Results 41 to 50 of about 5,373,729 (260)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Environmental and wider economic implications of modifications to environmental tax reform [PDF]

, 2002
The most common definition of Environmental Tax Reform (ETR) is the use of the revenue from environmental taxes to reduce distortionary labour taxes. However, the PETRAS project has shown that there are a number of social and political impediments to ...
Clinch, J. Peter, Dunne, Louise
core   +1 more source

Necrotizing fasciitis: review, recent concepts in etiopathogeny and diagnosis

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2018
Necrotizing fasciitis is part of the necrotizing infections of the soft tissues. It is a rare, but life-threatening condition, with different clinical manifestations and germs that progress in a similar way.
Héctor Gabriel Díaz-Carrillo, William Álvarez-Consuegra, Runiel Tamayo-Pérez   +2 more
doaj  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Cell surface membrane proteins as personalized biomarkers: where we stand and where we are headed [PDF]

, 2013
Personalized medicine requires the development of a wide array of biomarker diagnostic assays, reflecting individual variations and thus allowing tailored therapeutic interventions.
Szabó, Edit, Sarkadi, Balázs, Várady, György, Németh, Adrienn, Cserepes, Judit   +4 more
core   +1 more source

Risk assessment for colorectal cancer via polygenic risk score and lifestyle exposure: a large-scale association study of East Asian and European populations

Genome Medicine, 2023
Background The genetic architectures of colorectal cancer are distinct across different populations. To date, the majority of polygenic risk scores (PRSs) are derived from European (EUR) populations, which limits their accurate extrapolation to other ...
Junyi Xin, Mulong Du, Dongying Gu, Kewei Jiang, Mengyun Wang, Mingjuan Jin, Yeting Hu, Shuai Ben, Silu Chen, Wei Shao, Shuwei Li, Haiyan Chu, Linjun Zhu, Chen Li, Kun Chen, Kefeng Ding, Zhengdong Zhang, Hongbing Shen, Meilin Wang   +18 more
doaj   +1 more source

Construction, evaluation, and AOP framework-based application of the EpPRS as a genetic surrogate for assessing environmental pollutants

Environment International, 2023
Background: Environmental pollutant measurement is essential for accurate health risk assessment. However, the detection of humans’ internal exposure to pollutants is cost-intensive and consumes time and energy.
Silu Chen, Junyi Xin, Zhutao Ding, Lingyan Zhao, Shuai Ben, Rui Zheng, Shuwei Li, Huiqin Li, Wei Shao, Yifei Cheng, Zhengdong Zhang, Mulong Du, Meilin Wang   +12 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Seasonal Variation in Bivalve Antioxidant Enzymes: Can they be used as indicators of heavy metal contamination? [PDF]

, 2009
Seasonal variations in the activity of several enzymes (glutathione reductase (GR), glutathione S-transferase (GST), and glutathione peroxidase (GPx)) involved in the glutathione cellular defence system were measured in whole tissues of the common New ...
Gibson, Aimee Clare
core  

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source