Results 91 to 100 of about 1,505,378 (311)

In utero tobacco smoke exposure, DNA methylation, and asthma in Latino children. [PDF]

, 2019
BackgroundMaternal smoking during pregnancy is a risk factor for chronic disease later in life and has been associated with variability of DNA methylation at specific cytosine-phosphate-guanine (CpG) loci.
Barker, Beach, Beamer, Best, Cardenas, Chhabra, Cunningham, DiFranza, Galanter, Gibbs, Gilliland, Gilliland, Gilliland, Hanieh, Harb, Hu, Jaakkola, Jauniaux, Joubert, Joubert, Küpers, Lara, Morales, Oh, Perreira, Pickett, Rahmani, Reese, Reese, Rehan, Richiardi, Richmond, Richmond, Sharma, Shorey-Kendrick, Stick, Stocks, Tong, Upton, van der Laan, Vanderweele, VanderWeele, Waterland, Wongtrakool, Wu, Zeilinger, Zhang, Zhong   +47 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Amazonian mammal monitoring using aquatic environmental DNA

Molecular Ecology Resources, 2020
AbstractEnvironmental DNA (eDNA) metabarcoding has emerged as one of the most efficient methods to assess aquatic species presence. While the method can in theory be used to investigate nonaquatic fauna, its development for inventorying semi‐aquatic and terrestrial fauna is still at an early stage.
Coutant, Opale, Richard‐hansen, Cécile, de Thoisy, Benoit, Decotte, Jean‐baptiste, Valentini, Alice, Dejean, Tony, Vigouroux, Régis, Murienne, Jérôme, Brosse, Sébastien   +8 more
openaire   +4 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

A qPCR Assay for the Threatened Pilbara Olive Python (Liasis olivaceus barroni)

Environmental DNA
The Pilbara olive python (Liasis olivaceus barroni) is endemic to the Pilbara region of Western Australia and listed as threatened. Despite being a priority conservation target, they are difficult to monitor as their cryptic nature complicates ...
Kathryn L. Dawkins, Benjamin L. Heyward, Mahsa Mousavi‐Derazmahalleh, Nicole E. White, Morten E. Allentoft   +4 more
doaj   +1 more source

Comparative analysis of diet composition and gut parasite diversity in bar-headed geese and ruddy shelducks using environmental dna metabarcoding [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi
We comprehensively analyzed the dietary preferences and intestinal parasite diversity of two waterbirds, the Ruddy shelduck (Tadorna ferruginea) and the Bar-headed goose (Anser indicus), using environmental DNA metabarcoding with the 18S rDNA V9 (for ...
Yonggang DONG, Yuliang HOU, Xuelian WANG, Fang YANG, Zhuoma LANCUO, Wen WANG   +5 more
doaj   +1 more source

Native Plasmid-Encoded Mercury Resistance Genes Are Functional and Demonstrate Natural Transformation in Environmental Bacterial Isolates. [PDF]

, 2019
Plasmid-mediated horizontal gene transfer (HGT) is a major driver of genetic diversity in bacteria. We experimentally validated the function of a putative mercury resistance operon present on an abundant 8-kbp native plasmid found in groundwater samples ...
Carlson, Hans K, Deutschbauer, Adam M, Kothari, Ankita, Mukhopadhyay, Aindrila, Soneja, Drishti, Tang, Albert   +5 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Evaluation of Extraction Methods for the Recovery of Vertebrate DNA From Spider Webs

Environmental DNA
Spider webs have recently been recognized as an excellent source of vertebrate eDNA. Here we compare four sample preparation methods and three commercially available DNA extraction kits to optimize vertebrate eDNA recovery. We assessed DNA yield, purity,
Joshua P. Newton, Morten E. Allentoft, Philip W. Bateman, Matthew A. Campbell, Mahsa Mousavi‐Derazmahalleh, Paul Nevill   +5 more
doaj   +1 more source

Genomic resources for the monitoring and management of Tometes trilobatus, Hoplias aimara and Myloplus rhomboidalis, three exploited freshwater fish species in French Guiana

Knowledge and Management of Aquatic Ecosystems
The Neotropical region, hosts a quarter of all freshwater fish species, while providing important food resources for local human populations. The management of neotropical freshwater ecosystems is thus of primary importance for both biodiversity ...
Condachou Céline, Cuenot Yves, Pigeyre Laetitia, Covain Raphael, Vigouroux Régis, Brosse Sébastien, Murienne Jérôme   +6 more
doaj   +1 more source