Results 101 to 110 of about 4,747,291 (301)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
of the Carcinogen Identification Committee of the OEHHA Science Advisory [PDF]
65, California Health and Safety Code 25249.5 et seq.) requires that the Governor cause to be published a list of those chemicals “known to the state” to cause cancer or reproductive toxicity.
Health Hazard Assessment +1 more
core
Mapping Child Well-Being in Duval County, FL [PDF]
, 2011 Analyzes the distribution of neighborhood, education, and health/environmental opportunity; impact on health and education outcomes; demographics of those in Children's Commission programs; and marginalized neighborhoods' conditions.
Mikyung Baek +2 more
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Journal of Marine Science and EngineeringThis study investigates the effects on hard-bottom macro-zoobenthic communities of converting a mariculture plant into an Integrated Multi-Trophic Aquaculture (IMTA) system. This study was conducted from 2018 to 2021 in the semi-enclosed Mar Grande basin
Roberta Trani +7 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Long-Term Effect of Air Pollution on COPD Exacerbations: AIREPOC Cohort in Bogotá, Colombia
Atmosphere(1) Background: Evidence on the association between air pollution and the risk of exacerbations of chronic obstructive pulmonary disease (COPD) is scarce and inconsistent.
Astrid Berena Herrera López +8 more
doaj +1 more source
Environmental Health Risk Analysis Exposure to Nitrogen Dioxide (No2) and Sulfur Dioxide (So2) on Street Vendor in Ampera Terminal Palembang 2015 [PDF]
, 2015 Background: Terminal is a location that generates air pollution as a result of transport activity performed. The use of motorized transport will produce a wide range of gases including NO2 and SO2.
Arista, G. (Gita) +2 more
core