Results 41 to 50 of about 20,169 (257)

Tranexamic acid is associated with post‐injury mortality in a resource‐limited trauma system: Findings from the epidemiology and outcomes of prolonged trauma care cohort study

Transfusion, EarlyView.
Abstract Background Injury‐related deaths claim millions of lives annually, with severe hemorrhage a leading cause. This study assesses tranexamic acid (TXA) administered within 3 h post‐injury on mortality in trauma patients. Study Design And Methods We conducted secondary database analysis of EpiC, a multicenter, prospective cohort of trauma patients
Adane F. Wogu, Julia M. Dixon, Mengli Xiao, Hendrick J. Lategan, George Oosthuizen, Steven G. Schauer, Elmin Steyn, Smitha Bhaumik, Janette Verster, Craig Wylie, Shaheem de Vries, Mohammad Mayet, Lesley Hodsdon, Leigh Wagner, L' Oreal Snyders, Karlien Doubell, Denise Lourens, Willem Stassen, Christiaan Rees, Jessica Young, Ernest E. Moore, Nee‐Kofi Mould‐Millman   +21 more
wiley   +1 more source

Cerebrovascular Accident and Snake Envenomation: A Scoping Study

International Journal of Clinical Research & Trials, 2019
Background: Snake envenomation is associated with serious complications including infections, bleeding and, in rare occasions, thrombosis. Previous work by our group examined the association of snakebite and acute myocardial infarction.
Mohammed Al-sadawi, Maliheh Mohamadpour, Angelina Zhyvotovska, T. Ahmad, J. Schechter, Y. Soliman, Samy I McFarlane   +6 more
semanticscholar   +1 more source

Envenomation by the Malagasy colubrid snake Langaha madagascariensis

Journal of Venomous Animals and Toxins including Tropical Diseases, 2008
This report documents a case of envenomation by a Malagasy opisthoglyphous snake, Langaha madagascariensis. The snake bit the finger of a healthy adult man who was attempting to record its morphological measurements as part of a biodiversity survey which
NC D'Cruze
doaj   +1 more source

Analysis of Centruroides (Scorpion) Immune F(ab’)2 (Equine) administration by slow intravenous push

Toxicology Communications, 2023
Scorpion envenomation is a common emergency department presentation in Arizona and antivenom is often administered . This study evaluates the safety of Centruroides (Scorpion) Immune F(ab’)2 (Equine) administered as a single-vial-serial dosing strategy ...
Clinton Peter, Spencer Kruggel, Aimee Mishler, Bikash Bhattarai, Dan Quan   +4 more
doaj   +1 more source

Clinical manifestations of Florida spot keratopathy in dogs and cats: One hundred cases (2021–2024)

Veterinary Ophthalmology, EarlyView.
Abstract Purpose This study describes the ocular findings in dogs and cats diagnosed with Florida spot keratopathy (FSK) at a single institution. Methods Affected animals underwent a single comprehensive ophthalmic examination, with no follow‐ups conducted. Data on patient demographics and clinical findings were collected and analyzed. Results Based on
O. Pe'er, K. W. Handel, D. Arad, L. Sebbag, R. Ofri   +4 more
wiley   +1 more source

Early administration of Fab antivenom resulted in faster limb recovery in copperhead snake envenomation patients

Clinical toxicology, 2018
Background: No previous research has studied whether early snake antivenom administration leads to better clinical outcomes than late antivenom administration in North American pit viper envenomation. Methods: A secondary analysis of data from a clinical
V. Anderson, Charles J. Gerardo, M. Rapp-Olsson, Sean P. Bush, Michael E. Mullins, S. Greene, Eric A. Toschlog, Eugenia B. Quackenbush, S. Rutherfoord Rose, Richard B. Schwartz, Nathan P. Charlton, Brandon J. Lewis, Kurt C. Kleinschmidt, K. Sharma, E. Lavonas   +14 more
semanticscholar   +1 more source

Repeat antivenom administration following crotalidae immune F(ab’)2 antivenom in Agkistrodon species: a case series

Toxicology Communications, 2023
Crotalidae immune F(ab’)2 [equine] was approved for the treatment of North American rattlesnake envenomation in 2015 and Agkistrodon envenomation in 2021 after a phase 3 trial demonstrated lower rates of late hemotoxicity compared to crotalidae ...
Erin Ryan, Sukhshant Atti, Stacy Marshall, Jessica Rivera, William Rushton   +4 more
doaj   +1 more source

Early cardiovascular collapse after envenoming by snakes in Australia, 2005–2020: an observational study (ASP‐31)

Medical Journal of Australia, Volume 222, Issue 6, Page 313-317, April 2025.
Abstract Objectives To investigate the frequency, timing, and characteristics of cardiovascular collapse after snakebite in Australia, and the complications of collapse following envenoming. Study design Observational study; analysis of prospectively collected demographic and clinical data.
Geoffrey K Isbister, Katherine Z Isoardi, Angela L Chiew, Shane Jenkins, Nicholas A Buckley   +4 more
wiley   +1 more source

Exploration of the Inhibitory Potential of Varespladib for Snakebite Envenomation

Molecules, 2018
Phospholipase A2s (PLA2) is a major component of snake venom with diverse pathologic toxicities and, therefore, a potential target for antivenom therapy. Varespladib was initially designed as an inhibitor of mammal PLA2s, and was recently repurposed to a
Yiding Wang, Jing Zhang, Denghong Zhang, Huixiang Xiao, Shengwei Xiong, Chunhong Huang   +5 more
semanticscholar   +1 more source

Evaluating Antivenom Efficacy against Echis carinatus Venoms—Screening for In Vitro Alternatives

Toxins, 2022
In India, polyvalent antivenom is the mainstay treatment for snakebite envenoming. Due to batch-to-batch variation in antivenom production, manufacturers have to estimate its efficacy at each stage of IgG purification using the median effective dose ...
Siddharth Bhatia, Avni Blotra, Karthikeyan Vasudevan   +2 more
doaj   +1 more source