Results 11 to 20 of about 5,373,729 (260)

Determining cut-points for Alzheimer's disease biomarkers: statistical issues, methods and challenges. [PDF]

, 2012
New proposed criteria for the clinical diagnosis of Alzheimer's disease increasingly incorporate biomarkers, most of which are normally measured on a continuous scale. Operationalizing such criteria thus requires continuous biomarkers to be dichotomized,
Skillbäck, Tobias,, Blennow, Kaj,, Bartlett, Jonathan W, Zetterberg, Henrik,, Blennow, Kaj, Zetterberg, Henrik, Frost, Chris, Mattsson, Niklas, Skillbäck, Tobias, Schott, Jonathan M, Mattsson, Niklas,   +10 more
core   +1 more source

A prospective study of the associations among fine particulate matter, genetic variants, and the risk of colorectal cancer

Environment International, 2021
Background: Fine particulate matter (PM2.5) is suspected to increase the risk of colorectal cancer, but the mechanism remains unknown. We aimed to investigate the association between PM2.5 exposure, genetic variants and colorectal cancer risk in the ...
Haiyan Chu, Junyi Xin, Qi Yuan, Yanling Wu, Mulong Du, Rui Zheng, Hanting Liu, Shaowei Wu, Zhengdong Zhang, Meilin Wang   +9 more
doaj   +1 more source

LncRNA BCLET variant confers bladder cancer susceptibility through alternative splicing of MSANTD2 exon 1

Cancer Medicine, 2023
Background Alternative splicing (AS)‐related single nucleotide polymorphisms (SNPs) are associated with risk of cancers, but the potential mechanism has not been fully elucidated.
Hanting Liu, Xi Wang, Zheng Guo, Guanting Sun, Qiang Lv, Chao Qin, Lin Yuan, Yunyan Wang, Mulong Du, Meilin Wang, Zhengdong Zhang, Haiyan Chu   +11 more
doaj   +1 more source

Genome-wide DNA methylation analysis reveals loci that distinguish different types of adipose tissue in obese individuals

Clinical Epigenetics, 2017
Background Epigenetic mechanisms provide an interface between environmental factors and the genome and are known to play a role in complex diseases such as obesity.
Donia Macartney-Coxson, Miles C. Benton, Ray Blick, Richard S. Stubbs, Ronald D. Hagan, Michael A. Langston   +5 more
doaj   +1 more source

Proteomic candidate biomarkers of drug-induced nephrotoxicity in the rat [PDF]

, 2012
Improved biomarkers of acute nephrotoxicity are coveted by the drug development industry, regulatory agencies, and clinicians. In an effort to identify such biomarkers, urinary peptide profiles of rats treated with two different nephrotoxins were ...
Hanig, J., Mischak, H., Harald Mischak (103627), Rouse Rodney, Mullen, W., Metzger, J., William Mullen (103621), Rodney Rouse, William Mullen, Jochen Metzger, Jochen Metzger (171762), Hanig Joseph, Siwy, J., Joseph Hanig, Justyna Siwy (103595), Mullen William, Harald Mischak, Rouse, R., Justyna Siwy, Rodney Rouse (171753), Metzger Jochen, Joseph Hanig (82484), Siwy Justyna, Mischak Harald   +23 more
core   +2 more sources

LncRNA MT1JP functions as a ceRNA in regulating FBXW7 through competitively binding to miR-92a-3p in gastric cancer

Molecular Cancer, 2018
Background Emerging evidence has shown that dysregulation function of long non-coding RNAs (lncRNAs) implicated in gastric cancer (GC). However, the role of the differentially expressed lncRNAs in GC has not fully explained.
Gang Zhang, Shuwei Li, Jiafei Lu, Yuqiu Ge, Qiaoyan Wang, Gaoxiang Ma, Qinghong Zhao, Dongdong Wu, Weida Gong, Mulong Du, Haiyan Chu, Meilin Wang, Aihua Zhang, Zhengdong Zhang   +13 more
doaj   +1 more source

Aging Injury Impairs Structural Properties and Cell Signaling in Human Red Blood Cells; Açaì Berry Is a Keystone

Antioxidants, 2023
Red blood cell (RBC) deformability is the ability of cells to modulate their shape to ensure transit through narrow capillaries of the microcirculation.
Sara Spinelli, Elisabetta Straface, Lucrezia Gambardella, Daniele Caruso, Giuseppe Falliti, Alessia Remigante, Angela Marino, Rossana Morabito   +7 more
doaj   +1 more source

