Results 21 to 30 of about 5,373,729 (260)

A universal in silico V(D)J recombination strategy for developing humanized monoclonal antibodies

Journal of Nanobiotechnology, 2022
Background Humanization of mouse monoclonal antibodies (mAbs) is crucial for reducing their immunogenicity in humans. However, humanized mAbs often lose their binding affinities.
Yuan-Chin Hsieh, Jun-min Liao, Kuo-Hsiang Chuang, Kai-Wen Ho, Shih-Ting Hong, Hui-Ju Liu, Bo-Cheng Huang, I-Ju Chen, Yen-Ling Liu, Jaw-Yuan Wang, Hsiang-Lin Tsai, Yu-Cheng Su, Yen-Tseng Wang, Tian-Lu Cheng   +13 more
doaj   +1 more source

Sodium 4-Carboxymethoxyimino-(4-HPR) a Novel Water-Soluble Derivative of 4-Oxo-4-HPR Endowed with In Vivo Anticancer Activity on Solid Tumors

Frontiers in Pharmacology, 2017
4-oxo-N-(4-hydroxyphenyl)retinamide (4-oxo-4-HPR), an active polar metabolite of the synthetic retinoid N-(4-hydroxyphenyl)retinamide (4-HPR), was shown to exert promising antitumor activity through at least two independent mechanisms of action ...
Valentina Appierto, Paola Tiberio, Elena Cavadini, Loredana Cleris, Sabrina Dallavalle, Loana Musso, Maria G. Daidone   +6 more
doaj   +1 more source

Genetic variants in Hippo pathway genes are associated with house dust mite‐induced allergic rhinitis in a Chinese population

Clinical and Translational Allergy, 2021
Background House dust mite (HDM)‐induced allergic rhinitis (AR) is a highly prevalent disease with bothersome symptoms. Genetic variants of the Hippo pathway genes play a critical role in the respiratory disease.
Min Chen, Rui Zheng, Fei Li, Jun‐Yi Xin, Si‐Lu Chen, Xin‐Jie Zhu, Xiang Gu, Meng‐Di Dai, Yi‐Fan Yang, Hai‐Yan Chu, Zheng‐Dong Zhang, Mei‐Ping Lu, Lei Cheng   +12 more
doaj   +1 more source

Regional Variations in Pesticide Residue Detection Rates and Concentrations in Saudi Arabian Crops

Toxics, 2023
There is a scarcity of evidence on the levels of pesticide residues among common crops grown in the different regions of the Kingdom of Saudi Arabia (KSA). The present study aims to fill this gap.
Majed S. Alokail, Sherif H. Abd-Alrahman, Abdullah M. Alnaami, Syed D. Hussain, Osama E. Amer, Manal E. A. Elhalwagy, Nasser M. Al-Daghri   +6 more
doaj   +1 more source

Phospholipids profiling and outcome of peritoneal dialysis patients

, 2014
Objectives: To investigate phospholipids (PLs) biomarkers in predicting outcome of patients undergoing peritoneal dialysis (PD). Materials and methods: Twenty PD patients were followed using baseline plasma PLs with an improved online two-dimensional ...
Li, Min, Tang, Wen, Lu, Xin-Hong, Wang, Tao, Liu, Hu-Wei   +4 more
core   +1 more source

Screening and testing for endocrine disruption in fish-biomarkers as "signposts," not "traffic lights," in risk assessment [PDF]

, 2006
Biomarkers are currently best used as mechanistic "signposts" rather than as "traffic lights" in the environmental risk assessment of endocrine-disrupting chemicals (EDCs).
Helmut Segner, Charles R. Tyler, Ankley, GT, Segner, Helmut, Hutchinson, Thomas H, Tyler, Charles R, Thomas H. Hutchinson, Gerald T. Ankley, Hutchinson, TH, Ankley, Gerald T, Segner, H, Tyler, CR   +11 more
core   +1 more source

Short-term effects of ambient air pollution and childhood lower respiratory diseases

Scientific Reports, 2017
The association between air pollution and childhood respiratory disease is inconsistent. In the present study, we investigated a short-term effect of ambient air pollutants and daily childhood lower respiratory diseases (CLRD).
Liyang Zhu, Xuhua Ge, Yaoyao Chen, Xinying Zeng, Wang Pan, Xu Zhang, Shuai Ben, Qi Yuan, Junyi Xin, Wei Shao, Yuqiu Ge, Dongmei Wu, Zhong Han, Zhengdong Zhang, Haiyan Chu, Meilin Wang   +15 more
doaj   +1 more source

Biomarkers of environmental tobacco smoke exposure. [PDF]

, 1999
Biomarkers are desirable for quantitating human exposure to environmental tobacco smoke (ETS) and for predicting potential health risks for exposed individuals. A number of biomarkers of ETS have been proposed.
Benowitz, NL, N L Benowitz
core   +1 more source

Exosome–transmitted long non-coding RNA PTENP1 suppresses bladder cancer progression

Molecular Cancer, 2018
Background Extracellular communication within the tumor microenvironment plays a critical role in tumor progression. Although exosomes can package into long non-coding RNAs (lncRNAs) to mediate extracellular communication, the role of exosomal lncRNA ...
Rui Zheng, Mulong Du, Xiaowei Wang, Weidong Xu, Jiayuan Liang, Wenying Wang, Qiang Lv, Chao Qin, Haiyan Chu, Meilin Wang, Lin Yuan, Jing Qian, Zhengdong Zhang   +12 more
doaj   +1 more source

Association between circulating vitamin E and ten common cancers: evidence from large-scale Mendelian randomization analysis and a longitudinal cohort study

BMC Medicine, 2022
Background The association between vitamin E and cancer risk has been widely investigated by observational studies, but the findings remain inconclusive.
Junyi Xin, Xia Jiang, Shuai Ben, Qianyu Yuan, Li Su, Zhengdong Zhang, David C. Christiani, Mulong Du, Meilin Wang   +8 more
doaj   +1 more source