observed
Erika Cruz-Bonilla +4 more
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Morphological neurite changes induced by porcupine inhibition are rescued by Wnt ligands
Cell Communication and Signaling, 2021 Background Wnt signaling plays key roles in cellular and physiological processes, including cell proliferation, differentiation and migration during development and tissue homeostasis in adults. This pathway can be defined as Wnt/β-catenin-dependent or β-
Juan A. Godoy +2 more
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Disruption of Glucose Metabolism in Aged Octodon degus: A Sporadic Model of Alzheimer's Disease
Frontiers in Integrative Neuroscience, 2021 Alzheimer's disease is a progressive neurodegenerative disorder and the most common cause of dementia. Although transgenic Alzheimer's disease (AD) animal models have greatly contributed to our understanding of the disease, therapies tested in these ...
Pedro Cisternas +4 more
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Antioxidants, 2021 Traumatic Brain Injury (TBI) mediates neuronal death through several events involving many molecular pathways, including the glutamate-mediated excitotoxicity for excessive stimulation of N-methyl-D-aspartate receptors (NMDARs), producing activation of ...
Francisco J. Carvajal, Waldo Cerpa
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Scientific Reports, 2021 Wnt signaling plays a key role in neurodevelopment and neuronal maturation. Specifically, Wnt5a stimulates postsynaptic assemblies, increases glutamatergic neurotransmission and, through calcium signaling, generates nitric oxide (NO).
Eva Ramos-Fernández +5 more
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Frontiers in Endocrinology, 2023 Metabolic syndrome (MetS), a cluster of metabolic conditions that include obesity, hyperlipidemia, and insulin resistance, increases the risk of several aging-related brain diseases, including Alzheimer’s disease (AD).
Pedro Cisternas +8 more
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ASN Neuro, 2023 A strict localization into the neural retina and the capacity to survive many pathogenic conditions are unique characteristics of Müller glia. Retinal damage induces cellular and molecular changes that place Müller cells as focal points to either protect
Ana Karen Carapia +6 more
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Hormetic-Like Effects of L-Homocysteine on Synaptic Structure, Function, and Aβ Aggregation
Pharmaceuticals, 2020 Alzheimer’s Disease (AD) is the primary cause of dementia among the elderly population. Elevated plasma levels of homocysteine (HCy), an amino acid derived from methionine metabolism, are considered a risk factor and biomarker of AD and other types
Carla Montecinos-Oliva +4 more
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