STrengthening the Reporting of OBservational studies in Epidemiology--Molecular Epidemiology STROBE-ME: an extension of the STROBE statement. [PDF]

, 2011
Advances in laboratory techniques have led to a rapidly increasing use of biomarkers in epidemiological studies. Biomarkers of internal dose, early biological change susceptibility and clinical outcomes are used as proxies for investigating the ...
David H. Phillips, Schoket, B, Peter B Farmer, Dep IRAS, G. Matullo (7601792), Vermeulen Roel, Giuseppe Matullo, Valentina Gallo, Kirsch-Volders, Micheline, B. Schoket (7601798), Porta Miquel, Kirsch-Volders, M, R. Vermeulen, Miquel Porta, Wild Christopher, Egger, M, Phillips, David, Gallo Valentina, Egger, M., Phillips, D.H., Phillips, DH, Vineis, P., Farmer, P.B., Porta, M, John P.A. Ioannidis, John P. A. Ioannidis, C. Wild, McCormack Valerie, Porta, Miquel, Porta, M., U. Stromberg (7601801), Lund University., M. Egger, Roel Vermeulen, Stromberg, U., Ioannidis, John P. A., Matullo, Giuseppe, Farmer, Peter B, P. Vineis (7601795), David H Phillips, Christopher Wild, McCormack, Valerie, Schoket Bernadette, B. Schoket, Farmer, PB, John P A Ioannidis, G. Matullo, Stromberg, U, Ioannidis, JP, Wild, C., Farmer, Peter B., Ulf Stromberg, Valerie McCormack, Matullo Giuseppe, V. Gallo (7601771), Vineis, Paolo, Loannidis, John P. A., D. H. Phillips (2298805), Gallo, Valentina, V. Mccormack (7601777), Wild, Christopher, V. Gallo, U. Stromberg, STROBE Statement, J. P. A. Ioannidis (7601786), M. Egger (7601774), P. B. Farmer, Matthias Egger, C. Wild (7601780), Schoket, B., V. McCormack, Strömberg, Ulf,, Gallo, V., P. Vineis, Gallo, V, Phillips, David H., Peter B. Farmer, Wild, C, Kirsch-Volders, M., R. Vermeulen (3788842), Phillips, David H, ?, ?, Stromberg, Ulf, McCormack, V., Phillips David H., M. Porta (7601804), Farmer Peter B., Ioannidis John P. A., M. Kirsch-Volders, Bernadette Schoket, Egger, Matthias, Egger Matthias, Ioannidis, John P A, McCormack, V, Vermeulen, Roel, Risk Assessment of Toxic and Immunomodulatory Agents, D. H. Phillips, Ioannidis, J.P., M. Porta, Matullo, G, Stromberg Ulf, Vineis Paolo, Vermeulen, R., Ioannidis, John PA, J. P. A. Ioannidis, M. Kirsch-Volders (7601789), Schoket, Bernadette, Matullo, G., P. B. Farmer (7601783), Vineis, P, STROBE Statement,, Kirsch-Volders Micheline, Micheline Kirsch-Volders, Porta, Miguel, Paolo Vineis, Vermeulen, R   +115 more
core   +12 more sources

Scientific Profiles in the field of Biomarkers (2000-2010) [PDF]

, 2013
Biological marker is a term used in many scientific fields and was introduced as a measurable element or a clinical indicator in the abnormal biological processes, pathological condition, or pharmacological intervention.
Biglu, Mohammad-Hossein, Biglu, Sahar, Mehdi , Saberian-Brojeni, Giti, Shahmohammadi   +3 more
core   +1 more source

Exosomal circLPAR1 functions in colorectal cancer diagnosis and tumorigenesis through suppressing BRD4 via METTL3–eIF3h interaction

Molecular Cancer, 2022
Background Exosomes have emerged as vital biomarkers of multiple cancers and contain abundant circular RNAs (circRNAs). However, the potential for exosomal circRNAs to be used in diagnostics and their molecular mechanism of action in colorectal cancer ...
Rui Zheng, Ke Zhang, Shanyue Tan, Fang Gao, Yajie Zhang, Wenxia Xu, Huabin Wang, Dongying Gu, Lingjun Zhu, Shuwei Li, Haiyan Chu, Zhengdong Zhang, Lingxiang Liu, Mulong Du, Meilin Wang   +14 more
doaj   +1 more source